Clinical trials · Pittsburgh, PA
Melanoma clinical trials in Pittsburgh
We’re tracking 36 recruiting melanoma studies with a site in or near Pittsburgh — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Pittsburgh
- NCT07015190RecruitingPhase 3
Darovasertib before surgery for eye melanoma
This trial tests a drug called darovasertib given before standard surgery for primary uveal melanoma (a type of eye cancer that hasn't spread). The goal is to see if the drug can shrink the tumor and improve outcomes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05549297RecruitingPhase 3
Tebentafusp plus choice of treatment for advanced melanoma
This Phase 3 study compares tebentafusp treatment against the doctor’s choice of standard options in people with previously treated advanced melanoma. It aims to see which approach works better for controlling the cancer and improving outcomes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05655312RecruitingPhase 1/Phase 2
Targeted radiation melanoma treatment with or without nivolumab
This early-stage study tests whether a targeted radioactive drug can shrink advanced melanoma, either alone or along with nivolumab (an immune-activating medicine). You may be eligible if your melanoma shows a specific target on scan imaging and has progressed despite prior melanoma treatments.
Pittsburgh, PennsylvaniaAges 18–90 - NCT06444815RecruitingPhase 1
Study of VET3-TGI for advanced solid tumors
This trial tests an experimental treatment called VET3-TGI, which is injected directly into tumors. It is for people with advanced solid tumors who have already tried other treatments and are looking for new options.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05727904RecruitingPhase 3
New immunotherapy for advanced melanoma, with or without lifileucel
This trial studies whether adding lifileucel (a patient-specific immune-cell treatment) to pembrolizumab works better than pembrolizumab alone. It’s for people with untreated advanced melanoma that cannot be removed by surgery.
Pittsburgh, PennsylvaniaAges 18–70 - NCT05877430RecruitingPhase 1/Phase 2
Testing an anti-cancer drug plus pembrolizumab for advanced cancers
This Phase 1/2 study tests the safety and early signs of benefit from CJRB-101 when combined with pembrolizumab (Keytruda) in people with advanced or metastatic lung, head and neck, or melanoma cancer. It may help some participants, but the main goal is to see how safe the combination is and whether it can control cancer.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06216938RecruitingEarly Phase 1
RP1 virus therapy for advanced melanoma to lower lymph node spread risk
This trial tests a new kind of virus-based treatment (RP1) given directly into melanoma tumors to see if it can reduce the chance of cancer spreading to nearby lymph nodes. It's for people with thicker or more advanced skin melanoma that still has visible tumor or positive margins after biopsy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07068074RecruitingPhase 3
Comparing less invasive surgery to standard care for older adults with early-stage melanoma
This trial compares less invasive procedures with the current standard treatment for early-stage melanoma in adults 75 and older. The goal is to find out if these less invasive options work just as well and help patients recover better.
Pittsburgh, PennsylvaniaAges 75 years+ - NCT05970497RecruitingPhase 1/Phase 2
KB707 trial for advanced solid tumors after other treatments
This early-stage trial tests KB707 in people with locally advanced or metastatic solid tumors that have not responded well to standard treatments. If you qualify, you may receive KB707 to see how well it can shrink tumors or control the disease.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07040280RecruitingPhase 2
Sulforaphane supplement to prevent new skin cancers in people with many atypical moles
This study tests a supplement made from broccoli sprouts (sulforaphane) to see if it can reduce the risk of developing new melanomas in people who have had melanoma before and have several unusual moles. Participants will take the supplement daily for a certain period and be monitored for skin changes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06070012RecruitingPhase 2
Tebentafusp for untreated metastatic uveal melanoma
This trial tests a new drug called tebentafusp for people with uveal melanoma that has spread to other parts of the body and who have not yet received any treatment for the metastatic disease. It requires a specific genetic marker (HLA-A*0201) and focuses on whether the drug can shrink or slow the growth of tumors.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05334069Recruiting
Blood test study for early cancer detection in patients
This study collects blood from people with cancer and people without cancer (or with possible cancer) to test whether new blood tests can detect cancer earlier. Your blood samples help researchers evaluate how well these tests work.
Meadowbrook, PennsylvaniaAges 40–75
Hear when a new Melanoma trial opens near Pittsburgh, PA
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Melanoma trials in other cities
Where these studies are running near Pittsburgh
Institutions with a site for the recruiting melanoma studies listed above.
- UPMC Hillman Cancer Center · 8 studies
- Allegheny Health Network
- Redeemer Health - Holy Redeemer Hospital
- University of Pittsburgh
- UPMC- Hillman Cancer Center
What taking part in a melanoma study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting melanoma studies in Pennsylvania.
Common questions
- Are there melanoma clinical trials near Pittsburgh?
- Yes. We're currently tracking 36 recruiting melanoma studies with a site near Pittsburgh, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a melanoma study near Pittsburgh?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pittsburgh to take part?
- Not necessarily. These studies have a site near Pittsburgh, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New melanoma studies open near Pittsburgh regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.