Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 216 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07792239RecruitingPhase 2
Study of budiodarone for atrial fibrillation
This study tests a new medicine, budiodarone, to help control atrial fibrillation (an irregular heartbeat) in people who haven't been helped by other treatments. It may reduce the time spent in AF and improve symptoms.
GdyniaAges 18–80 - NCT07575269Recruiting
New ablation treatment for irregular heartbeat
This trial tests a new tool called FARAFLEX that uses pulsed electrical energy to treat atrial fibrillation (an irregular heart rhythm). The goal is to see if this method can safely stop AF symptoms in people whose medications haven't worked.
Jonesboro, ArkansasAges 18 years+ - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Tucson, ArizonaAges 18–80 - NCT07783984Recruiting
Comparing two procedures for persistent atrial fibrillation with enlarged left atrium
This study compares two procedures to treat persistent atrial fibrillation in people whose upper left heart chamber is enlarged: catheter ablation (a minimally invasive procedure using a tube through a vein) versus thoracoscopic ablation (a surgical approach using small chest incisions). The goal is to see which method better restores a normal heart rhythm.
Seoul, SeoulAges 19 years+ - NCT07626411RecruitingPhase 3
Blood Thinner Study for Irregular Heartbeat
This study tests a new blood thinner to prevent strokes and blood clots in people with atrial fibrillation (a common heart rhythm problem). You may qualify if you have atrial fibrillation and at least one risk factor for stroke, or if you've never taken a blood thinner before.
Dothan, AlabamaAges 18 years+ - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT07621003Recruiting
PULSed Field Ablation for New-Onset Atrial Fibrillation
This study tests a newer ablation technique using pulsed electrical energy to treat atrial fibrillation (an irregular heartbeat). You may qualify if you were recently diagnosed with AF and haven't had ablation before.
Bad OeynhausenAges 18 years+ - NCT07116525Recruiting
Study of heart mapping for abnormal rhythms
This trial tests a special catheter to map abnormal heart rhythms like ventricular tachycardia or atrial fibrillation. It may help patients who need a procedure to find and treat the source of these fast or irregular heartbeats.
BrugesAges 18 years+ - NCT07106970Recruiting
Comparing two ablation approaches for persistent atrial fibrillation
This trial tests whether adding extra ablation lines to the standard pulmonary vein isolation procedure is more effective for people with persistent atrial fibrillation that hasn't been helped by medications. The goal is to improve symptoms like palpitations, fatigue, and shortness of breath.
BeijingAges 18–80 - NCT06523738Recruiting
Studying heart size changes after shock and ablation for AF
This trial looks at how the size of your heart's upper-left chamber (left atrium) changes after a procedure to restore a normal rhythm (cardioversion). It aims to see if these changes can predict whether atrial fibrillation (AF) will come back after a later procedure called radiofrequency ablation.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT05204212Recruiting
Heart procedure to close an atrial clot risk pouch in kidney failure
This trial tests a heart procedure that closes a part of the heart called the left atrial appendage to help prevent stroke in people with an irregular heartbeat (atrial fibrillation) and very advanced kidney disease. It’s mainly for patients who can take the needed blood-thinner medicines and who do not already have a clot in that pouch.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT04240366Recruiting
Extra left atrial appendage treatment during AF ablation
This trial tests whether adding treatment to the left atrial appendage during a standard catheter ablation helps people with persistent atrial fibrillation (AF). It may improve how well AF is controlled, but you must meet specific heart rhythm and heart scan measurements to join.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT06516822Recruiting
Comparing two ablation methods for long-standing atrial fibrillation
This study tests whether adding extra scar lines (linear ablation) to the standard pulmonary vein isolation (CPVI) is better than CPVI alone for people with long-standing persistent AF that has lasted 1 to 3 years. The goal is to see which approach reduces AF better.
Beijing, Beijing MunicipalityAges 18–75 - NCT07523750Recruiting
Comparing two catheter treatments for persistent atrial fibrillation
This study compares two different catheters that use pulsed field ablation to treat a type of irregular heartbeat called persistent atrial fibrillation. The goal is to see which one works better and is safer.
Phoenix, ArizonaAges 18–80 - NCT07217067RecruitingPhase 2
Study of PKN605 for people with atrial fibrillation
This trial tests a new medicine called PKN605 for people with atrial fibrillation (irregular heartbeat). The goal is to see if it can safely help control heart rhythm. You will need to have had at least two AF episodes recently and meet other heart health criteria.
Tupelo, MississippiAges 18 years+ - NCT07734194Recruiting
Studying a new sedation combo for afib treatment
This trial tests a mild sedation method using remimazolam and fentanyl during a procedure called pulsed-field ablation for atrial fibrillation (afib). It aims to find a safe and effective way to keep you comfortable without deep sedation.
PragueAges 18 years+ - NCT07728539Recruiting
Comparing a faster ablation method for atrial fibrillation
This study compares a newer, faster type of ablation (high-power short-duration) with the standard approach for treating atrial fibrillation. The goal is to see which method is safer and more effective at restoring a normal heart rhythm.
MoscowAges 18–70 - NCT07726901Recruiting
Comparing Two Ablation Methods for Persistent Atrial Fibrillation
This study compares two techniques for treating persistent atrial fibrillation: one uses standard anatomy-based ablation, and the other uses a special mapping system to guide the procedure. It aims to find which method works better for people who have not had prior ablation.
Seoul, SeoulAges 19 years+ - NCT03397602Recruiting
Exercise program for long-term atrial fibrillation
This trial studies how an exercise training program affects people with persistent or permanent atrial fibrillation (an irregular heart rhythm). It may help improve how you feel and how well your heart and body handle activity.
London, OntarioAges 40 years+ - NCT03546374Recruiting
Stop a common heart rhythm with surgery add-on therapy
This study looks at whether an added heart device approach around the time of planned open-heart surgery can help treat non-paroxysmal atrial fibrillation (AF), a long-lasting irregular heartbeat. It may help lower ongoing AF burden in people who also need non-emergency heart surgery.
Palo Alto, CaliforniaAges 18 years+ - NCT03642509Recruiting
Compare a heart procedure to blood-thinner pills for stroke prevention
This trial studies whether closing off part of the heart (the left atrial appendage) can prevent stroke as well as long-term newer blood-thinner pills. It may help people with atrial fibrillation who recently had a stroke or a warning stroke (TIA).
Aarhus, Central JutlandAges 18 years+ - NCT04606693Recruiting
Screening for sleep apnea before heart rhythm ablation
This study looks at whether checking for sleep apnea (breathing pauses during sleep) and treating it helps people prepare for atrial fibrillation ablation. It may help by improving outcomes for patients with atrial fibrillation who keep having episodes despite medication.
Madrid, MadridAges 18 years+ - NCT04696081Recruiting
Atrial fibrillation treatment in people with active cancer
This trial studies atrial fibrillation (an irregular heartbeat) in adults who have active cancer. It looks at people whose atrial fibrillation started after their cancer diagnosis or returned after cancer diagnosis.
Caen, NormandyAges 18 years+ - NCT04715425Recruiting
Surgery vs catheter procedure for persistent atrial fibrillation
This trial compares two ways to treat persistent atrial fibrillation: a minimally invasive surgery approach versus a catheter ablation. It may help people find the most effective option to reduce ongoing abnormal heart rhythm and avoid repeat procedures.
AmsterdamAges 18–80
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Persistent Atrial Fibrillation trials by city
Studies with a site in or near these metro areas.
Persistent Atrial Fibrillation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 216 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.