Clinical trials
Melasma clinical trials
Below are recruiting melasma clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07071363Recruiting
Serum vs hydroquinone for melasma treatment
This trial compares a new cosmetic serum to a standard treatment (4% hydroquinone) for facial melasma over 84 days. It may help if you have mild to moderate melasma and are looking for a gentler alternative.
Port Louis, PhoenixAges 18–65 - NCT07296549Enrolling by invitation
Expert input on melasma treatment choices
This study gathers expert dermatologists to create guidelines for managing melasma, a skin condition that causes dark patches. If you are an experienced dermatologist, your opinion could help shape future care.
CairoAges 25 years+ - NCT07696806Enrolling by invitationPhase 4
Needle-assisted treatment for melasma using common skin medications
This trial tests a microneedling technique combined with three topical medications (metformin, tranexamic acid, and a modified Kligman's formula) to treat melasma, a common skin condition causing dark patches. The goal is to see if this approach safely and effectively reduces melasma in eligible women.
TantaAges 18 years+ - NCT07202156Recruiting
Ultrasound helps deliver melasma treatment
This trial tests a new way to deliver a medicine (tranexamic acid) into melasma patches using ultrasound waves. It aims to see if the ultrasound helps the medicine work better to lighten the dark spots.
Nanjing, JiangsuAges 20–55 - NCT07540702Recruiting
Platelet-Rich Fibrin vs. Tranexamic Acid for Melasma
This trial tests two injectable treatments for melasma (dark patches on the face): platelet-rich fibrin, which uses your own blood cells to promote healing, and tranexamic acid, a medication that may reduce pigmentation. The study will compare which works better for women with mild to moderate melasma.
Cairo, Cairo GovernorateAges 18–50 - NCT07169383Enrolling by invitationPhase 2
Melatonin vs. tranexamic acid for melasma
This study compares two oral treatments—melatonin and tranexamic acid—to see which works better for reducing melasma. Both are pills you take by mouth, and the goal is to find a safe, effective option for people with this skin condition.
Islamabad, Punjab ProvinceAges 18–50 - NCT07769268Recruiting
Cream for treating dark spots on the face
This study tests a cosmetic cream to reduce dark spots on the face, including melasma and sun spots. It aims to see if the product improves the appearance of hyperpigmentation.
Osasco, São PauloAges 30–60 - NCT05942248Recruiting
Computer image grading for common face skin rashes
This study uses special computer measurements from facial photos to evaluate how acne, rosacea, melasma, or seborrheic dermatitis look. If you have one of these conditions, it may help researchers better track skin changes over time.
Sacramento, CaliforniaAges 18 years+ - NCT06221787Recruiting
Stem cell exosomes for treating facial melasma
This trial tests whether stem cell exosomes, combined with laser or microneedle treatments, can improve melasma (dark patches on the face). It aims to find a better way to lighten these spots.
Fuzhou, FujianAges 18–60 - NCT06454747RecruitingPhase 2
Testing a new gel for moderate to severe melasma
This study tests a new gel (SM-030) for adults with moderate to severe melasma. If you join, you would use the gel on your face for a few months and stop other skin-lightening products, while applying the provided sunscreen every day.
Santa Tecla, La Libertad DepartmentAges 18–65 - NCT06516419Recruiting
Stem cell cream for melasma study
This study tests a cream made from stem cell secretions to see if it can help reduce melasma (dark patches on the face). It may be an option for women who haven't improved with other treatments.
Jakarta Pusat, DKI JakartaAges 30–60 - NCT06845540RecruitingPhase 1/Phase 2
Metformin pills for melasma in Latin American women
This study tests if taking metformin pills can help treat melasma (dark patches on the skin) in Latin American women. It may be a new option for those whose melasma hasn't improved with other treatments.
San Juan, PRAges 21 years+ - NCT06522984Recruiting
Melasma trial: laser vs tranexamic acid injection and pills
This trial compares a laser treatment (fractional erbium YAG) with tranexamic acid given as a shot or pill for melasma. It aims to find which option works better with fewer side effects.
AswānAges 18–40 - NCT07679945Recruiting
Study of facial sunscreen for dark spots
This study tests whether a facial sunscreen can reduce dark spots and pigmentation after 8 weeks of daily use. It may be a good option if you have age spots, melasma, or other dark marks on your face and want a simple, non-invasive treatment.
Campinas, São PauloAges 18 years+
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Common questions
- Are there clinical trials for melasma?
- Yes. Clin2 currently lists 14 recruiting melasma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melasma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melasma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.