Clinical trials
Melanoma (Skin) clinical trials
Below are recruiting melanoma (skin) clinical trials, each written for real people, not researchers. We’re tracking 101 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07138222Recruiting
Immune therapy and fertility in women and men with melanoma
This study looks at how immune checkpoint inhibitors (a type of immunotherapy) affect fertility and hormone health in premenopausal women and men with melanoma. It aims to understand and manage these side effects while you receive treatment.
Sydney, New South WalesAges 18–60 - NCT07349303RecruitingPhase 2
Pembrolizumab Before Surgery for Stage IIb/c Melanoma
This trial tests whether giving pembrolizumab (Keytruda) before surgery helps people with a certain type of advanced melanoma (stage IIb/c). The goal is to see if this treatment can improve outcomes before the tumor is removed.
GothenburgAges 18 years+ - NCT07404605Recruiting
Electrochemotherapy for skin melanoma study
This study tests if electrochemotherapy can change the environment around melanoma tumors. It may help patients with melanoma that has spread to the skin or just under the skin.
LjubljanaAges 18 years+ - NCT07448831RecruitingPhase 2
Pembrolizumab before surgery for high-risk melanoma
This trial tests whether giving the immunotherapy drug pembrolizumab before surgery can help people with high-risk melanoma. It is for patients whose melanoma has not spread and who have not had prior treatment for melanoma.
Jette, Brussels CapitalAges 18 years+ - NCT07327489Recruiting
Live tumor biopsy study to predict immunotherapy response
This trial studies how well immunotherapy might work by analyzing fresh tumor biopsies. It may help predict which treatments are best for your cancer.
Fort Smith, ArkansasAges 18 years+ - NCT07584291Recruiting
Blood Tests and Tissue Study for Melanoma
This research study analyzes blood and tissue samples from melanoma patients to identify biological markers that could help doctors better understand and treat the disease. Researchers will examine archived tissue samples and blood work to develop improved diagnostic tools.
Xi'an, ShaanxiAges 18–80 - NCT07586891Recruiting
Low-Branched-Chain Amino Acid Diet With Immunotherapy for Stage III Melanoma
This trial tests whether a special diet low in certain amino acids (building blocks of protein), combined with an immune-boosting antibody drug, can safely shrink stage III melanoma that has spread to lymph nodes. The goal is to see if this combination works better than standard treatment.
Xi'anAges 18–75 - NCT07586904RecruitingEarly Phase 1
New Immunotherapy Combination for Advanced Melanoma
This trial tests a combination of two drugs (cadonilimab and interferon) given before surgery to treat advanced melanoma that has spread to nearby lymph nodes or one distant site. The goal is to shrink tumors and improve chances of successful surgery and long-term survival.
Xi'anAges 18–75 - NCT07201376Recruiting
Testing a skin imaging device for non-melanoma skin cancer
This study tests a device that uses a special light to image skin lesions after applying an FDA-approved cream. It aims to see if the device can help doctors see benign skin growths more clearly before they are removed.
Lebanon, New HampshireAges 18 years+ - NCT06384053Recruiting
Heat plus radiation for skin cancer in older adults
This trial tests whether adding heat therapy (hyperthermia) to radiation therapy works well for older adults with larger non-melanoma skin cancers. It may help shrink tumors without needing surgery.
Aarau, Canton of AargauAges 65 years+ - NCT05779423RecruitingPhase 2
Freezing tumor plus two immunotherapies for advanced melanoma
This trial tests whether combining a local treatment that freezes a tumor (cryoablation) with two immune “checkpoint” medicines (ipilimumab and nivolumab) can better control unresectable melanoma. It may help when melanoma has grown after prior immune therapy.
Boston, MassachusettsAges 18 years+ - NCT06400550Recruiting
Melanoma metabolism and spread risk study
This study looks at how the body's metabolism might affect the spread of melanoma. Researchers want to see if certain metabolic traits in people with melanoma are linked to a higher risk of the cancer spreading.
Dallas, TexasAges 18 years+ - NCT06545682RecruitingPhase 1
Study of alpelisib and pembrolizumab for advanced breast cancer or melanoma
This trial tests a combination of two drugs, alpelisib and pembrolizumab, for people with advanced triple-negative breast cancer or melanoma that has spread. The goal is to see if the combination can help shrink tumors, including those that have spread to the brain.
Houston, TexasAges 18 years+ - NCT07031830Recruiting
Physical activity program for advanced melanoma patients
This trial tests whether an adapted physical activity program can help patients with advanced melanoma who are receiving immunotherapy or targeted therapy. It aims to support overall well-being during treatment.
RouenAges 18 years+ - NCT06060613RecruitingPhase 1/Phase 2
OBX-115 cell therapy for advanced melanoma or lung cancer
This trial tests an experimental cell therapy called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has not responded to standard treatments. The therapy uses your own immune cells to fight the cancer. The study aims to see if it is safe and effective.
Los Angeles, CaliforniaAges 18 years+ - NCT07718243RecruitingPhase 1/Phase 2
Combining two immunotherapies for solid tumors, melanoma, and lung cancer
This trial tests a new drug (bexmarilimab) plus nivolumab (an approved immunotherapy) for people with advanced solid tumors, melanoma, or non-small cell lung cancer (NSCLC) that has stopped responding to standard treatments.
ManchesterAges 18 years+ - NCT05704647RecruitingPhase 2
Nivolumab plus relatlimab for melanoma in the brain
This Phase 2 study tests whether nivolumab plus relatlimab can shrink or control melanoma that has spread to the brain. It may help by boosting the immune system to attack the cancer, including melanoma in brain areas that can’t be treated with prior focused radiation.
Houston, TexasAges 18 years+ - NCT07530887RecruitingPhase 3
Melanoma Re-excision Study: Testing Observation Without Surgery
This study tests whether patients with moderate-thickness skin melanoma need additional surgery after their initial tumor removal, or if careful monitoring alone is enough. The goal is to avoid unnecessary surgery while keeping patients safe.
's-HertogenboschAges Any age - NCT07422779Recruiting
Immunotherapy for advanced melanoma study
This study tests how well immunotherapy drugs like pembrolizumab and nivolumab work for people with advanced melanoma that has spread. It aims to find markers that predict treatment response.
LjubljanaAges 18 years+ - NCT06223659RecruitingPhase 2
EMLA cream for pain during lymphoscintigraphy for skin cancer
This trial tests whether EMLA cream can reduce pain from injections needed to map lymph nodes for certain skin cancers. If you are scheduled for lymphoscintigraphy and sentinel lymph node biopsy, you may be eligible.
Columbus, OhioAges 18–99 - NCT03315468Recruiting
Melanoma patient study in France database
This study collects information from people with melanoma (skin cancer), at any stage. It may help researchers better understand melanoma and improve future care.
NantesAges 18 years+ - NCT07556380Recruiting
Mobile app to help melanoma survivors stay safe in the sun
This study helps people who've had melanoma learn healthy habits around sun exposure and outdoor activity. You'll use a smartphone app, wear special tracking devices, and share information about your time outside to help researchers develop better ways to protect skin cancer survivors.
Chicago, IllinoisAges 18 years+ - NCT07680452Recruiting
High-fiber diet and short-term fasting for melanoma patients on immunotherapy
This trial tests if a high-fiber diet and occasional short-term fasting can help melanoma patients respond better to immunotherapy. It aims to improve treatment outcomes by changing gut health.
Berlin, State of BerlinAges 18 years+ - NCT05373823Recruiting
Online skin check coaching for melanoma survivors
This study tests an online program to help melanoma survivors do full-body skin self-checks regularly. It may help you catch new or changing skin areas earlier by improving how often and how thoroughly you check.
New Brunswick, New JerseyAges 18 years+
Hear when a new Melanoma (Skin) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for melanoma (skin)?
- Yes. Clin2 currently lists 101 recruiting melanoma (skin) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma (skin) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma (skin) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.