Clinical trials · Boston, MA
Opioid Use Disorder clinical trials in Boston
We’re tracking 27 recruiting opioid use disorder studies with a site in or near Boston — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Boston, MassachusettsAges 18–75 - NCT06001749RecruitingPhase 2
Psilocybin for cancer pain study
This trial tests whether psilocybin (a psychedelic drug) can help with severe cancer pain. You may qualify if your pain is high despite strong medications and you are willing to be monitored closely.
Boston, MassachusettsAges 18 years+ - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Boston, MassachusettsAges 12–17 - NCT06323824RecruitingPhase 4
Methadone vs. buprenorphine for opioid use disorder treatment
This study compares two medications, methadone and buprenorphine, to see which helps people stay in treatment for opioid use disorder. You may be eligible if you are starting a new treatment episode.
Boston, MassachusettsAges 18–99 - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT04375033RecruitingPhase 4
Oral versus injection buprenorphine for opioid use disorder
This trial compares taking buprenorphine by mouth versus as an injection for opioid use disorder. It aims to see which option helps people stay on treatment and reduces opioid use over about a year.
Boston, MassachusettsAges 18 years+ - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+ - NCT06732596Recruiting
Recovery support app for people on buprenorphine
This study tests a smartphone app that uses a conversational helper to support people in recovery from opioid use disorder who are taking buprenorphine. It aims to help you stay on track with treatment.
Boston, MassachusettsAges 18 years+ - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06639464RecruitingPhase 2
Semaglutide to help with opioid recovery
This trial tests if semaglutide, a medicine sometimes used for weight management, can help people recovering from opioid use disorder stay on track. It is for adults who have already started buprenorphine treatment and are ready to take part in a research study.
Boston, MassachusettsAges 18 years+ - NCT07010978Recruiting
Testing recovery community centers for people on medication for opioid use disorder
This study tests whether recovery community centers (RCCs) help people who are taking medication for opioid use disorder (MOUD) stay in recovery. If you are on MOUD and live near a center that serves a Black community, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT07232641Recruiting
How pandemic rules affected opioid addiction treatment in the VA
This study looks at how changes in federal and state rules about medications for opioid use disorder during the pandemic affected veterans. It uses information already in your VA records, so there are no extra visits or tests needed.
Boston, MassachusettsAges 18 years+ - NCT07092059Recruiting
Smartphone app for stimulant use disorder
This study tests if a smartphone app can help people with stimulant use disorder stay on track. It may be a good option if you're leaving inpatient care or starting outpatient treatment.
Boston, MassachusettsAges 18 years+ - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT05817825Recruiting
Remote program to support recovery after opioid use
This study tests a new intensive outpatient program delivered by video or phone to help people with opioid use disorder (and other substance use disorders) stay on track after leaving the hospital. It may help by offering structured support while you are at home.
Boston, MassachusettsAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Cambridge, MassachusettsAges 18–85 - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Worcester, MassachusettsAges 18 years+ - NCT06655883RecruitingPhase 3
Testing suvorexant for insomnia in people with opioid use disorder
This study tests whether the sleep medication suvorexant (Belsomra) can help people with opioid use disorder who also have trouble sleeping. If you are stable on medication for opioid use disorder and have not used opioids in the last month, this trial may be an option for you.
Providence, Rhode IslandAges 18–70 - NCT06432465Recruiting
Brain stimulation to help prevent opioid relapse
This study uses a type of brain stimulation called tDCS (transcranial direct current stimulation) to see if it can help people who have recently started medication for opioid dependence (buprenorphine or methadone) stay on track and avoid relapse. The treatment is non-invasive and involves a mild electrical current applied to the scalp.
Providence, Rhode IslandAges 21–60 - NCT06320015Recruiting
Peer support for recovery after an emergency visit
This trial tests whether a peer recovery worker can help adults who came to the emergency room for a drug- or alcohol-related problem stay engaged in recovery. If you join, you'll get extra support from someone who has been through similar experiences.
Providence, Rhode IslandAges 18 years+ - NCT07778394Recruiting
Smartphone app to support recovery from opioid use disorder
This study is testing a smartphone app to help people who are starting or restarting medication for opioid use disorder. If you join, you'll use the app to support your recovery journey.
Providence, Rhode IslandAges 22 years+ - NCT04978168Recruiting
Peer support and opioid treatment help for people on probation
This study tests whether adding peer recovery support and coordinated opioid treatment support can improve care for people with opioid use disorder (OUD) who are on probation. It also trains and involves probation and treatment staff to better support clients over 12 months.
Providence, Rhode IslandAges 18 years+
Hear when a new Opioid Use Disorder trial opens near Boston, MA
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Opioid Use Disorder trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting opioid use disorder studies listed above.
- Boston Medical Center · 5 studies
- Brigham and Women's Hospital · 4 studies
- Massachusetts General Hospital · 3 studies
- Brown University · 2 studies
- Butler Hospital · 2 studies
- Rhode Island Hospital · 2 studies
- Adams Clinical
- At-Home Study (6 Liberty Sq, #2102)
What taking part in a opioid use disorder study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting opioid use disorder studies in Massachusetts.
Common questions
- Are there opioid use disorder clinical trials near Boston?
- Yes. We're currently tracking 27 recruiting opioid use disorder studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a opioid use disorder study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New opioid use disorder studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.