Clinical trials
Negative Symptoms in Schizophrenia clinical trials
Below are recruiting negative symptoms in schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 23 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06127004Recruiting
Metacognitive training for negative symptoms
This study tests a training program designed to help people with schizophrenia or related conditions better manage challenging thoughts and feelings. It may be a good fit if you have trouble with motivation, social withdrawal, or low energy (negative symptoms).
Multiple LocationsAges 18 years+ - NCT07565428RecruitingPhase 3
Study of roluperidone for negative symptoms of schizophrenia
This trial tests a new medicine called roluperidone for people with schizophrenia who have ongoing negative symptoms (like low motivation or social withdrawal) but stable positive symptoms (like hallucinations). It aims to see if the drug helps with these symptoms and if it can reduce the chance of relapse compared to other medications.
Bellflower, CaliforniaAges 18–55 - NCT07074704Enrolling by invitation
Brain stimulation to improve symptoms and thinking in schizophrenia
This study tests whether a gentle electrical current applied to the scalp (transcranial alternating current stimulation, or tACS) can help reduce negative symptoms and improve thinking in people with long-term schizophrenia. It is for patients who have been hospitalized for over six months and are on stable medication.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06278532Recruiting
Validating psychosis assessment tools in Lithuanian
This trial tests whether three psychiatric questionnaires work well for people with schizophrenia or related disorders. If you are between 18 and 65 and have one of these diagnoses, joining may help improve care for others like you.
KaunasAges 18–65 - NCT06351514RecruitingPhase 3
Accelerated brain stimulation for negative symptoms of schizophrenia
This trial tests a faster form of brain stimulation called accelerated intermittent theta burst stimulation to help with persistent negative symptoms of schizophrenia. Negative symptoms include things like lack of motivation, reduced emotion, or social withdrawal.
SingaporeAges 21–65 - NCT06588270Recruiting
Virtual reality therapy for schizophrenia symptoms
This study tests whether using virtual reality (VR) can help improve the 'negative symptoms' of schizophrenia, like low motivation or social withdrawal. You would play specially-designed VR games during therapy sessions to see if it helps you feel more engaged.
Santiago, Santiago MetropolitanAges 18–65 - NCT06595654Recruiting
rTMS for negative symptoms of schizophrenia
This trial tests if repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help reduce negative symptoms of schizophrenia like lack of motivation or social withdrawal. It might be an option if your negative symptoms are more prominent than positive ones.
Neuilly-sur-MarneAges 18 years+ - NCT06642675Recruiting
Brain stimulation for negative symptoms in schizophrenia
This trial tests whether a non-invasive brain stimulation technique called nTMS (repetitive transcranial magnetic stimulation) can help reduce negative symptoms of schizophrenia, like lack of motivation or social withdrawal. It's a possible treatment option for people with stable schizophrenia who still struggle with these symptoms.
Changsha, HunanAges Up to 60 years - NCT06888726Recruiting
Brain stimulation for negative symptoms in schizophrenia
This trial tests if a gentle electric current applied to your head can help with negative symptoms (like lack of motivation or emotion). You must have schizophrenia, take a common antipsychotic, and have some ongoing negative symptoms.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06907420Recruiting
40 Hz visual stimulation for schizophrenia
This trial tests whether a specific type of flickering light (40 Hz) can help people with schizophrenia or schizoaffective disorder. The treatment is non-invasive and may improve brain function.
Munich, BavariaAges 18 years+ - NCT07680959Enrolling by invitation
Brain stimulation for negative symptoms of schizophrenia
This trial tests combining two types of non-invasive brain stimulation (HD-tDCS and iTBS) to help with negative symptoms of schizophrenia, such as lack of motivation or social withdrawal. The goal is to see if this combination can improve these symptoms that are often hard to treat with medication alone.
TaipeiAges 18–65 - NCT07428460Recruiting
Speedy brain stimulation for persistent negative symptoms in schizophrenia
This trial tests if a new, faster form of brain stimulation called accelerated neuromodulation therapy can help reduce negative symptoms (like loss of motivation or social withdrawal) in people with schizophrenia. It aims to see if this treatment can improve daily functioning and quality of life.
Montreal, QuebecAges 18–65 - NCT07559084Recruiting
Brain Stimulation for Schizophrenia Negative Symptoms
This trial tests a newer form of brain stimulation called multi-target TMS (transcranial magnetic stimulation) to help reduce negative symptoms of schizophrenia—like reduced emotion, motivation, and speech—in people whose symptoms aren't fully controlled by medication alone.
Shanghai, Shanghai MunicipalityAges 16–45 - NCT07356765Enrolling by invitation
Berberine for negative symptoms of schizophrenia
This trial tests if berberine, a natural supplement, can help reduce negative symptoms like lack of motivation or social withdrawal in people with schizophrenia. It may work by affecting the brain and body.
TianjinAges 18–60 - NCT07290738Recruiting
TMS for negative symptoms in schizophrenia
This study tests whether a non-invasive brain stimulation technique called TMS can help reduce negative symptoms in people with schizophrenia. These symptoms include things like lack of motivation, limited speech, and not expressing emotions.
Houston, TexasAges 18–60 - NCT06740747Recruiting
Brain stimulation for schizophrenia symptoms
This study tests a new type of brain stimulation (called intermittent theta-burst stimulation) to see if it helps with symptoms like lack of motivation or trouble thinking clearly in people with schizophrenia. You will also have an MRI scan to see how the brain changes.
Hanover, Lower SaxonyAges 18–65 - NCT04789915RecruitingPhase 1
Testing memantine added to dopamine-targeting treatment for early psychosis
This Phase 1 study tests whether adding memantine can improve “negative symptoms” (like low motivation, reduced emotional expression) in people having their first episode of psychosis. It’s designed to understand safety and early effects when dopamine-related treatment is adjusted.
Glostrup Municipality, Capitol RegionAges 18–45 - NCT07058389Recruiting
Exercise in green spaces for schizophrenia symptoms
This study tests whether combining physical activity with being in green outdoor spaces can reduce the tough symptoms of schizophrenia, like feeling flat or unmotivated. It's designed for people whose negative symptoms are not going away.
Saint-Etienne, FranceAges 18–55 - NCT05671185Recruiting
Brain stimulation for schizophrenia symptoms and depression
This study tests repeated brain stimulation (rTMS) to see if it can improve symptoms of schizophrenia and related depression, and measure body/brain changes. You may be considered if you have schizophrenia or schizoaffective disorder with enough depressive symptoms, and if recent treatments and medical safety factors fit the rules.
Douliu, YunlinAges 20 years+ - NCT04226898RecruitingPhase 2
Synbiotic supplement to lessen schizophrenia symptoms
This Phase 2 trial tests whether a “synbiotic” supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia or schizoaffective disorder. It may help by targeting gut-related immune and inflammation pathways that could affect brain symptoms.
Batlimore, MarylandAges 18–65 - NCT06482554RecruitingPhase 3
Lumateperone for Apathy in Psychotic Disorders
This trial tests a medication called lumateperone to see if it can improve apathy (lack of motivation) in people who have psychotic symptoms from schizophrenia or related disorders. It may help if you are already on a stable treatment but still struggle with apathy.
Shreveport, LouisianaAges 18–65 - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT03094429RecruitingPhase 2/Phase 3
Testing NaBen add-on to clozapine for tough schizophrenia symptoms
This trial tests whether adding NaBen (a supplement-like medicine) to clozapine can improve “residual” symptoms in adults with difficult-to-treat schizophrenia. The study also checks safety and the best dose, using a placebo (inactive pill) for comparison.
Pasadena, CaliforniaAges 18–55
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Common questions
- Are there clinical trials for negative symptoms in schizophrenia?
- Yes. Clin2 currently lists 23 recruiting negative symptoms in schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a negative symptoms in schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a negative symptoms in schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.