Clinical trials
Post-Traumatic Stress clinical trials
Below are recruiting post-traumatic stress clinical trials, each written for real people, not researchers. We’re tracking 143 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05674617Recruiting
PTSD treatment for Veterans with serious mental illness
This trial tests a PTSD treatment approach for Veterans who also have a serious mental illness, aiming to improve day-to-day functioning. It includes Veterans who receive outpatient mental health care through the VA and have confirmed PTSD in the last month.
Baltimore, MarylandAges 18 years+ - NCT05853627RecruitingPhase 4
Propranolol versus standard therapy for trauma imagery reactions
This study tests whether propranolol (a beta-blocker) changed alongside a standard approach can reduce how strongly your body reacts during traumatic imagery. It’s meant for adults who have had a traumatic event and may help lessen fear and stress responses tied to those memories.
Charlestown, MassachusettsAges 18–65 - NCT05889741RecruitingPhase 2
Stellate nerve block plus prolonged therapy for PTSD symptoms
This Phase 2 study tests whether a procedure called a stellate ganglion block, combined with prolonged exposure therapy, can reduce PTSD symptoms in military members. It may help by targeting the body’s stress signaling while you work on trauma-related memories with guided therapy.
Fort Hood, TexasAges 18–65 - NCT05927324Recruiting
Video-based therapy coaching for mothers and young children
This trial tests a coach-guided, video feedback therapy method to help mothers and their young children. It is meant for mothers (biological) of children aged 12 to 54 months who have lived together most of the child’s life.
Lausanne, Canton of VaudAges 18–50 - NCT05934175Recruiting
Intensive therapy vs weekly trauma therapy for PTSD
This trial compares an intensive course of prolonged exposure therapy versus a standard weekly schedule for adults with post-traumatic stress disorder (PTSD). It may help you and your care team choose a treatment schedule that reduces PTSD symptoms.
StockholmAges 18 years+ - NCT06002633Recruiting
Alcohol effects and brain responses in PTSD
This study explores how people with PTSD respond to alcohol and how their brains handle approach or avoidance situations. You may participate if you drink alcohol occasionally and are between 21 and 60 years old.
Austin, TexasAges 21–60 - NCT06035809Recruiting
Smart treatment study for PTSD using brain activity feedback
This study tests a new therapy called SMART, which uses brain imaging to help regulate arousal linked to PTSD. It aims to see if combining brain feedback with therapy reduces PTSD symptoms.
London, OntarioAges 18–65 - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06088303Recruiting
Improving PTSD treatment through better communication
This study tests if improving how you talk with your doctor can make PTSD treatment work better. You can join if you have PTSD and have been on stable medications for at least 4 weeks.
Boston, MassachusettsAges 18 years+ - NCT06096740Recruiting
Talking therapy for PTSD and its effects on the brain
This study looks at how a specific type of talk therapy affects the way your brain processes rewards. You'd join a group that either starts therapy right away or waits a bit before starting. Your brain activity will be scanned with an MRI to see changes.
Austin, TexasAges 18–65 - NCT06117306RecruitingPhase 3
MDMA therapy and PTSD in veterans
This study tests if combining MDMA with therapy can help veterans with PTSD. The treatment involves taking MDMA during therapy sessions while focusing on past trauma.
San Diego, CaliforniaAges 18–64 - NCT06138522Recruiting
How Teens View Changes in PTSD Therapy
This study talks with traumatized teens and their therapists to understand how their therapy changes over time. It aims to improve care for young people with PTSD.
Paris, IDFAges 12 years+ - NCT06150196Recruiting
Brain health classes for veterans with TBI
This trial tests whether brain health and wellness classes can help veterans who have had multiple mild traumatic brain injuries and also have PTSD. The classes aim to improve cognitive symptoms like memory and attention.
Martinez, CaliforniaAges 18–75 - NCT06194851RecruitingPhase 2
Oxytocin nasal spray plus couples therapy for Veterans with PTSD
This study tests whether a nasal spray of oxytocin (a natural hormone) can boost the effects of a brief couples therapy for Veterans with PTSD. You and your partner would receive either the spray or a placebo (inactive spray) during therapy sessions to see if it helps reduce PTSD symptoms and improve relationship satisfaction.
San Diego, CaliforniaAges 18 years+ - NCT06279598Recruiting
Predicting PTSD treatment success and handling non-response (PT-STRESS)
This study looks at how well PTSD treatments work and what happens when they don't. It tests ways to predict if a treatment will be successful for you.
DeventerAges 18–65 - NCT06289621Recruiting
Brief treatment for anxiety and PTSD in South Africa
This trial tests a short, talk-based therapy for people with anxiety disorders or PTSD. It aims to help you manage symptoms in fewer sessions.
Cape TownAges 18–65 - NCT06296186Recruiting
PTSD treatment for veterans in substance use recovery
This trial tests a condensed form of prolonged exposure therapy for PTSD in veterans who are also receiving treatment for a substance use disorder. The goal is to help you process trauma and reduce substance use together.
San Diego, CaliforniaAges 18 years+ - NCT06296589Recruiting
Guilt Reduction vs. Prolonged Exposure for PTSD in Veterans
This study compares two types of talk therapy for Veterans with PTSD who also struggle with trauma-related guilt. One therapy focuses on reducing guilt, while the other is a standard trauma-focused treatment.
Little Rock, ArkansasAges 18 years+ - NCT06298279Recruiting
Online CBT for public safety personnel in Canada
This study tests an online therapy program (cognitive behavioral therapy, or CBT) designed specifically for public safety personnel. It looks at how the timing of the course and learning from others affects your progress. You can join from anywhere in Canada.
Regina, SaskatchewanAges 18 years+ - NCT06332209Recruiting
Telehealth vs. in-person therapy for trauma in Puerto Rican youth
This trial compares two ways of giving a type of therapy called Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) to children and teens in Puerto Rico who have been through a traumatic event and have post-traumatic stress symptoms. One group receives therapy in person at a clinic, and the other group receives therapy through video calls (telehealth), to see which works better.
Charleston, South CarolinaAges 7–18 - NCT06419959Recruiting
NightWare watch for better sleep and heart health in veterans with PTSD
This study tests if a special watch (NightWare) can help veterans with PTSD who have nightmares sleep better and improve heart health. The watch vibrates gently during nightmares to reduce them without waking you up.
Aurora, ColoradoAges 22–88 - NCT06469333Recruiting
Can a memory task help reduce trauma symptoms before therapy?
This study tests whether a computer-based working memory task can help reduce symptoms of trauma and stress in people who are waiting to start therapy. If you have ongoing PTSD or severe stress and haven't yet started counseling, this could be a way to get early help from home.
Vandœuvre-lès-NancyAges 18–65 - NCT06477796Recruiting
Improving sleep in veterans with TBI and sleep problems
This study tests a new way to help Veterans with both a traumatic brain injury (TBI) and sleep problems get better rest. If you are a Veteran with sleep trouble and a history of TBI, this program may help improve your sleep without needing extra medication.
Portland, OregonAges 18–89 - NCT06479447Recruiting
Patient-reported PTSD screening study
This trial is testing a simple way to check for PTSD symptoms using patient-reported questionnaires. It aims to help people who haven't been screened recently get the care they need.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for post-traumatic stress?
- Yes. Clin2 currently lists 143 recruiting post-traumatic stress studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post-traumatic stress trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post-traumatic stress trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.