Clinical trials · California
Psychosis clinical trials in California
We’re tracking 21 recruiting psychosis studies with a site in California — including Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06640803Recruiting
Early psychosis risk stepped-care program
This study offers a step-by-step care program for teens and young adults at high risk for psychosis. It aims to provide the right level of support early on to prevent or reduce the severity of symptoms.
Sacramento, CaliforniaAges 12–25 - NCT04373317RecruitingPhase 4
Comparing two medicines for hallucinations in Parkinson's disease
This study compares two drugs, pimavanserin and quetiapine, to see which works better for hallucinations or delusions caused by Parkinson's disease. The goal is to help patients manage these symptoms more effectively.
Loma Linda, CaliforniaAges 40 years+ - NCT05511363RecruitingPhase 3
Study of a new medicine for psychosis in Alzheimer's disease
This trial tests a new drug called KarXT to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. If you or a loved one has Alzheimer's and experiences these symptoms, this study might offer a new treatment option.
Encino, CaliforniaAges 55–90 - NCT07459660Enrolling by invitationPhase 2
Long-term study of ML-007C-MA for Alzheimer's psychosis
This trial tests a long-term treatment (ML-007C-MA) for people with Alzheimer's disease who have psychosis. It is for those who already completed an earlier study with the same drug and may benefit from continuing it. The goal is to see if ongoing treatment is helpful and safe.
Anaheim, CaliforniaAges 55–91 - NCT07095465Enrolling by invitationPhase 3
Long-term study of ACP-204 for psychosis in Lewy body dementia
This study tests a medication called ACP-204 for psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a long-term extension open to patients who completed a previous ACP-204 study, to see if the drug continues to be helpful and safe.
Irvine, CaliforniaAges 55–84 - NCT05980949RecruitingPhase 3
Long-term safety study of KarXT for Alzheimer's psychosis
This trial tests the long-term safety of an investigational drug called KarXT for people with psychosis caused by Alzheimer's disease. It is for those who have already completed a previous KarXT study and want to continue treatment.
Encino, CaliforniaAges 55–90 - NCT06126224RecruitingPhase 3
Testing KarXT for Alzheimer's-related psychosis
This clinical trial tests an investigational oral medication called KarXT for treating psychosis (hallucinations or delusions) in people with Alzheimer's disease. The study aims to see if the drug can safely reduce these symptoms.
Anaheim, CaliforniaAges 55–90 - NCT07029581RecruitingPhase 2
Testing ACP-204 for psychosis in Lewy body dementia
This trial tests a new drug called ACP-204 for people with dementia from Lewy body disease or Parkinson's who also have hallucinations or delusions. The goal is to see if the drug can safely reduce these symptoms without worsening thinking problems.
Irvine, CaliforniaAges 55–84 - NCT06540833RecruitingPhase 2
Study of ITI-1284 for psychosis in Alzheimer's disease
This trial tests an experimental drug, ITI-1284, to see if it can safely reduce psychosis (hallucinations or delusions) in people with Alzheimer's disease. It may be an option for patients who have both Alzheimer's and related psychotic symptoms.
Anaheim, CaliforniaAges 55 years+ - NCT07226895RecruitingPhase 1/Phase 2
Study of MT1988 for people at high risk for psychosis
This trial tests a new drug called MT1988 in people who show early warning signs of psychosis. Researchers want to see if it changes certain markers in the body related to mental health.
Los Angeles, CaliforniaAges 17–30 - NCT06887192RecruitingPhase 2
Testing ML-007C-MA for Alzheimer's Psychosis
This trial tests a study drug called ML-007C-MA to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease who also have psychosis. If you or your loved one has Alzheimer's and has been experiencing false beliefs or seeing/hearing things that aren't there for at least two months, this study may be an option.
Anaheim, CaliforniaAges 55–90 - NCT06159673RecruitingPhase 2/Phase 3
ACP-204 for Alzheimer's with psychosis
This study tests a new medicine called ACP-204 for people with Alzheimer's disease who also have psychosis (like seeing or hearing things that aren't real). It aims to see if the drug can help reduce these symptoms safely.
Anaheim, CaliforniaAges 55–95 - NCT04411225RecruitingPhase 3
CBD may help early psychosis along with usual treatment
This Phase 3 trial tests whether taking cannabidiol (CBD) can reduce symptoms when added to standard care for early psychosis (like first-episode psychosis or attenuated psychosis). It may help some people have fewer troubling thoughts or perceptions over time.
La Jolla, CaliforniaAges 16–30 - NCT05457140Recruiting
Testing genes and other samples in youth with first psychosis
This study looks at many types of tests (including genetic testing and other lab data) to help understand what may be causing first-time psychosis symptoms in youth. It may help doctors learn more about the condition for future care, and it can involve analyzing family genetic information.
San Diego, CaliforniaAges 7–17 - NCT06947941RecruitingPhase 3
Testing karxt for psychosis in alzheimer's disease
This study tests whether a new medicine called KarXT can help with psychosis (hallucinations or delusions) in people with Alzheimer's disease. It aims to reduce troubling symptoms while being safe for older adults.
Chino, CaliforniaAges 55–90 - NCT06194799Enrolling by invitationPhase 3
Long-term ACP-204 for Alzheimer's psychosis
This study tests a long-term medicine (ACP-204) for people with Alzheimer's disease who also have psychosis (hallucinations or delusions). If you took part in the earlier ACP-204 study, this open-label extension lets you continue receiving the medicine to see how well it works over time.
Costa Mesa, CaliforniaAges 55–95 - NCT04007510Enrolling by invitation
Early psychosis study for patients, families, and care teams
This study looks at how to improve early psychosis care using data-driven planning and support for people who are newly developing symptoms. It may help by sharing better ways to coordinate treatment among patients, families, and the clinic/community teams.
Sacramento, CaliforniaAges 8–40 - NCT05185128Recruiting
Social skills training and brain imaging in teens with autism
This study looks at how social thinking and social skills training affect the brain in teens with autism, compared with teens with other severe mental health conditions and typically developing teens. It may help researchers understand what drives social difficulties and what could improve social functioning.
Loma Linda, CaliforniaAges 12–18 - NCT05617898Recruiting
Study how social rewards work in early schizophrenia
This study looks at how your brain learns from positive social experiences in people who are in the early stages of schizophrenia-type illness. It may help researchers understand “social anhedonia” (feeling less pleasure or reward from social situations) and guide future treatments.
Los Angeles, CaliforniaAges 18–35 - NCT06586164Recruiting
Rehabilitation research for veterans with serious mental illness
This study is testing a new rehabilitation program for veterans with serious mental illness, like schizophrenia, bipolar disorder, or PTSD. If you join, you will help researchers see if this program improves daily functioning and quality of life.
San Diego, CaliforniaAges 18–83 - NCT06585787RecruitingPhase 3
Testing KarXT for psychosis in Alzheimer’s disease
This study tests an investigational medication (KarXT) for treating psychosis—hallucinations or delusions—in people with Alzheimer’s disease. It aims to see if the drug can reduce these symptoms safely and effectively.
Anaheim, CaliforniaAges 55–90
Psychosis trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting psychosis studies listed above.
- Advanced Research Center (ARC), Inc. · 4 studies
- ATP Clinical Research · 4 studies
- Local Institution · 3 studies
- Sunwise Clinical Research · 3 studies
- ATP Clinical Research Inc. · 2 studies
- Clinical Site · 2 studies
- Inland Psychiatric Medical Group · 2 studies
- Local Institution - 1033 · 2 studies
What taking part in a psychosis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Psychosis trials in other states
Common questions
- Are there psychosis clinical trials in California?
- Yes. We're currently tracking 21 recruiting psychosis studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a psychosis study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a psychosis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New psychosis studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.