Clinical trials
Mood Disorders clinical trials
Below are recruiting mood disorders clinical trials, each written for real people, not researchers. We’re tracking 80 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05985811Recruiting
Ketamine for chronic pain and mood in adults
This trial tests if ketamine injections can improve both pain and mood in adults with chronic pain who also have a mood disorder and trouble sleeping. It may help if you already get regular ketamine treatments.
Surrey, British ColumbiaAges 20–99 - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT06831435Recruiting
Digital therapy for depression study
This study tests if a digital cognitive behavioral therapy program can help treat depression in real-world settings. It is designed for people aged 14 to 60 who have moderate to severe depression symptoms.
Beijing, Beijing MunicipalityAges 14–60 - NCT04817072Recruiting
Studying mood changes in inflammatory arthritis patients on biologics
This study looks at how mood disorders (like depression or anxiety) affect people with chronic inflammatory joint diseases when they use biologic medicines. It may help doctors understand which patients are at higher mood-risk and how to monitor them.
BesançonAges 18–80 - NCT07774481Recruiting
Anxiety skills study for Ohio residents
This study tests an anxiety management program that you can use on your smartphone. It aims to help reduce anxiety symptoms and improve daily functioning.
Columbus, OhioAges 18 years+ - NCT05427123Recruiting
Study for kids and teens with bipolar or cyclothymic disorder
This trial is testing treatments for children and teens (ages 9–19) who have been diagnosed with bipolar disorder or cyclothymic disorder. It also requires regular participation from a caregiver so the team can track symptoms and response over time.
Los Angeles, CaliforniaAges 9–19 - NCT06854367Recruiting
Comparing fast vs. standard brain stimulation for depression in older adults
This study tests if a faster form of brain stimulation (accelerated theta burst stimulation) works as well as the standard version for treating depression in adults 60 and older. It may help those who haven't gotten relief from antidepressant medications.
Toronto, OntarioAges 60 years+ - NCT03859297Recruiting
Testing how rumination changes in depressed teens
This study looks at what changes in “rumination” (repetitive worrying/thinking about negative thoughts) in teens with depression, and how those changes relate to recovery. It’s for ages 14–17 who have had major depression and meet specific screening and medical rules.
Columbus, OhioAges 14–17 - NCT00025935Recruiting
Brain Function Studies in Youth With Mood and Attention Disorders
This research study examines how the brains of children and teenagers with mood problems (like persistent irritability or depression) or attention difficulties work differently. Researchers use brain scans and tasks to understand these conditions better and track changes as young people grow up.
Bethesda, MarylandAges 7–60 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT07404085Recruiting
Cognitive training with medication for mood disorders
This trial tests if a medication can boost the effects of cognitive training in people with bipolar disorder or recurrent depression who have memory or thinking problems. It aims to improve daily functioning.
Frederiksberg, Capital Region of DenmarkAges 40–75 - NCT06412315Recruiting
Brain scan and citalopram study for healthy volunteers
This study uses a powerful 7T MRI scanner to look at a part of the brain called the amygdala, and tests how the drug citalopram affects brain activity during emotional tasks. It may help researchers understand more about mood disorders.
Oxford, OxfordshireAges 18–40 - NCT07088939Recruiting
Online skills course for depression and anxiety
This trial tests an online course that teaches skills to manage emotions. It is for people in Ontario with mild depression or anxiety who are not currently in therapy.
Windsor, OntarioAges 18 years+ - NCT05427708Recruiting
Breathing training to reduce anxiety symptoms
This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.
Austin, TexasAges 18 years+ - NCT07072728RecruitingPhase 2
Psilocybin therapy for anxiety in cancer patients
This trial tests whether psilocybin (a psychedelic drug given with talk therapy) can help people with cancer who have adjustment disorder—a condition where a cancer diagnosis causes severe anxiety or stress. It focuses on reducing anxiety and improving emotional well-being.
Abbotsford, VictoriaAges 18–80 - NCT07212075Recruiting
Digital twin study for mental health in diabetes
This study uses digital twins—a virtual model of your health—to track how your mental health changes with diabetes. It aims to find patterns that could help personalize mental health care.
Bad Mergentheim, Baden-WurttembergAges 18–80 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT07120711Recruiting
Sleep apnea, thinking, and mood study for kids and adults
This study looks at how sleep apnea affects thinking and mood by checking certain proteins in the body. They want to see if these proteins can help predict or explain changes in memory, focus, or emotions.
ShanghaiAges 5 years+ - NCT07495189Enrolling by invitation
Mood, sleep, and brain study
This trial looks at how mood problems and sleep issues affect each other. It compares people with and without these conditions to understand the connection.
Jinan, ShandongAges 18–80 - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT06949813Recruiting
Preventing mood symptoms after C-section
This study tests a program to help prevent depression, anxiety, or trauma symptoms in people who have a cesarean delivery. It is for pregnant people who are in the hospital for at least 3 days before their C-section due to a high-risk pregnancy.
Aurora, ColoradoAges Any age - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100
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Common questions
- Are there clinical trials for mood disorders?
- Yes. Clin2 currently lists 80 recruiting mood disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mood disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mood disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.