Clinical trials
Persistent Corneal Epithelial Defect clinical trials
Below are recruiting persistent corneal epithelial defect clinical trials, each written for real people, not researchers. We’re tracking 5 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05966493RecruitingPhase 2
Lufepirsen gel for persistent corneal epithelial defects
This Phase 2 trial tests whether a treatment gel called NEXAGON (lufepirsen) can improve healing and safety in people with a persistent corneal problem called PCED that hasn’t gotten better despite standard non-surgical treatments. You may be a candidate if your defect has lasted at least 2 weeks and hasn’t improved recently, and if you don’t have certain eye infections or other eye conditions.
Dothan, AlabamaAges 2 years+ - NCT03653650Recruiting
Platelet-rich plasma for stubborn corneal surface wounds
This trial studies injecting your own platelet-rich plasma into the eye to help a persistent corneal surface defect heal. It may help if you have a recurring or nerve-related corneal ulcer, but it’s not for certain ulcer types or active eye infections.
Monterrey, Nuevo LeónAges Any age - NCT07561398RecruitingPhase 4
Insulin drops vs amniotic membrane for stubborn corneal sores
This trial compares two treatments for persistent corneal surface wounds that haven't healed with standard care. You'll receive either insulin eye drops or a special tissue graft to help your cornea heal.
Rawalpindi, Punjab ProvinceAges 16–70 - NCT07519902RecruitingPhase 3
Cenegermin Eye Drops for Persistent Corneal Ulcers
This study tests whether cenegermin eye drops help heal stubborn corneal ulcers (open sores on the clear front of the eye) that haven't improved with standard treatments like lubricating drops or contact lenses.
Huntington Beach, CaliforniaAges 18 years+ - NCT06919081RecruitingPhase 2
Stem cell eye drops for chronic cornea problems
This study tests whether a special substance from stem cells (called secretome) can help heal chronic surface problems on the eye that haven't gotten better with standard treatments. It's for people with a stubborn scratch or defect on the cornea that has lasted more than 14 days.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for persistent corneal epithelial defect?
- Yes. Clin2 currently lists 5 recruiting persistent corneal epithelial defect studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent corneal epithelial defect trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent corneal epithelial defect trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.