Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 310 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07860294Recruiting
Mental imagery and self-regulation for daily activities in Parkinson's
This study tests whether practicing mental imagery (imagining movements) along with self-regulation techniques can help people with Parkinson's disease improve their daily activities. It aims to see if this training makes everyday tasks easier.
Hong KongAges 18 years+ - NCT06900712Recruiting
Single-session program for sexual assault recovery
This trial tests a one-time session designed to help survivors of unwanted sexual contact or assault reduce symptoms of PTSD or depression. It may be a good fit if you live in Ohio and have had these symptoms for at least a month.
Cleveland, OhioAges 18–65 - NCT07222696Recruiting
Health coaching for rheumatoid arthritis to improve mental wellbeing
This study tests if working with a health coach (a trained peer) can help people with rheumatoid arthritis feel better emotionally, especially if they are dealing with depression or anxiety. You would meet with a coach remotely using your phone or computer.
New York, New YorkAges 18 years+ - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+ - NCT07372586Recruiting
Behavioral health support after ICU stay
This study tests a collaborative care model for mental health and recovery after an ICU stay. You might qualify if you visit the MUSC ICU Recovery Clinic within six months of leaving the hospital.
Charleston, South CarolinaAges 18 years+ - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT06601140Recruiting
Testing a smartphone app for tracking depression symptoms
This study tests a smartphone-based emotional monitoring device (EMOCARE) to see if it can accurately measure your mood compared to a standard depression questionnaire. It may help researchers find a simpler way to track depression symptoms.
AgenAges 18 years+ - NCT02443636Recruiting
Join a depression and mental health research registry in Atlantic Canada
This trial is a “registry,” meaning you can share your health information to help researchers study depression and other mental health needs in Atlantic Canada. Being part of the registry may help researchers understand patterns and improve future support and treatments.
Halifax, Nova ScotiaAges Any age - NCT06278532Recruiting
Validating psychosis assessment tools in Lithuanian
This trial tests whether three psychiatric questionnaires work well for people with schizophrenia or related disorders. If you are between 18 and 65 and have one of these diagnoses, joining may help improve care for others like you.
KaunasAges 18–65 - NCT06004414Recruiting
SilverCloud mental health app study for high school students
This study tests a mental health app called SilverCloud in high school students who are feeling anxious or depressed. It aims to see if the app can help improve their mood and wellbeing.
New Brunswick, New JerseyAges 13–22 - NCT06221020Recruiting
Enhanced recovery after pituitary tumor surgery
This study tests a standard care plan to help patients recover faster after surgery to remove a pituitary tumor. It may reduce hospital stay and improve recovery.
Kaohsiung CityAges 20–75 - NCT06797804Recruiting
Horticultural therapy for older adults in long-term care
This study tests if an app-guided gardening program can improve heart health, reduce stress and depression, and boost happiness in older adults living in nursing homes. It aims to see if these sessions can help you feel better overall.
TaipeiAges 65 years+ - NCT06455527Recruiting
Heart-guided brain stimulation for depression
This trial tests whether a non-invasive brain stimulation technique called tDCS, guided by your heart rate, can help improve depression symptoms. If you have mild to moderate depression and are not on medication, you may be eligible.
New York, New YorkAges 18–65 - NCT06430333RecruitingPhase 2
Sleep therapy to prevent depression in pregnancy
This study tests whether a sleep-focused therapy can help prevent depression in pregnant people who have insomnia. If you are 14–31 weeks pregnant and have trouble sleeping, this trial offers a program to improve your sleep and lower your risk of depression.
Novi, MichiganAges 18 years+ - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT07397429Recruiting
Group therapy to reduce anxiety using I-Reconstruction method
This trial tests a group psychotherapy method called 'I-Reconstruction' designed to lower anxiety. You may be eligible if you have moderate to high anxiety, specific trauma-related scores, and are not taking psychiatric medications.
Kyiv, Kyiv OblastAges 18–55 - NCT06910267Recruiting
Depression treatment study for older adults in APS
This study tests if a proven depression treatment can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. If you are feeling depressed and have an open APS case, you may qualify.
Houston, TexasAges 65 years+ - NCT07220486Recruiting
Depression support program for nursing home residents and their helpers
This study tests a program for nursing facility residents who have symptoms of depression and their care partners. It aims to provide emotional and practical support during a short stay.
Boston, MassachusettsAges 18 years+ - NCT04289142RecruitingPhase 4
Testing memory effects of dexmedetomidine during heart surgery
This study looks at how a sleep medicine called dexmedetomidine affects thinking and memory after heart surgery. It compares cognitive outcomes over time to see if this sedation choice changes long-term brain function.
Vancouver, British ColumbiaAges 60 years+ - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT05779761Recruiting
Brief coping exercises for high distress and worry
This study tests brief coping interventions to help people who feel very worried, stuck in negative thoughts, or overly self-critical. You would likely complete short activities using your smartphone and internet while the study checks how your distress changes over time.
New York, New YorkAges 18–65
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Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 310 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.