Clinical trials · California
Mental Health clinical trials in California
We’re tracking 31 recruiting mental health studies with a site in California — including Phase 2 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05846282Recruiting
Student program to reduce mental health strain of resilience
This study is looking at ways to reduce the mental health and health burdens some students carry while trying to be “resilient.” It is for certain high school students in specific grades and backgrounds, to see if the program can help them feel better.
Los Angeles, CaliforniaAges 13 years+ - NCT06712147Recruiting
MHE3: health study for Hispanic residents
This study tests ways to help Hispanic/Latino families overcome health obstacles. You may join if you live in certain San Jose zip codes.
Palo Alto, CaliforniaAges 18–65 - NCT07546604Enrolling by invitation
Game-like app to prevent alcohol and mental health risks in women
This trial tests a smartphone app designed to help women prevent alcohol misuse and mental health problems. You play games in the app to build healthy habits.
Los Angeles, CaliforniaAges 18–69 - NCT07306013Recruiting
SolanoConnex mental health access trial
This trial tests a digital platform to help people with mild to moderate mental health symptoms get connected to care. If you live in Solano County, have a smartphone, and haven't used the platform before, you may be able to join.
Vallejo, CaliforniaAges 18 years+ - NCT06874790Recruiting
Web-based mental health app study for Latina women
This study tests a web-based app to help Latina women in Los Angeles or Orange County who are feeling anxious or depressed. If you are not currently in therapy or on medication, you may be able to join from home using your smartphone or computer.
Los Angeles, CaliforniaAges 18 years+ - NCT06185959Recruiting
New mental health group for Asians and Asian Americans
This study is testing a new mental health support group designed for Asian and Asian American adults. It aims to see if this group helps improve emotional well-being and is a good fit for participants.
Palo Alto, CaliforniaAges 18 years+ - NCT07064915Enrolling by invitationPhase 2
Financial help for parents during pregnancy
This study tests a program that combines medical care with financial support to see if it helps parents feel less stressed, improves pregnancy outcomes, and supports healthy baby development. If you are expecting a baby and get care at certain clinics, you may be able to join.
Harbor City, CaliforniaAges 18 years+ - NCT07219095Recruiting
Dance Mental Health App for Injured Teens
This trial tests a mental health app (SuperBetter) for teens who dance and have a leg injury. It aims to help them cope and stay positive while recovering.
San Diego, CaliforniaAges 13–18 - NCT07339228Enrolling by invitation
Youth soccer and mental health study
This trial combines soccer with behavioral health support to help young people ages 14–21. It tests if joining team sports and group activities improves mental well-being.
Oakland, CaliforniaAges 14–21 - NCT07549178Recruiting
Mobile monitoring and care coordination for serious mental illness
This study tests whether combining extra care coordination with tracking data from your smartphone can help improve mental health care and reduce hospital visits. Researchers will use your smartphone to monitor your wellbeing while a care coordinator helps connect you with the support you need.
West Los Angeles, CaliforniaAges 18 years+ - NCT07387146Recruiting
Community health worker support for mental health
This trial tests whether a community health worker can help reduce stress in adults who speak English or Spanish. If you feel stressed often, you may be able to join.
San Francisco, CaliforniaAges 18–120 - NCT06800833Recruiting
Mango or cookie study for gut, mental, sexual, and skin health
This study is testing whether eating mangoes or low-fat cookies every day for 4 weeks can improve your gut health, and in turn affect your mood, sex life, and skin. If you are generally healthy, not pregnant, and not taking certain medications or supplements, you may be able to join.
San Diego, CaliforniaAges 18–50 - NCT07528261Recruiting
Support Group for Family Caregivers of Stroke Survivors
This study tests whether a support group using acceptance and commitment therapy (a type of counseling that helps people cope with stress) can reduce caregiver burden and distress. You would meet online with other people caring for stroke survivors.
Alameda, CaliforniaAges 40 years+ - NCT06233344RecruitingPhase 2
Mindfulness and psilocybin study for healthy adults
This study tests whether combining mindfulness training with a single dose of psilocybin (a psychedelic found in certain mushrooms) can help healthy adults. It aims to explore how these two approaches together might improve well-being.
Los Angeles, CaliforniaAges 25 years+ - NCT05629013Recruiting
After-action reviews to improve child welfare teams’ care
This study asks child welfare teams and families to review what happened in their team planning meetings, to help improve how services get connected. It may help strengthen the way support services are identified and linked for children in ongoing child welfare cases.
San Diego, CaliforniaAges 6 years+ - NCT04712461Recruiting
Support program to reduce therapist burnout
This trial tests whether adding specific implementation supports can reduce burnout in therapists who provide evidence-based care for children who have experienced trauma. It may help therapists feel more supported while delivering these child trauma treatments.
San Diego, CaliforniaAges 3–99 - NCT07223736Recruiting
AI education for new mothers after birth
This study tests an AI-based education tool for first-time mothers to help with recovery and reduce loneliness after childbirth. You participate from home using your smartphone for 2-6 weeks after delivery.
La Jolla, CaliforniaAges 18 years+ - NCT07717723Recruiting
Support for caregivers of heart disease patients
This study tests a program to help caregivers of people with heart disease manage stress and challenges. It aims to support your mental health while caring for a loved one.
Sacramento, CaliforniaAges 18 years+ - NCT03388606Recruiting
Studying adolescent depression and how to treat it
This study looks closely at how depression shows up in teens and tests approaches to treatment. It may help teens and families better understand depression and get access to structured care as part of research.
Los Angeles, CaliforniaAges 11–25 - NCT05471232Recruiting
Genomic testing for youth mental health crises with IDD
This study looks at genetic (DNA) information to understand mental health crises in youth with intellectual and developmental disabilities. It may help doctors learn why these crises happen and improve how future families are supported.
San Diego, CaliforniaAges 7–17 - NCT05701111Recruiting
School-based treatment for teens with trauma symptoms
This study tests a school-based approach to help teens who have experienced trauma and now have post-trauma symptoms. It also collects emotional and physical (biologic) information to understand how treatment may help.
Palo Alto, CaliforniaAges 11–17 - NCT06486688Recruiting
Virtual program to help teens with substance use risk
This trial tests a virtual program integrated into pediatric check-ups to help teens at risk for alcohol or drug problems. It aims to identify teens who may need extra support and connect them with helpful resources.
Pleasanton, CaliforniaAges 12–17 - NCT06651086Recruiting
Executive functioning help for children in therapy
This study tests a new way to help children with executive functioning challenges (like planning and staying organized) in therapy. It's for kids ages 6-12, with or without autism, who are getting therapy at publicly funded clinics.
San Diego, CaliforniaAges 6–99 - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21
Mental Health trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting mental health studies listed above.
- San Diego State University · 3 studies
- Rady Children's Hospital San Diego · 2 studies
- Stanford University · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
- University of Southern California · 2 studies
- Cultura Y Arte Nativa De Las Americas
- Kaiser Permanente Northern California
- Lomita Family Health Center
What taking part in a mental health study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Mental Health trials in other states
Common questions
- Are there mental health clinical trials in California?
- Yes. We're currently tracking 31 recruiting mental health studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a mental health study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a mental health trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New mental health studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.