Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 280 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT07569783Recruiting
Can brain stimulation reduce itching after C-section?
This study tests whether a gentle brain stimulation technique (tDCS) can reduce itching after a C-section. It is for women who are having a C-section with epidural anesthesia and morphine.
Nantong, JiangsuAges 18–40 - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07768007Recruiting
Methadone and memory study for opioid use disorder
This study tests whether a new approach can improve memory and mood in people taking methadone for opioid use disorder. It involves brain scans and may help with feelings of sadness or loss of interest.
New Haven, ConnecticutAges 18–50 - NCT07457489Recruiting
Brain stimulation for opioid recovery
This study tests a non-invasive brain stimulation technique called TMS to see if it can reduce opioid cravings and help people who are already taking buprenorphine stay in recovery. TMS uses magnetic pulses to stimulate parts of the brain involved in addiction.
Brentwood, TennesseeAges 18–65 - NCT07365293Recruiting
Support for Families Affected by Opioid or Meth Use
This study tests a program that helps parents who are using opioids or methamphetamines get support for themselves and their families. It may be a good fit if you have Medicaid, live in certain counties, and are open to working with a coach.
Eugene, OregonAges Any age - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT06706375Recruiting
Comparing two types of penile nerve blocks for child circumcision
This study tests two ways of numbing the penis before circumcision in children. The goal is to see which method works better and causes less discomfort.
Lausanne, Canton of VaudAges Up to 17 years - NCT07586917Recruiting
Supporting Pregnant People with Opioid Use Disorder
This study helps pregnant people who struggle with opioid use and are starting or considering medication treatment. Researchers will track your health and your baby's health to learn how to best support you during and after pregnancy.
Salt Lake City, UtahAges 18 years+ - NCT05973838Recruiting
Telemedicine support plus recovery coaching for multiple drug use
This study tests whether adding peer recovery support to a phone/video treatment program helps people stay in treatment longer and reduce polysubstance use. It focuses on adults in opioid use disorder care who have used other non-prescribed substances in the last three months.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04939623RecruitingPhase 2
Probenecid to ease opioid withdrawal symptoms while tapering
This Phase 2 study tests whether probenecid can lessen discomfort from opioid withdrawal in adults who are gradually lowering their opioid pain medicine. If it works, it may make tapering feel more tolerable and safer.
Calgary, AlbertaAges 18–80 - NCT06795087Recruiting
Medication Use After Genitourinary Cancer Surgery
This study looks at the medications patients take after surgery for bladder, kidney, or prostate cancer. The goal is to understand how these medications are used and help improve recovery.
Charlotte, North CarolinaAges 18 years+ - NCT07552766RecruitingPhase 4
Lidocaine infusion to reduce opioid use in arm fracture surgery
This study tests whether giving a pain-relieving medication called lidocaine through an IV during arm fracture surgery can reduce how much opioid pain medication (like morphine) children need after surgery. The goal is to help manage pain better while using fewer opioids.
Wilmington, DelawareAges 3–18 - NCT07032987Recruiting
Improving sedation with a new care plan for ICU patients
This trial tests a new sedation protocol for adults in intensive care who need strong pain relief or sedation medicines. It aims to make sedation safer and more comfortable, and includes people on ECMO (a heart-lung machine) or a ventilator (breathing machine) for severe breathing problems.
London, LondonAges 18–100
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Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 280 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.