Clinical trials
Progression clinical trials
Below are recruiting progression clinical trials, each written for real people, not researchers. We’re tracking 725 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219680Recruiting
Communication quality of life in primary progressive aphasia
This trial tests a therapy to improve communication for people with primary progressive aphasia (PPA), a condition that slowly affects language. You and a care partner will attend video sessions to work on communication goals together.
Austin, TexasAges 40 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT07260253Recruiting
Remote brain stimulation for language in primary progressive aphasia
This study tests if a non-invasive brain stimulation technique called tDCS, done at home with remote supervision, can help improve language skills in people with the logopenic variant of primary progressive aphasia (PPA).
San Francisco, CaliforniaAges 40 years+ - NCT06593951Recruiting
EPM1 natural history study
This study will follow people with EPM1 over time to better understand the disease. It is a registry, meaning you will share information through video calls and questionnaires, with no experimental treatments involved.
Boston, MassachusettsAges Any age - NCT07477639RecruitingPhase 1/Phase 2
Testing TRX319 for worsening multiple sclerosis
This trial tests a new treatment called TRX319 for people with progressive multiple sclerosis (MS) that has been getting worse. The study wants to see if this treatment can help slow down disability progression.
Kansas City, KansasAges 18–65 - NCT06649084Enrolling by invitation
Language treatment study for primary progressive aphasia
This study tests a multi-component language treatment for people with primary progressive aphasia (a type of dementia that first affects language). It aims to help improve communication skills with support from a study partner.
Austin, TexasAges Any age - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Birmingham, AlabamaAges 18 years+ - NCT05386394RecruitingPhase 2
Brain stimulation to help primary progressive aphasia speech
This trial tests a non-painful brain stimulation method to improve language and speech problems caused by primary progressive aphasia. It may help some people communicate more clearly by targeting specific brain regions.
Baltimore, MarylandAges 50–90 - NCT06511752RecruitingEarly Phase 1
Support group for Spanish/English speakers with progressive aphasia
This trial tests a support group program for people with progressive aphasia (a language disorder that gets worse over time) and their caregivers. The groups meet online to share experiences and learn together.
Austin, TexasAges 18 years+ - NCT06647641Recruiting
Genetics study for PSP, CBS, MSA, and related conditions
This study looks at genetic factors in people with PSP, CBS, MSA, or similar brain conditions, and also in their family members. It involves genetic testing to learn more about these diseases and may help find new treatments.
Boston, MassachusettsAges 35 years+ - NCT07301268RecruitingPhase 2
GI-102 with or without pembrolizumab before brain surgery
This trial is testing a new drug called GI-102, given alone or with pembrolizumab, before surgery for a type of brain tumor called glioblastoma or grade 4 astrocytoma. The goal is to see if these drugs can help shrink the tumor before it's removed.
Rochester, MinnesotaAges 18 years+ - NCT05139719RecruitingPhase 2
HEC585 trial for slowing lung scarring decline
This Phase 2 study tests whether HEC585 can slow the decline in lung function in people with progressive fibrosing interstitial lung disease (PF-ILD). It may help preserve breathing capacity and breathing tolerance over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03313011Recruiting
Study brain patterns in progressive apraxia of speech
This study looks at brain changes in two types of progressive apraxia of speech, a condition that slowly worsens speech clarity. It may help researchers better understand the brain basis of your speech symptoms and how these types differ.
Rochester, MinnesotaAges 18 years+ - NCT07698977Recruiting
Slowing nearsightedness with special glasses
This study tests special glasses to slow down nearsightedness (myopia) getting worse in children. Researchers want to see if these glasses help keep eyes from getting more nearsighted over time.
BudapestAges 6–15 - NCT06138132RecruitingPhase 1
CAR-T cell therapy for progressive multiple sclerosis
This trial is testing a type of immunotherapy called CAR-T cells (made from your own immune cells) to see if it can help slow or stop progressive multiple sclerosis. It is a very early safety study, so only people with progressive MS who meet strict health criteria can join.
Palo Alto, CaliforniaAges 18–65 - NCT06726239Recruiting
Relaxation exercises before getting up after heart bypass
This study tests whether doing gentle relaxation exercises before getting out of bed can help reduce pain, anxiety, and stress after heart bypass surgery. It may make recovery more comfortable.
Istanbul, IstanbulAges 35–65 - NCT07089537Recruiting
Muscle relaxation and brain waves
This study tests how a simple muscle relaxation technique affects brain wave activity in healthy adults. It might help you understand your own relaxation response.
Kaohsiung CityAges 18 years+ - NCT07317271Recruiting
Virtual reality for burn symptoms
This trial tests a virtual reality program to help with symptoms like pain, trouble sleeping, and itching after a burn injury. You can join from home using your own device.
Baltimore, MarylandAges 18 years+ - NCT07355387Recruiting
Home-based balance training for multiple sclerosis
This study tests a 12-week home-based balance training program for people with multiple sclerosis. Sessions are done online with a helper present, and the goal is to improve walking and reduce fall risk.
Chicago, IllinoisAges 40–90 - NCT01818661RecruitingPhase 4
Imaging study for progressive apraxia of speech
This trial uses repeated brain scans to study how progressive apraxia of speech changes over time. It may help doctors better understand the condition and improve future tracking and care.
Rochester, MinnesotaAges 18 years+ - NCT06675864RecruitingPhase 1/Phase 2
YTB323 for non-active progressive MS
This trial tests a new treatment called YTB323, which is a type of personalized cell therapy (CAR-T) designed to target your immune system and slow down MS progression. It is for people with non-active progressive MS who have seen their disability worsen recently.
Darlinghurst, New South WalesAges 18–60 - NCT07457502Recruiting
Home environment and lung disease progression study
This study looks at whether things in your home might affect how quickly your lung disease gets worse. You and a matched group will be followed to see how your home environment impacts your lung health.
Paris, ParisAges 18 years+ - NCT07619209Recruiting
Relaxation exercises for cancer patients with breathing difficulty
This study tests whether gentle muscle relaxation and deep breathing exercises help cancer patients in palliative care feel less breathless, less tired, and better able to care for themselves. You would learn and practice these exercises and answer questions about how you feel.
Ankara, YENIMAHALLEAges 18 years+ - NCT07067463RecruitingPhase 3
Testing orelabrutinib for primary progressive MS
This trial tests a daily pill called orelabrutinib to see if it can slow disability progression in people with primary progressive multiple sclerosis (PPMS). It may be an option for patients whose symptoms have been getting worse over the past two years.
Pheonix, ArizonaAges 18–60
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Common questions
- Are there clinical trials for progression?
- Yes. Clin2 currently lists 725 recruiting progression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a progression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a progression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.