Clinical trials · Philadelphia, PA
Opioid Use Disorder clinical trials in Philadelphia
We’re tracking 27 recruiting opioid use disorder studies with a site in or near Philadelphia — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT07620171Enrolling by invitation
Peer Support to Help You Stay in Opioid Treatment
This study tests whether talking regularly with someone who has recovered from opioid addiction helps you stay in buprenorphine treatment longer. Buprenorphine is a medication that reduces cravings and withdrawal, and peer support may help you stick with it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Philadelphia, PennsylvaniaAges 18–75 - NCT06969261Recruiting
Chatbot to support pregnant women with opioid use disorder
This study tests a chatbot to help pregnant and new mothers being treated for opioid use disorder. The goal is to provide extra support and information during and after pregnancy.
Philadelphia, PennsylvaniaAges Any age - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT06559995RecruitingPhase 2/Phase 3
Ketone drink for alcohol withdrawal
This study tests whether a special ketone drink can ease alcohol withdrawal and help your brain heal. If you have been drinking heavily for at least 3 years and are having withdrawal symptoms now, this might be an option for you.
Philadelphia, PennsylvaniaAges 18–65 - NCT06576323Recruiting
Support for mothers with opioid use disorder and babies in the NICU
This study aims to improve care for mothers with opioid use disorder and their babies with neonatal abstinence syndrome. Researchers will interview healthcare providers and mothers to develop better support programs.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04978168Recruiting
Peer support and opioid treatment help for people on probation
This study tests whether adding peer recovery support and coordinated opioid treatment support can improve care for people with opioid use disorder (OUD) who are on probation. It also trains and involves probation and treatment staff to better support clients over 12 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06655883RecruitingPhase 3
Testing suvorexant for insomnia in people with opioid use disorder
This study tests whether the sleep medication suvorexant (Belsomra) can help people with opioid use disorder who also have trouble sleeping. If you are stable on medication for opioid use disorder and have not used opioids in the last month, this trial may be an option for you.
Philadelphia, PennsylvaniaAges 18–70 - NCT07217197Enrolling by invitation
A monitor to detect breathing problems after surgery
This trial tests a new respiratory monitoring system to see if it can detect and predict opioid-induced respiratory depression (OIRD) — when pain medicines slow your breathing too much — in patients recovering from surgery. The monitor uses a face mask, nasal cannula, and small sensors to track breathing continuously, so that doctors can step in early if there is a problem.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06786325RecruitingPhase 2
Psilocybin treatment study for opioid use disorder
This trial tests whether psilocybin can help people recovering from opioid use disorder while living at a residential treatment center. If you are already taking buprenorphine/naloxone (Suboxone), methadone, or have received Sublocade, this study may be an option for you.
Philadelphia, PennsylvaniaAges 18–60 - NCT05995535RecruitingPhase 2
Pregabalin and Lofexidine for Opioid Withdrawal
This study tests whether combining two medications, pregabalin and lofexidine, can help people stop using opioids by easing withdrawal symptoms. It's for adults who use opioids heavily and want to switch to a non-addictive blocker medication.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06643988Recruiting
Memory and thinking study for opioid use disorder
This study looks at how people with opioid use disorder remember personal events. You'll do tasks on a cellphone and at home while taking medication for opioid use disorder.
Philadelphia, PennsylvaniaAges 18–60 - NCT07787039Recruiting
Support program for opioid recovery after giving birth
This study tests a program that helps women who recently gave birth and are recovering from opioid use disorder. It brings in a support person (like a friend or family member) to help you stay on track with your recovery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07262190Recruiting
NavSTAR program for opioid use disorder
This trial tests a program to help people with opioid use disorder start or continue treatment while in the hospital. It aims to connect patients to care after they leave.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06173973Enrolling by invitationPhase 2/Phase 3
Ketone supplement for alcohol withdrawal symptoms
This study tests whether a special supplement (ketones) can help people feel better during alcohol withdrawal. It is for adults who are already in a treatment program for alcohol withdrawal.
Philadelphia, PennsylvaniaAges 18–75 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Philadelphia, PennsylvaniaAges 12–17 - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04616781RecruitingPhase 2/Phase 3
Ketone drink study for alcohol use disorder brain function
This study tests whether a ketone-based treatment (a ketone ester) can change brain activity in people with alcohol use disorder who are not currently seeking treatment. You may also have brain scans, so the study is looking for safe MRI eligibility and certain health factors.
Philadelphia, PennsylvaniaAges 21–65 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07475728Recruiting
Buprenorphine for Opioid Use Started by Emergency Medical Services
This study looks at offering buprenorphine through emergency medical services (EMS) to people having an opioid emergency. It aims to see if starting treatment in the field helps people get connected to long-term care.
Camden, New JerseyAges Any age - NCT06494904RecruitingPhase 3
Standard vs. High Dose Buprenorphine in the ER
This study compares a higher dose of buprenorphine (a medicine that helps stop opioid cravings and withdrawal) to the usual dose, given in the emergency department. It aims to see if the higher dose works better to start treatment for opioid use disorder.
Camden, New JerseyAges 18–65
Hear when a new Opioid Use Disorder trial opens near Philadelphia, PA
We’ll email you when one opens near Philadelphia, PA — at most once a week, no account needed, unsubscribe anytime.
Opioid Use Disorder trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting opioid use disorder studies listed above.
- University of Pennsylvania · 6 studies
- University of Pennsylvania Center for Studies of Addiction · 4 studies
- Cooper University Hospital · 2 studies
- Adams Clinical
- Center for Studies of Addiction
- Children's Hospital of Philadelphia
- Hassman Research Institute Marlton Site ( Site 2005)
- Hospital of the University of Pennsylvania
What taking part in a opioid use disorder study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting opioid use disorder studies in Pennsylvania.
Common questions
- Are there opioid use disorder clinical trials near Philadelphia?
- Yes. We're currently tracking 27 recruiting opioid use disorder studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a opioid use disorder study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New opioid use disorder studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.