Clinical trials
PrEP clinical trials
Below are recruiting prep clinical trials, each written for real people, not researchers. We’re tracking 82 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07433985Recruiting
California mobile app study for men after jail release
This study tests a mobile app to help men recently released from jail or prison who use drugs or have sex with men stay healthy and avoid HIV. It's for people who don't have HIV and live in certain California counties.
Oakland, CaliforniaAges 18–59 - NCT07370948Recruiting
Antibiotic resistance in rectal bacteria of PrEP users
This study looks at the bacteria found in the rectum of people who take PrEP. It checks if those bacteria are resistant to antibiotics.
Bologna, BolognaAges 18–45 - NCT07335289Recruiting
Same-day HIV prevention shot study
This study tests if starting a new HIV prevention shot (lenacapavir) on the same day you see a doctor and having a say in your follow-up care can help people stick with their prevention routine. It may be an option for you if you are looking for a long-acting HIV prevention method.
Boston, MassachusettsAges 18 years+ - NCT06860945Recruiting
Predicting STIs in people on HIV PrEP in Spain
This study is for people in Spain who are starting or already taking PrEP pills to prevent HIV. It aims to create a tool that can help predict who might get a sexually transmitted infection while on PrEP, so doctors can offer better monitoring or prevention.
AlmeríaAges 16 years+ - NCT06872307Recruiting
Helping Black men stay on PrEP
This study tests a new way to help Black men who have sex with men stay on PrEP (HIV prevention pills) over time. If you are at risk for HIV and have stopped taking PrEP for at least a month, you may be able to join and get support to keep taking it.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07292792Recruiting
PrEP support through peer health navigation for people leaving jail
This study tests whether adding a peer health navigator (someone with lived experience who helps with health) to regular re-entry services can help more people learn about and start PrEP, a medicine that prevents HIV.
Dallas, TexasAges 18–99 - NCT07246057Recruiting
Improving PrEP access with telehealth and community partners
This study looks at how telehealth can make PrEP (medication that helps prevent HIV) easier to get, by partnering with community organizations in Philadelphia. Researchers want to interview or survey clients and staff to understand what works and what could be improved.
Philadelphia, PennsylvaniaAges 16 years+ - NCT07213258Recruiting
HIV and meth prevention study for HIV-negative men
This study tests a smartphone program to help HIV-negative men who have sex with men reduce meth use and improve PrEP adherence. It explores whether combining support for both behaviors is more effective than addressing them separately.
San Francisco, CaliforniaAges 18–40 - NCT07216196Recruiting
Remote problem-solving for autistic teens and their caregivers
This study tests a program that helps autistic adolescents and their caregivers work together to solve problems, all from home through remote sessions. It aims to find out if this approach is practical and helpful for families.
Columbia, MissouriAges 13–21 - NCT07119359Recruiting
TB and HIV prevention study for households in Uganda
This study tests whether adding HIV prevention services to routine TB household contact checks can help more people stay healthy. If you or someone you live with has TB, you may be able to join.
KampalaAges 15 years+ - NCT07113626Recruiting
HIV testing and PrEP study for young men in Hanoi
This study tests a program to help young men who have sex with men in Hanoi get HIV testing and PrEP (medication to prevent HIV). The goal is to see if a phone-based tool can make it easier to access these services.
HanoiAges 18 years+ - NCT05762705Recruiting
Mobile game app to help you take PrEP
This trial tests whether a mobile gaming app can help people stick with PrEP (HIV prevention) so doses aren’t missed. It may help you stay on track during the first month after starting or restarting PrEP.
Boston, MassachusettsAges 15–34 - NCT07049029Recruiting
Physical activity and pain resilience study for teens
This study tests if physical activity can help teenagers with chronic pain feel better and be more active. It may help you learn ways to manage pain.
Columbus, OhioAges 12–17 - NCT07011563Recruiting
Helping teens & adults talk about sexual health
This study helps teens and their trusted adults have open conversations about sexual health. It's for young people ages 14 to 17 who have had oral or anal sex with another male.
Providence, Rhode IslandAges 14–17 - NCT06964373Recruiting
Cervical ripening balloons for same-day abortion preparation
This study tests using a small balloon to prepare the cervix for a same-day abortion procedure between 18 and almost 20 weeks of pregnancy. It may help people who want the procedure done without needing to stay overnight.
Albuquerque, New MexicoAges 18 years+ - NCT06930508Recruiting
Bringing HIV prevention meds to a family planning clinic
This study looks at offering HIV prevention medicines (PrEP) to patients visiting a family planning clinic. It aims to make it easier for people to access this care alongside their regular visit.
Providence, Rhode IslandAges 16 years+ - NCT06880224Recruiting
HIV prevention and treatment for Nigerian youth aged 15-24
This study tests better ways to find and treat HIV in young people (ages 15-24) in Nigeria. It offers either HIV prevention medicine (PrEP) if you are HIV-negative, or HIV treatment if you are newly diagnosed with HIV.
Uyo, Akwa Ibom StateAges 15–24 - NCT04331704RecruitingPhase 4
Alcohol and sexual health program for men at risk of HIV
This study tests an alcohol- and sexual-health program to help reduce HIV risk in men who recently had condomless sex and drink heavily. It may help you by offering structured support around drinking and HIV prevention (PrEP).
Gainesville, FloridaAges 18–30 - NCT06785376Recruiting
HIV testing and prevention program for Black men
This trial tests a program to help Black men in NYC who have sex with men access HIV testing and prevention pills. Your participation could help make HIV prevention easier to get for you and your community.
New York, New YorkAges 18–65 - NCT06741618Recruiting
HIV prevention study for young men
This study tests a mobile app to help young men who have sex with men stay HIV-negative. It focuses on people who have had condomless anal sex recently and are not using PrEP.
New York, New YorkAges 16–25 - NCT06703060Recruiting
A trauma-informed approach to help Black women start PrEP
This study tests a program that helps Black women start PrEP (a daily pill to prevent HIV). It focuses on understanding and addressing past trauma to make it easier to take PrEP, and is designed for women who have not used PrEP before.
Baltimore, MarylandAges 18 years+ - NCT06637436Recruiting
PrEP motivation help for men who use meth
This study tests two ways to help men who were assigned male at birth and use methamphetamine stay motivated to start PrEP, a medicine that prevents HIV. You may join if you are HIV-negative or don't know your status and haven't taken PrEP recently.
Miami, FloridaAges 18 years+ - NCT06576648Recruiting
HIV prevention study for young transgender women in Thailand
This study aims to reduce HIV stigma and improve PrEP use among young transgender women in Thailand. It is testing a new program to help those who are not already taking PrEP consistently.
BangkokAges 18–29 - NCT06526507Enrolling by invitationPhase 4
PrEP study for pregnant women in Kenya
This study aims to expand access to PrEP (a daily pill that prevents HIV) for pregnant and postpartum women visiting maternal and child health clinics in Kenya. It also includes health care workers who provide PrEP services.
Kapsabet, NandiAges 15–50
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Common questions
- Are there clinical trials for prep?
- Yes. Clin2 currently lists 82 recruiting prep studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prep trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prep trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.