Musculoskeletal Diseases clinical trials

Join a national survey database for musculoskeletal care

This trial builds and studies a national database that collects patient-reported outcomes (answers about symptoms and function) and patient/clinic information for musculoskeletal (muscle and joint) care. It may help improve how these services are delivered by showing what works in real-world primary/community care.

How gender affects physical activity for preventing joint pain

This study looks at how being male or female affects physical activity habits and how that might help prevent long-term muscle and joint problems. It is open to adults in Lombardy, Italy, who can speak Italian.

Study of melorheostosis progression and genetic causes

This study follows adults with suspected or confirmed melorheostosis to understand how the condition develops and what outcomes to expect. It may help researchers better understand the disease and its genetic factors.

Study of stem cells for several short- and long-term illnesses

This early-stage study tests whether injections of mesenchymal stem cells can be safe and helpful for certain chronic (long-term) and acute (short-term) conditions. You might be considered if you can consent, are able to return for follow-up visits, and do not have key reasons that would make stem-cell treatment unsafe.

Exercises at home for muscle and bone conditions

This study looks at how well people follow a home exercise program for muscle or bone problems. It aims to understand what helps or makes it hard to stick with the exercises.

Understanding Pain and Sexual Health in Chronic Pain

This study helps develop a questionnaire (survey) that measures how chronic pain affects sexual health and relationships. If you have long-term pain and a stable relationship, your feedback could help doctors better understand and support patients like you.

Understanding how rheumatic diseases develop over time

This research study follows people with known or suspected rheumatic diseases (like arthritis, lupus, or similar conditions) to learn how these conditions change and progress naturally. By tracking your health over time, researchers hope to better understand these diseases and improve treatments.

Validating a tool for muscle and joint care in physiotherapy

This study checks how well a tool (the ICF Core Set) helps physiotherapists evaluate people with muscle, bone, or joint problems in primary care. If you have a muscle or joint issue and speak Spanish, you may be able to help improve care for others.

Muscle and bone health in dentists

This study looks at muscle and bone problems in dentists who are either in advanced training or already specialists. Researchers want to find out how common these issues are and what might cause them.

Combining CT and MRI for joint pain procedure

This study tests a procedure called transarterial microembolization for chronic shoulder or knee pain that hasn't improved with other treatments. It uses both CT and MRI to guide the procedure and see if it can help reduce pain.

Steroid injection during total knee replacement

This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.

Compare two local anesthetics after foot nerve blocks

This study tests whether lidocaine or levobupivacaine works better for how a nerve block behaves after foot surgery. It may help doctors choose the anesthetic that provides more reliable pain control after surgery.

Finding the lowest safe anesthetic dose for shoulder surgery

This trial studies how much numbing medicine is needed for an ultrasound-guided nerve block used during elective shoulder rotator cuff surgery. It may help reduce side effects while still providing good pain control.

Exercise types and bone markers in healthy older veterans

This study compares different ways of exercising to see how they affect “bone-related” blood markers in older adults. It may help you and researchers understand which exercise patterns support healthy bones.

Testing two anesthesia types for arm surgery

This trial compares two methods of numbing the arm and chest area during upper-extremity surgery. It may help you and your care team choose the option that works best and feels easiest for breathing and movement.

Study of muscle loss in people with lipedema

This study looks at whether people with lipedema also have low muscle strength or muscle loss, and what factors might be related. It may help doctors better understand lipedema and identify targets for future care.

Exercise program for children with hemophilia A or B

This trial studies whether a structured exercise program helps children with hemophilia A or B safely. It looks at children’s ability to exercise and function, while aiming to avoid complications like leg bleeds or injuries.

New school program for childhood obesity and prediabetes

This study tests a new program to help children with obesity, focusing on those with slightly higher blood sugar (prediabetes). It takes place at a school and requires both parent and child consent.

Comparing two nerve block methods for lung surgery

This trial compares two techniques for numbing the chest during lung cancer surgery to see which provides better pain relief. It may help patients recover with less discomfort.

Plantar fascia embolization with SakuraBead for heel pain

This trial tests a new treatment for plantar fasciitis using tiny beads (SakuraBead) that are injected to block abnormal blood vessels and reduce pain. It may help people with chronic heel pain that hasn't improved with other treatments.

Monitoring patients after regenerative treatments for joint or tendon pain

This trial follows people who receive “regenerative medicine” treatments (orthobiologics) for joint or tendon problems, like osteoarthritis or tendon pain. The goal is to study whether clinical check-ins and lab/biologic measurements can help monitor how patients are doing after treatment.

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

Study how inflammatory muscle diseases naturally change over time

This study follows people with suspected or confirmed inflammatory muscle disease (and sometimes healthy adults) to better understand how the condition progresses and what changes over time. It may help researchers identify patterns that could guide future treatments.

Study of joint illness patterns and genes in juvenile and adult diseases

This study follows people with systemic juvenile idiopathic arthritis (sJIA), adult-onset Still’s disease (AOSD), and similar conditions to learn how the illness works over time. It also collects blood and family information to study genetics and explain what causes flare-ups, which may help future care.