Clinical trials
Mood Disorders clinical trials
Below are recruiting mood disorders clinical trials, each written for real people, not researchers. We’re tracking 80 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07771322Recruiting
Online therapy for Asian American adults
This study tests a digital mental health platform designed for Asian Americans. You'll get online therapy sessions, and the goal is to see if the platform helps improve your mental health.
Brooklyn, New YorkAges 18–90 - NCT07052357Enrolling by invitation
Intern health study 2025
This study looks at how medical interns' health changes during their first year of training. You wear a wrist device and answer questions on your phone to help researchers understand stress, sleep, and well-being.
Ann Arbor, MichiganAges 18 years+ - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT06263738Recruiting
Cold and heat therapy for depression
This trial tests if carefully controlled cold or heat exposure can help lower symptoms of depression. It is open to people with or without depression to see how the body responds to changes in temperature.
Edwards, ColoradoAges 18–65 - NCT06275217Recruiting
Mindful yoga for new mothers with low mood
This study tests if a mindful yoga program can help new mothers with symptoms of postpartum depression. If you are feeling down after giving birth and are willing to try gentle yoga and mindfulness, this may be a good option for you.
Hong KongAges 18–60 - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT07087353Recruiting
Remote monitoring for moderate to severe depression
This study tests whether checking in with a mental health team remotely (using your phone) can help people with moderate to severe depression feel better. It’s designed for people who are already getting treatment and want extra support from home.
BesançonAges 18 years+ - NCT07362511Recruiting
Imagery rescripting for depression in primary care
This study tests a type of talk therapy called 'imagery rescripting' for people with depression in primary care. In this approach, you learn to change painful mental images into more helpful ones, which may reduce depressive feelings.
Amsterdam, North HollandAges 18–70 - NCT07676110Recruiting
Music and nature visuals for emotional well-being
This study tests if listening to enhanced music and watching natural visuals can improve your emotional health. You'll use your own headphones and a smartphone or tablet to take part.
Fort Collins, ColoradoAges 13 years+ - NCT07155707Recruiting
Virtual therapy platform for mood and anxiety disorders
This trial tests a virtual therapy platform called Teleo for people with mood or anxiety disorders. It looks at how well patients engage with online therapy and whether it helps their symptoms.
Monterey, CaliforniaAges 5–14 - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT05930886Recruiting
Focus groups with diverse parents about child mental health
This study brings together Black and Hispanic/Latino parents or caregivers to discuss what it’s like to seek help for a child’s attention or emotional challenges. Your feedback helps researchers test whether a future treatment and support program would be practical and acceptable for families.
Portland, OregonAges 18–80 - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT06133231Recruiting
ADHD research with Black and Hispanic families
This study tests if a new approach to ADHD research works well with diverse families. It involves taking supplements and collecting samples at home to see how the body responds.
Portland, OregonAges 6–17 - NCT05414708Recruiting
Art therapy for veterans with PTSD symptoms
This study tests whether art therapy can improve emotional well-being in military members who have significant PTSD symptoms. You would answer questionnaires and likely take part in art-making sessions as part of the treatment being studied.
Bethesda, MarylandAges 18–64 - NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06398496Recruiting
Exercise, gut health, mood in depression
This trial studies whether a 12-week exercise program can improve gut bacteria, mood, and thinking in people with depression. It may help if you are looking for a non-medication way to support your mental health.
Cork, Cork CountyAges 18–59 - NCT06580860Recruiting
Brain health study for young people with early psychosis
This study looks at brain scans and other health information to understand mental health conditions better. You may be able to join if you are a young adult or teen with early signs of mental health changes.
Changsha, HunanAges 13–35 - NCT07246044Recruiting
Brain stimulation for teens with bipolar depression targeting S1
This trial tests a non-invasive brain stimulation technique (HD-tDCS) to see if it can help teens with bipolar disorder who are currently in a depressive episode. It aims to find a new treatment option for adolescent bipolar depression.
Nanjing, JiangsuAges 12–18 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65 - NCT03935646RecruitingPhase 2
Test of Adderall’s short-term effects in college students with ADHD
This study measures how stimulant medication (Adderall) affects college students with ADHD in the short term. It compares people with ADHD to students without ADHD to see what changes you may notice during the study.
Laramie, WyomingAges 18–29 - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT07217925Recruiting
Neurofeedback for people with OCD and PTSD symptoms
This study tests whether a brain training technique called neurofeedback can improve well-being in people who have both OCD and post-traumatic stress symptoms. It is for adults on a therapy waiting list who do not have other serious untreated conditions.
Detroit, MichiganAges 18–90
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Common questions
- Are there clinical trials for mood disorders?
- Yes. Clin2 currently lists 80 recruiting mood disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mood disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mood disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.