Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 280 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06477848Enrolling by invitation
Improving care for teens with opioid use disorder in pediatric clinics
This study looks at how to better support teens with opioid use disorder in pediatric primary care. It involves training clinic staff and gathering feedback from both providers and patients.
Indianapolis, IndianaAges 12 years+ - NCT07620171Enrolling by invitation
Peer Support to Help You Stay in Opioid Treatment
This study tests whether talking regularly with someone who has recovered from opioid addiction helps you stay in buprenorphine treatment longer. Buprenorphine is a medication that reduces cravings and withdrawal, and peer support may help you stick with it.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06642181RecruitingPhase 1
Guanfacine and meditation with buprenorphine for opioid use disorder
This study tests if adding a medication called guanfacine and mindfulness meditation to standard buprenorphine treatment helps people with opioid use disorder. It looks at whether this combination can improve treatment outcomes and reduce opioid use.
Newark, New JerseyAges 18–55 - NCT06641115Recruiting
Integrated treatment for opioid use disorder and PTSD
This study tests a combined therapy for people with both opioid use disorder and PTSD. It aims to help you manage both conditions together, rather than treating them separately.
Charleston, South CarolinaAges 18–70 - NCT06585709Recruiting
Brain stimulation for opioid use disorder treatment
This trial tests if brain stimulation can help people starting buprenorphine for opioid use disorder. It aims to improve treatment outcomes and support recovery.
Durham, North CarolinaAges 18 years+ - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT06434233RecruitingPhase 4
Opioid use after fallopian tube removal surgery
This study looks at how much opioid pain medicine people need after having their fallopian tubes removed through small incisions (laparoscopic or robotic salpingectomy). It aims to see if the usual pain medicine can be reduced to decrease opioid use.
Baltimore, MarylandAges 18 years+ - NCT05942313Recruiting
Predicting and preventing problems from opioid use during pregnancy
This study looks at ways to predict and reduce harmful outcomes for pregnant people with opioid use disorder (OUD) and their babies. It focuses on people who are already receiving ongoing medication treatment during pregnancy and will follow them around delivery at a specific hospital.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05683184RecruitingPhase 1
Brain imaging study for opioid use disorder
This study uses brain scans to understand opioid use disorder better. If you have opioid addiction, you might be eligible to help researchers learn more about how the brain is affected.
New Haven, ConnecticutAges 18 years+ - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT07079215Recruiting
Device trial for opioid withdrawal symptoms
This trial tests a physical device (ADTPM 1) to help manage withdrawal symptoms in people who are dependent on opioids. The goal is to see if the device can safely reduce withdrawal discomfort.
Daegu, DaeguAges 19–80 - NCT07169409RecruitingPhase 1
Telehealth for opioid use disorder in vulnerable settings
This trial tests whether a telehealth program can help people with opioid use disorder get and stay on buprenorphine treatment. It aims to make care more accessible for those in vulnerable situations.
Portland, OregonAges 18 years+ - NCT06880718RecruitingPhase 4
Injectable buprenorphine for opioid use disorder in prison
This study tests whether a once-monthly injection of buprenorphine (called extended-release buprenorphine, or XR-B) works well for people in prison who are already in a medication program for opioid use disorder. It looks at preferences and outcomes in the last months before release.
Cranston, Rhode IslandAges 18 years+ - NCT05665179Recruiting
Community program for people receiving addiction treatment
This trial is focused on people who are currently getting treatment for substance use disorder. It aims to test community partnership approaches that reduce barriers and improve support during recovery.
Ann Arbor, MichiganAges 18 years+ - NCT07673380RecruitingPhase 2
Mobile health for opioid recovery and mental health
This study uses a mobile health app to help Black and African American individuals recover from opioid or stimulant use and improve mental health. It aims to see if the app can support treatment and well-being.
St Louis, MissouriAges 18 years+ - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07485335RecruitingPhase 4
Overdose prevention support after emergency department care
This study tests a package of support services to help people who have had an opioid overdose and are starting buprenorphine in the emergency department. The goal is to keep them safe and reduce the chance of another overdose.
Birmingham, AlabamaAges 19 years+ - NCT06507293Recruiting
Pain relief methods comparison for lung surgery
This trial tests two numbing injections to see which reduces pain medicine use during lung surgery. A special pain monitor guides the treatment. It may help you need fewer opioids during your procedure.
KocaeliAges 18–65 - NCT07278518Recruiting
Emergency department decision aid for buprenorphine
This trial is testing a tool to help people in the emergency department decide whether to start buprenorphine (a medication for opioid use disorder). It's for patients who are not already on medication for their condition.
Charleston, South CarolinaAges 18 years+ - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT06311838Recruiting
Preventing opioid use among homeless youth
This study tests a program to help homeless youth build social connections and find stable housing to prevent opioid use. It will be conducted by Ohio State University.
Columbus, OhioAges 14–24 - NCT05711056Recruiting
Telehealth help to start and link treatment for opioid use disorder
This program offers telehealth support to help you start opioid use disorder treatment and get connected to ongoing care, using toxicology/medical specialists. It may help if you’re in a stable, sober condition and not already on similar treatment.
Atlanta, GeorgiaAges 18 years+ - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06513156Recruiting
Care support for hospitalized patients with drug-related infections
This study is for people who are in the hospital with a serious infection caused by injection drug use. It aims to provide better care and support while you are in the hospital and after you leave.
Washington D.C., District of ColumbiaAges 18 years+
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Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 280 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.