Clinical trials · Raleigh–Durham, NC
Pain clinical trials in Raleigh–Durham
We’re tracking 36 recruiting pain studies with a site in or near Raleigh–Durham — including Phase 1/Phase 2, Phase 2 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Raleigh–Durham
- NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT05991453Recruiting
Recovery after IV vs. inhaled anesthesia for non-cardiac surgery
This trial compares recovery after two types of general anesthesia: one given through an IV (propofol) and one inhaled as a gas. It aims to see which approach leads to a smoother recovery for people having non-cardiac surgery.
Durham, North CarolinaAges 18 years+ - NCT06228755Enrolling by invitation
Study on group integrative care for chronic pain
This study looks at how well group medical visits that combine different treatments (like mind-body approaches) work for people with chronic pain. It aims to make these visits more available and helpful.
Chapel Hill, North CarolinaAges 18 years+ - NCT07337902Recruiting
Comparing pain medicines for menstrual cramps in Crohn’s disease
This study tests two common over-the-counter pain relievers (ibuprofen and acetaminophen) to see which works better for menstrual cramps in women who also have Crohn's disease while in remission. If you have Crohn's and painful periods, this may help you find a safer option.
Chapel Hill, North CarolinaAges 18–44 - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Chapel Hill, North CarolinaAges 18 years+ - NCT07245303Recruiting
How Light Affects Pain in Chronic Pain
This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT07479199Recruiting
Radiofrequency ablation and radiation for painful spine tumors
This trial tests a treatment that uses heat (radiofrequency ablation) and radiation to relieve pain from tumors in the spine. It may help if you have cancer that has spread to your upper or lower back and you have moderate to severe pain.
Chapel Hill, North CarolinaAges 18 years+ - NCT07191067Recruiting
Study of NOVABLOC system for knee replacement pain
This trial tests a new device called the NOVABLOC system to see if it helps control pain during and after knee replacement surgery. It is for people with osteoarthritis who are having their first knee replacement on one knee.
Chapel Hill, North CarolinaAges 21 years+ - NCT07095036Recruiting
Spinal cord stimulation and sensation study
This study looks at how a spinal cord stimulator affects your sense of touch and movement. It may help doctors better understand how this device works for people with chronic pain.
Chapel Hill, North CarolinaAges 18–85 - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Chapel Hill, North CarolinaAges 18 years+ - NCT06168058Recruiting
Pelvic vein embolization for chronic pelvic pain
This trial tests if blocking enlarged veins in the pelvis (called embolization) can reduce long-term pelvic pain that hasn't improved with other treatments. It may help women whose pain is worse when standing or walking and better when lying down.
Chapel Hill, North CarolinaAges 18–75 - NCT06853327Enrolling by invitationPhase 2
Ketorolac for pain during IUD insertion
This study tests if a pain-relief medicine, ketorolac, helps reduce pain when getting an IUD placed. It might be an option if you are planning to have an IUD inserted.
Hillsborough, North CarolinaAges 18 years+
Hear when a new Pain trial opens near Raleigh–Durham, NC
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Pain trials in other cities
Where these studies are running near Raleigh–Durham
Institutions with a site for the recruiting pain studies listed above.
- University of North Carolina at Chapel Hill · 5 studies
- UNC School of Medicine · 2 studies
- Ambulatory Care Center
- Duke North Pavilion
- Duke University
- UNC Children's Hospital
- University of North Carolina Hospitals - Hillsborough Campus
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pain studies in North Carolina.
Common questions
- Are there pain clinical trials near Raleigh–Durham?
- Yes. We're currently tracking 36 recruiting pain studies with a site near Raleigh–Durham, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study near Raleigh–Durham?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Raleigh–Durham to take part?
- Not necessarily. These studies have a site near Raleigh–Durham, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open near Raleigh–Durham regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.