Clinical trials
Melanoma (Skin) clinical trials
Below are recruiting melanoma (skin) clinical trials, each written for real people, not researchers. We’re tracking 104 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06298734Recruiting
Exercise and diet study for melanoma patients on immunotherapy
This study tests whether adding high-intensity exercise and a high-fiber diet can improve how well immunotherapy works for people with melanoma. It might help you if you are already on immunotherapy and are not currently very active or eating a lot of fiber.
Boston, MassachusettsAges 18 years+ - NCT07686835RecruitingPhase 2
High-fiber diet to help immunotherapy work better in advanced melanoma
This trial tests if adding extra dietary fiber before and during immunotherapy can change gut bacteria to make the treatment more effective. It is for people with advanced melanoma who are about to start their first immunotherapy.
Nijmegen, GelderlandAges 18 years+ - NCT05655312RecruitingPhase 1/Phase 2
Targeted radiation melanoma treatment with or without nivolumab
This early-stage study tests whether a targeted radioactive drug can shrink advanced melanoma, either alone or along with nivolumab (an immune-activating medicine). You may be eligible if your melanoma shows a specific target on scan imaging and has progressed despite prior melanoma treatments.
Orange, CaliforniaAges 18–90 - NCT06784778Recruiting
Testing a blood test to predict immunotherapy response
This study is testing a new blood test called IOpener®-Melanoma to see if it can predict which patients with advanced melanoma will respond well to immunotherapy. The goal is to better match treatments to people who will benefit most.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06771544RecruitingPhase 2
Cyclophosphamide and pembrolizumab for advanced melanoma
This trial tests a combination of daily low-dose cyclophosphamide (a chemotherapy pill) and pembrolizumab (an immunotherapy) in people with advanced melanoma that has stopped responding to prior immunotherapy. The goal is to see if this combination can help shrink tumors or slow the disease.
Orange, CaliforniaAges 18 years+ - NCT06643286Recruiting
Melanoma survivorship care plan app study
This trial tests a mobile app that provides a personalized survivorship care plan for people recently diagnosed with early-stage melanoma. It aims to help patients manage their follow-up care and improve quality of life.
Dordrecht, South HollandAges 18 years+ - NCT07266142Recruiting
Skin cancer research biobank study
This study collects data and samples from people with skin cancer and healthy volunteers to help research. It may be a way to contribute to future treatments.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06624644RecruitingPhase 2/Phase 3
LNS8801 with or without pembrolizumab for advanced melanoma
This trial tests a new drug called LNS8801, alone or with pembrolizumab, for people with advanced melanoma that has stopped responding to prior treatments, especially anti-PD-1 therapy.
Newport Beach, CaliforniaAges 18 years+ - NCT06605443Recruiting
Precision medicine for large/giant congenital nevus and melanoma
This trial uses a precision medicine approach for people with melanoma. It studies how volatile organic compounds (substances your body releases) might help guide treatment for stage II, III, or IV melanoma.
BarcelonaAges 18 years+ - NCT07347392Enrolling by invitation
Radiation therapy for head and neck skin cancer study
This study looks at the role of radiation therapy in treating non-melanoma skin cancers (like basal cell carcinoma or squamous cell carcinoma) on the head and neck. It may help doctors better understand how well this treatment works and who benefits most.
Aarhus NAges 18 years+ - NCT05940311Recruiting
Blood test for melanoma with BRAF V600E mutation
This trial studies a very sensitive blood test to detect melanoma-related genetic changes in people with BRAF V600E. It may help track the disease more closely and guide care in advanced or high-risk situations.
RomeAges 18 years+ - NCT06965231RecruitingPhase 2
Perioperative Toripalimab and Endostatin for Stage II Melanoma
This trial tests a combination of two drugs, toripalimab (an immunotherapy) and endostatin (which targets blood vessels), given before and after surgery for stage II melanoma. The goal is to see if this combination helps prevent the cancer from coming back.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07251335Recruiting
Melanoma and work sun exposure study
This study looks at whether men and women who get melanoma (a type of skin cancer) have had more sun exposure at work compared to those who don't have melanoma. It aims to help find and prevent work-related skin cancers.
Modena, MoAges 18 years+ - NCT05620290RecruitingPhase 1
MR-guided ultrasound plus radiation to help skin cancer respond
This Phase 1 study tests a new way to make radiation work better using MRI-guided focused ultrasound. It focuses on improving treatment for malignant melanoma and other skin cancers, while checking safety and how patients experience treatment.
Toronto, OntarioAges 18 years+ - NCT04844528RecruitingPhase 2
Nicotinamide for CLL patients with recent skin cancer history
This Phase 2 trial tests whether nicotinamide (a form of vitamin B3) can help people with chronic lymphocytic leukemia (CLL) who have had non-melanoma skin cancers in the past 5 years. The study looks at how well new skin cancers can be prevented or reduced.
Salt Lake City, UtahAges 18 years+ - NCT06608420Recruiting
Precision Medicine Study for Melanoma
This study looks at using precision medicine to better understand and treat melanoma. Patients with a confirmed melanoma diagnosis can join, helping doctors learn more about the disease and improve care.
Barcelona, CataloniaAges Any age - NCT06605417Recruiting
Understanding Birthmark to Melanoma Changes
This study looks at how certain birthmarks (nevi) change over time and might turn into melanoma. By studying tissue samples, researchers hope to better understand this process.
MarseilleAges Any age - NCT05896839RecruitingPhase 1/Phase 2
Immunotherapy with prednisone and sirolimus for transplant skin cancer
This early-phase study tests whether adding immunotherapy (nivolumab and ipilimumab) to prednisone and sirolimus can control advanced skin cancers in people with kidney transplants. It aims to see how well the treatment works and how safe it is for transplant recipients.
La Jolla, CaliforniaAges 18 years+ - NCT07349940Recruiting
Early skin cancer detection via telemedicine in primary care
This study tests if a telemedicine tool can help find skin tumors early. It may be a good fit if you have a suspicious spot and light skin that burns easily.
BrnoAges 50 years+ - NCT07144306Recruiting
AI-powered skin cancer detection study
This trial tests an artificial intelligence system designed to spot skin cancer early. You may be able to join if you are an adult with a suspicious skin spot and can give permission to participate.
LondonAges 1.5 years+ - NCT07410676RecruitingPhase 1/Phase 2
Donor NK cells with IL-15 and pembrolizumab for advanced solid tumors
This trial tests a new type of cell therapy (natural killer cells) made from a donor, combined with low-dose IL-15 (a protein that helps these cells work) and sometimes with pembrolizumab (Keytruda), for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges Any age - NCT05307289Recruiting
Melanoma trial studying why immunotherapy stops working
This study looks at how melanoma cells “use energy” (tumor metabolism) to understand why immunotherapy can become less effective over time. If you are starting immunotherapy for advanced skin melanoma, the results may help improve future treatments for resistance.
Nice, Alpes-maritimesAges 18 years+ - NCT06439979Recruiting
Rural sun protection study for families and coaches
This study tests ways to help families and kids in rural Utah and West Virginia protect their skin from the sun during sports. It looks at sun safety habits and may include surveys or interviews for parents, coaches, and kids age 3 and older.
Salt Lake City, UtahAges 3–7 - NCT06774989Recruiting
Drug level monitoring in metastatic melanoma treatment
This trial checks how much of two drugs, encorafenib and binimetinib, remain in your blood while treating advanced melanoma that cannot be removed by surgery. The goal is to learn if drug levels affect how well the treatment works.
Boulogne-BillancourtAges 18 years+
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Melanoma (Skin) trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for melanoma (skin)?
- Yes. Clin2 currently lists 104 recruiting melanoma (skin) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma (skin) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma (skin) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.