Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 295 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06712602RecruitingPhase 1
Testing PT150 for Alcohol Use Disorder
This study tests whether a drug called PT150 can help people with moderate to severe alcohol use disorder who are not currently seeking treatment. You will be asked to stay abstinent from alcohol for short periods and attend sessions to see how PT150 affects your body and alcohol cravings.
Lexington, KentuckyAges 21–55 - NCT06642181RecruitingPhase 1
Guanfacine and meditation with buprenorphine for opioid use disorder
This study tests if adding a medication called guanfacine and mindfulness meditation to standard buprenorphine treatment helps people with opioid use disorder. It looks at whether this combination can improve treatment outcomes and reduce opioid use.
Newark, New JerseyAges 18–55 - NCT06689072Enrolling by invitation
High-frequency brain stimulation for opioid use disorder
This study tests whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help people with opioid use disorder. It involves a non-invasive procedure that uses magnetic pulses to stimulate certain parts of the brain.
Asyut, Asyut GovernorateAges 18–45 - NCT06655883RecruitingPhase 3
Testing suvorexant for insomnia in people with opioid use disorder
This study tests whether the sleep medication suvorexant (Belsomra) can help people with opioid use disorder who also have trouble sleeping. If you are stable on medication for opioid use disorder and have not used opioids in the last month, this trial may be an option for you.
Garden Grove, CaliforniaAges 18–70 - NCT06651333Recruiting
Brain scans during opioid addiction treatment
This study uses brain scans to understand how methadone or buprenorphine treatment affects the brain, with the goal of helping people stay in treatment and avoid relapse. You would need to be recently started on one of these medications and be able to undergo MRI scans.
Hartford, ConnecticutAges 18–50 - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06643988Recruiting
Memory and thinking study for opioid use disorder
This study looks at how people with opioid use disorder remember personal events. You'll do tasks on a cellphone and at home while taking medication for opioid use disorder.
Philadelphia, PennsylvaniaAges 18–60 - NCT06641115Recruiting
Integrated treatment for opioid use disorder and PTSD
This study tests a combined therapy for people with both opioid use disorder and PTSD. It aims to help you manage both conditions together, rather than treating them separately.
Charleston, South CarolinaAges 18–70 - NCT06639464RecruitingPhase 2
Semaglutide for improving opioid recovery outcomes
This study tests whether semaglutide (a medication used for weight management) can help people on buprenorphine or methadone reduce their opioid use. If it works, it could provide additional support during recovery.
Boston, MassachusettsAges 18 years+ - NCT06617949RecruitingEarly Phase 1
Pain Control Study for New Mothers on Opioid Medication
This study looks at better ways to manage pain after childbirth for mothers who are taking medication for opioid use disorder. It aims to find which pain control method works best and is safest for you and your baby.
Milwaukee, WisconsinAges 18–40 - NCT06593353Recruiting
Improving opioid use disorder care for people leaving jail
This study tests a system to improve care for people with opioid use disorder as they leave jail and return to the community. It aims to help patients stay in treatment and avoid interruptions.
Seattle, WashingtonAges 18–110 - NCT06593093RecruitingPhase 1/Phase 2
Continuing buprenorphine after an overdose emergency
This study tests a bundled approach to help adults who have had an opioid overdose and are starting buprenorphine in the emergency department continue their recovery after being discharged. It is for people who want to stay on buprenorphine and need support after leaving the hospital.
Birmingham, AlabamaAges 19 years+ - NCT06585709Recruiting
Brain stimulation for opioid use disorder treatment
This trial tests if brain stimulation can help people starting buprenorphine for opioid use disorder. It aims to improve treatment outcomes and support recovery.
Durham, North CarolinaAges 18 years+ - NCT06576323Recruiting
Support for mothers with opioid use disorder and babies in the NICU
This study aims to improve care for mothers with opioid use disorder and their babies with neonatal abstinence syndrome. Researchers will interview healthcare providers and mothers to develop better support programs.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06573476Recruiting
Smartphone app and peer coach for opioid treatment
This study tests whether a smartphone app and support from a peer recovery coach can help Black and Latinx individuals with opioid use disorder start buprenorphine treatment. The goal is to reduce overdose deaths and address racial gaps in care.
New York, New YorkAges 18–99 - NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06538558RecruitingPhase 1
Study of tezampanel for opioid withdrawal
This trial tests if tezampanel can help relieve withdrawal symptoms in people with opioid use disorder who are seeking treatment. Participants must already be in an outpatient addiction program.
Indianapolis, IndianaAges 18–65 - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT06521476RecruitingPhase 2
Acetazolamide for sleep apnea in people on opioid treatment
This trial tests if a drug called acetazolamide can help people with central sleep apnea who are also on medication for opioid use disorder. Sleep apnea causes breathing to stop during sleep, and this study aims to see if the drug improves their sleep breathing.
Pittsburgh, PennsylvaniaAges 18–100 - NCT06526286Recruiting
Support to help you use medications for opioid use disorder
This trial tests if a computer tool can help doctors prescribe medications for opioid use disorder during regular checkups. It may be right for you if you take prescription opioids for pain or have had issues with opioids.
Aurora, ColoradoAges 12–89 - NCT06513156Recruiting
Care support for hospitalized patients with drug-related infections
This study is for people who are in the hospital with a serious infection caused by injection drug use. It aims to provide better care and support while you are in the hospital and after you leave.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06487533Recruiting
Sensing opioid withdrawal and cravings with wearable sensors
This study uses wearable sensors to track physical signs of opioid withdrawal and cravings over 14 days. It aims to better understand these symptoms in people currently taking or planning to start medication for opioid use disorder.
Center City, MinnesotaAges 18–50 - NCT06477848Enrolling by invitation
Improving care for teens with opioid use disorder in pediatric clinics
This study looks at how to better support teens with opioid use disorder in pediatric primary care. It involves training clinic staff and gathering feedback from both providers and patients.
Indianapolis, IndianaAges 12 years+ - NCT06454903Recruiting
Smartphone app support for veterans treating opioid use disorder
This study tests a smartphone app to support Veterans in their recovery from opioid use disorder. The app aims to improve daily functioning alongside medication treatment.
West Haven, ConnecticutAges 18 years+
Hear when a new Opioid Use Disorder trial opens
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 295 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.