Clinical trials
Progression clinical trials
Below are recruiting progression clinical trials, each written for real people, not researchers. We’re tracking 716 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07139743RecruitingPhase 1
CAR T-cell therapy for progressive multiple sclerosis
This study tests a new treatment using a patient's own immune cells, modified to fight the immune system's attack on the nervous system. It aims to slow or stop the progression of multiple sclerosis when standard treatments have not worked.
Palo Alto, CaliforniaAges 18–60 - NCT07875686RecruitingPhase 2
Comparing two muscle-cutting methods for achalasia treatment
This study compares two ways of doing a surgery called POEM to treat achalasia, a condition where the esophagus doesn't empty properly. The surgery cuts the muscle at the lower end of the esophagus to help food pass more easily. The trial will see if cutting the muscle partially works as well as cutting it all the way through.
CairoAges 18–90 - NCT07298824RecruitingPhase 2
MR-61 eye drops for slowing nearsightedness in children
This trial tests an eye drop called MR-61 to see if it can slow down worsening nearsightedness (myopia) in children and teens. The study aims to find a safe and easy way to keep their vision from getting worse.
Nanchang, JiangxiAges 3–18 - NCT07498426RecruitingPhase 3
Study of NIO752 for progressive supranuclear palsy
This trial tests a new medicine called NIO752 for people with progressive supranuclear palsy (PSP), a condition that affects movement, balance, and thinking. The goal is to see if it can help slow the disease's progression.
Scottsdale, ArizonaAges 41–81 - NCT04772768Recruiting
Checking problems in vein bypass grafts in people with recurring chest pain
This study looks at how vein bypass grafts are working over time in people who had heart bypass surgery and now have recurring angina (chest discomfort). It may help doctors better understand why symptoms come back and how the heart and grafts change.
AmsterdamAges 18–90 - NCT05961644RecruitingPhase 2/Phase 3
Cladribine vs placebo for non-active progressive multiple sclerosis
This trial tests whether cladribine (vs an inactive placebo pill) can slow disability worsening in people with a non-active, progressive form of multiple sclerosis. It may help by reducing the immune activity that can drive ongoing nerve damage, even without recent relapses.
Warsaw, Masovian VoivodeshipAges 30–65 - NCT05740722RecruitingPhase 2
Nicotinamide riboside for progressive multiple sclerosis
This Phase 2 trial studies whether a vitamin-like supplement called nicotinamide riboside can slow or improve disability in progressive multiple sclerosis. It may help people whose symptoms have been steadily getting worse over the last 2 years.
BergenAges 18–65 - NCT07863180RecruitingPhase 1/Phase 2
Tributyrin for progressive supranuclear palsy
This trial tests a supplement called tributyrin to see if it can help people with progressive supranuclear palsy (PSP), a condition that affects movement and balance. The study is done virtually, so you can participate from home with a caregiver's help.
Ann Arbor, MichiganAges 45 years+ - NCT05204459Recruiting
MRI and eye-scan study for MS and related conditions
This trial uses brain MRI and eye imaging tests to study research markers in people with multiple sclerosis (MS) and related neurologic conditions. It may help researchers better understand these diseases and how they change over time.
Los Angeles, CaliforniaAges 18 years+ - NCT07842133Recruiting
Relaxation exercises for fatigue and breathing in scleroderma
This study tests whether progressive muscle relaxation exercises can help reduce fatigue and shortness of breath while improving lung function in people with scleroderma. Participants will learn and practice these exercises as part of the study.
Gaziantep, ŞehitkamilAges 18–65 - NCT07798700Recruiting
Biofluid research for brain and movement disorders
This study collects blood, spinal fluid, and other samples from people with brain or movement disorders, their family members, and healthy volunteers. The goal is to find better ways to diagnose and understand these conditions.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07764250Recruiting
Comparing two balance training approaches for older adults with mild to moderate memory or thinking problems
This study compares two types of balance training (one where you stand still and one where you stand while doing a task) for older adults with mild to moderate thinking or memory problems. It aims to see which training is better for improving balance and daily function.
Islamabad, CapitalAges 55 years+ - NCT07752992Recruiting
Support for caregivers who fear cancer returning
This study tests a short online program to help caregivers of people with advanced cancer manage intense worry about the cancer coming back or getting worse. The program is delivered over video and aims to reduce fear and worry.
AarhusAges 18 years+ - NCT07744022Recruiting
Exercise comparison for children with obesity
This study compares two types of exercise programs — progressive neuromuscular stabilization exercises versus aerobic exercises — to see which one better improves body composition and balance in children with obesity. It aims to find a fun, effective way to help kids move better and feel healthier.
IstanbulAges 12–18 - NCT07732907Recruiting
Study of PML risk in MS patients taking Zeposia
This study looks at people with multiple sclerosis who have taken Zeposia (ozanimod) and later developed a rare brain infection called PML. The goal is to understand how often this happens and to confirm cases.
Lawrenceville, New JerseyAges Any age - NCT07726030Recruiting
Exercises for chronic rotator cuff pain in overhead athletes
This trial compares two types of exercises to see which better reduces chronic shoulder pain in male athletes who play overhead sports. If you have ongoing rotator cuff tendinopathy and are an active overhead athlete, this study may help find the best exercise approach for you.
Faisalābad, Punjab ProvinceAges 17–35 - NCT05811013Recruiting
Static magnetic brain stimulation for progressive multiple sclerosis
This trial studies whether a noninvasive brain stimulation approach using a static magnetic field can help people with progressive multiple sclerosis. It aims to improve progressive nerve function while keeping other treatments stable.
Pozzilli, IserniaAges 18–65 - NCT07683728Recruiting
Observational study of progressive pulmonary fibrosis (PPF) in China
This study is a registry that collects information from people in China who have progressive pulmonary fibrosis (PPF), a lung condition that gets worse over time. It aims to better understand the disease and help doctors improve care.
BeijingAges Any age - NCT06473714Recruiting
Brain stimulation for language in progressive aphasia
This trial tests a gentle, non-invasive brain stimulation called tDCS to see if it can help improve language control in people with primary progressive aphasia. It is done in a hospital in Nice, France.
NiceAges 18 years+ - NCT07647276Recruiting
Massage and relaxation for period pain relief
This study tests whether connective tissue massage (a hands-on technique) and progressive relaxation exercises can reduce severe menstrual cramps. If you have primary dysmenorrhea—painful periods without an underlying medical cause—this trial may help you find natural pain relief.
DenizliAges 18–30 - NCT07653841Recruiting
Balance vs. strength training for knee osteoarthritis
This study compares two types of exercise programs (a balance-focused training and a progressive strengthening program) added to usual physical therapy. The goal is to see which works better for reducing knee pain and improving daily function in people with knee osteoarthritis.
Islamabad, ICTAges 40–70 - NCT05253326Recruiting
Relaxing muscle exercises after spine surgery
This trial tests whether a structured “progressive muscle relaxation” routine can reduce pain and help recovery after spine surgery. You may be asked to learn and practice the relaxation steps even if you’ve never done them before.
Istanbul, ÜsküdarAges 18 years+ - NCT07630623Enrolling by invitation
Relaxation and grip exercises for pregnant women with preeclampsia
This study tests whether two simple exercises—progressive muscle relaxation (tensing and releasing muscle groups) and finger grip exercises—can help pregnant women with preeclampsia manage stress, anxiety, fatigue, and sleep problems. Preeclampsia is high blood pressure during pregnancy that needs careful monitoring.
Ordu, AltinorduAges 18 years+ - NCT04920318Recruiting
Study to improve language in primary progressive aphasia
This trial looks at ways to improve language abilities in people with primary progressive aphasia (a long-term brain condition that affects speech and language). It may help if your communication problems come from this condition and you can safely take part in the study activities, which likely involve language practice and MRI scanning.
Tucson, ArizonaAges 45–80
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Common questions
- Are there clinical trials for progression?
- Yes. Clin2 currently lists 716 recruiting progression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a progression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a progression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.