Clinical trials
Root Canal Treatment clinical trials
Below are recruiting root canal treatment clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06146894Recruiting
Comparing filling methods for tooth pain after root canal
This study compares different ways to fill a tooth's root canals after cleaning them. It looks at which method causes the least pain after a single visit root canal treatment.
Kafr ash Shaykh, Kafr El-ShaikhAges 18–60 - NCT06528574Recruiting
Pain after root canal cleaning methods
This trial compares two methods of cleaning a tooth's root canal to see which causes less pain after the procedure. It is for people with a specific type of tooth nerve pain (acute pulpitis) in a lower back molar.
Cleveland, OhioAges 18–50 - NCT07340606Recruiting
AI predictions for root canal success in painful molars
This study tests whether an AI tool can help predict if a simpler root canal treatment (pulpotomy) will work for back teeth with adult, painful pulp infections. If successful, it may help avoid more complex procedures.
CairoAges 20–45 - NCT07549373Recruiting
Laser and natural treatments for tooth root infections in diabetics
This study tests whether diode laser (a type of focused light), gudmar (an herbal supplement), and vinegar can help treat tooth infections during root canal therapy in people with type 2 diabetes. The goal is to see if these treatments reduce infection and improve healing.
Noida, Uttar PradeshAges 25–60 - NCT06934317Enrolling by invitation
Bite force after root canal treatment vs. regenerative therapy
This trial compares how strongly you can bite down on a tooth that has had a root canal or a newer regenerative treatment. It is for people with a dead nerve inside a permanent tooth who are otherwise healthy.
IrbidAges 10–60 - NCT04527705Recruiting
Testing endodontic retreatment in one versus two visits
This study compares doing tooth root-canal retreatment in one visit versus two visits. It’s meant to see which approach leads to better outcomes for teeth with infection at the root tip (apical periodontitis).
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT07077694Enrolling by invitation
AI study to find missed root canals in treated lower back teeth
This study uses artificial intelligence and 3D dental imaging to check if any root canals were missed during previous root canal treatment on lower back teeth. It may help find hidden problems and guide better treatment.
Cairo, Cairo GovernorateAges 18–50 - NCT07048028Recruiting
Chitosan rinse for root canals in premolars
This study tests a new natural mouth rinse (chitosan) during root canal treatment for lower premolar teeth. Researchers want to see if it helps clean the tooth better than standard treatment.
Ordu, AltınorduAges 18 years+ - NCT06959602Enrolling by invitation
Comparing two root canal cleaning methods for infected teeth
This trial compares two ways of cleaning infected root canals during a root canal procedure. The goal is to see which method better removes bacteria and improves healing.
AthensAges 18–80 - NCT05841290Recruiting
Compare types of dental sealers for post-procedure pain
This study checks how much pain happens after dental procedures using different types of filling/sealing materials. It may help you and future patients understand which sealer options tend to cause less postoperative discomfort.
El Shorouk, Cairo GovernorateAges 18–50 - NCT06453304RecruitingPhase 2/Phase 3
Licorice root gel for root canal infection
This trial tests a natural anti-inflammatory medicine called glycyrrhizin (from licorice root) used inside the tooth during root canal treatment. It aims to see if it helps kill bacteria and reduce infection better than standard medications.
Al MansurahAges 20–60 - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT07388901Recruiting
Comparing two root canal sealers for infection treatment
This trial compares two materials (iRoot SP and nRoot SP) used to fill root canals after infection. It aims to see which works better for healing apical periodontitis, an infection around the tooth root.
Hangzhou, ZhejiangAges 18 years+ - NCT07410780Recruiting
Pain after root canal with two different sealers
This trial compares two types of root canal filling materials—bioceramic and calcium hydroxide—to see which one causes less pain after the procedure. If you have a tooth with a live but inflamed nerve, you may be able to join.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT05763420Enrolling by invitation
Testing a bioceramic root-canal sealer in adult molar teeth
This trial tests how well a bioceramic sealer works for primary (first-time) root canal treatment in permanent back teeth. It may help by improving the chances that the treated tooth heals and stays functional.
Janūb as Surrah, Hawalli GovernateAges 18–65 - NCT06466538RecruitingPhase 2/Phase 3
Boswellia vs standard medicine for root canal infection
This trial tests whether a natural gum resin (Boswellia) placed inside the tooth during root canal treatment can fight infection better than standard medications. It may be a good option for people with a single-rooted tooth infection who are otherwise healthy.
Al MansurahAges 20–60 - NCT07439614Recruiting
Comparing two ways to clean a dead nerve during a root canal
This trial compares two different ways to clean a molar tooth during a root canal when the nerve is dead. The goal is to find which method is better at removing infection without causing discomfort.
Buffalo, New YorkAges 18–70 - NCT07453576Recruiting
Comparing bleach strengths for root canal retreatment pain
This trial tests if different concentrations of sodium hypochlorite (a disinfectant used in root canals) affect pain and certain natural chemicals in the tooth during root canal retreatment. It may help find the best option to reduce discomfort.
Erzurum, ErzurumAges 18–65 - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07273552Recruiting
Root control in 3D-printed clear aligners
This study tests a new type of 3D-printed clear aligner and how well it can control the way teeth roots move. It may be a good option if you have gaps in your teeth (not crowding) and do not need any tooth extractions.
Banī SuwayfAges 18–45
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Common questions
- Are there clinical trials for root canal treatment?
- Yes. Clin2 currently lists 44 recruiting root canal treatment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a root canal treatment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a root canal treatment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.