Clinical trials
PrEP clinical trials
Below are recruiting prep clinical trials, each written for real people, not researchers. We’re tracking 79 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06576648Recruiting
HIV prevention study for young transgender women in Thailand
This study aims to reduce HIV stigma and improve PrEP use among young transgender women in Thailand. It is testing a new program to help those who are not already taking PrEP consistently.
BangkokAges 18–29 - NCT06872307Recruiting
Helping Black men stay on PrEP
This study tests a new way to help Black men who have sex with men stay on PrEP (HIV prevention pills) over time. If you are at risk for HIV and have stopped taking PrEP for at least a month, you may be able to join and get support to keep taking it.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06703060Recruiting
A trauma-informed approach to help Black women start PrEP
This study tests a program that helps Black women start PrEP (a daily pill to prevent HIV). It focuses on understanding and addressing past trauma to make it easier to take PrEP, and is designed for women who have not used PrEP before.
Baltimore, MarylandAges 18 years+ - NCT06668363Recruiting
HIV prevention and alcohol reduction for STI clinic patients
This study tests a program to help people receiving STI care reduce heavy drinking and prevent HIV. It may be a good fit if you drink heavily and want support with HIV prevention or treatment adherence.
LilongweAges 18 years+ - NCT06506188Recruiting
Improving HIV prevention for breastfeeding women in Malawi
This study looks at how to make it easier for women in Malawi to stay on PrEP after giving birth while breastfeeding. Researchers will check medical records and ask some women to do a short survey and a finger stick blood test.
LilongweAges 15–99 - NCT07011563Recruiting
Helping teens & adults talk about sexual health
This study helps teens and their trusted adults have open conversations about sexual health. It's for young people ages 14 to 17 who have had oral or anal sex with another male.
Providence, Rhode IslandAges 14–17 - NCT06637436Recruiting
PrEP motivation help for men who use meth
This study tests two ways to help men who were assigned male at birth and use methamphetamine stay motivated to start PrEP, a medicine that prevents HIV. You may join if you are HIV-negative or don't know your status and haven't taken PrEP recently.
Miami, FloridaAges 18 years+ - NCT04331704RecruitingPhase 4
Alcohol and sexual health program for men at risk of HIV
This study tests an alcohol- and sexual-health program to help reduce HIV risk in men who recently had condomless sex and drink heavily. It may help you by offering structured support around drinking and HIV prevention (PrEP).
Gainesville, FloridaAges 18–30 - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT05148494RecruitingPhase 4
Enema versus drink for bowel prep before rectal surgery
This trial compares two bowel-clearing methods—an enema given through the rectum versus an oral (by mouth) mechanical bowel prep—during a specific type of rectal surgery. It aims to find which method works better and is easier or safer for patients.
Halifax, Nova ScotiaAges 18–75 - NCT05624931Recruiting
Helping pregnant women stay on PrEP after starting it
This study tries to reduce the psychological barriers that make it hard for pregnant or postpartum women to keep taking PrEP. It may help by offering support tailored to stress, trauma symptoms, or depression—especially soon after PrEP is started.
Boston, MassachusettsAges 15 years+ - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+ - NCT05762705Recruiting
Mobile game app to help you take PrEP
This trial tests whether a mobile gaming app can help people stick with PrEP (HIV prevention) so doses aren’t missed. It may help you stay on track during the first month after starting or restarting PrEP.
Boston, MassachusettsAges 15–34 - NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+ - NCT05774548Recruiting
Study of PrEP use and its cost in HIV prevention
This study looks at how taking PrEP (medicine to prevent HIV) affects HIV prevention and how much it costs in real life. You may be able to join if you are HIV-negative and are interested in starting, currently using, or have used PrEP before.
Bangkok, BangkapiAges 18 years+ - NCT05813964RecruitingPhase 3
Event-based HIV prevention pill in MSM in Thailand and France
This Phase 3 trial tests how well and how safely an HIV prevention pill (TAF/FTC) works when it’s taken around sexual events. It aims to find a prevention option that’s effective and acceptable for men who have sex with men at higher risk of HIV.
ParisAges 18 years+ - NCT06005298Recruiting
Testing SBIRT to help with PrEP and alcohol use
This study looks at whether talking about alcohol use can help people stick with their PrEP routine. It tests a simple program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) to support your health and HIV prevention.
Louisville, KentuckyAges 18–85 - NCT06072443Recruiting
Study to help people stick with their PrEP
This study tests ways to help people stick with their PrEP (the medicine that prevents HIV). If you're getting PrEP through West Virginia Health Right and have a smartphone, you may be able to join.
Charleston, West VirginiaAges 18 years+ - NCT06226155Recruiting
HIV prevention support for pregnant women in Zimbabwe
This study in Zimbabwe tests a program to help pregnant women start and stay on PrEP (medication that prevents HIV). It aims to make PrEP easier to use during pregnancy for women who are at risk of HIV.
HarareAges 15–55 - NCT05234125Recruiting
Lifestyle counseling during pregnancy for African American women
This trial tests a better lifestyle counseling program during pregnancy to help improve health—especially for women who started pregnancy at a higher weight. It may help you learn practical changes for a healthier pregnancy and outcomes.
Chicago, IllinoisAges 18–40 - NCT06741618Recruiting
HIV prevention study for young men
This study tests a mobile app to help young men who have sex with men stay HIV-negative. It focuses on people who have had condomless anal sex recently and are not using PrEP.
New York, New YorkAges 16–25 - NCT06860945Recruiting
Predicting STIs in people on HIV PrEP in Spain
This study is for people in Spain who are starting or already taking PrEP pills to prevent HIV. It aims to create a tool that can help predict who might get a sexually transmitted infection while on PrEP, so doctors can offer better monitoring or prevention.
AlmeríaAges 16 years+ - NCT07049029Recruiting
Physical activity and pain resilience study for teens
This study tests if physical activity can help teenagers with chronic pain feel better and be more active. It may help you learn ways to manage pain.
Columbus, OhioAges 12–17 - NCT07113626Recruiting
HIV testing and PrEP study for young men in Hanoi
This study tests a program to help young men who have sex with men in Hanoi get HIV testing and PrEP (medication to prevent HIV). The goal is to see if a phone-based tool can make it easier to access these services.
HanoiAges 18 years+
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Common questions
- Are there clinical trials for prep?
- Yes. Clin2 currently lists 79 recruiting prep studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prep trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prep trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.