Clinical trials
Root Canal Treatment clinical trials
Below are recruiting root canal treatment clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07059481Recruiting
Root canal sealers and oxidative stress study
This study is looking at how different types of root canal filling materials (sealers) affect oxidative stress markers in the body. It is for people with a single tooth that has a chronic infection at the root tip and needs a root canal.
Ordu, Ordu- AltınorduAges 18–45 - NCT07056998Enrolling by invitation
AI detects root canal quality, then retreats if needed
This trial tests whether artificial intelligence can spot problems in root canal treatments seen on special X-rays (CBCT) compared to regular X-rays. If the AI finds an issue, a retreatment is done.
Cairo, Cairo GovernorateAges 18–50 - NCT07166679Recruiting
Larger root canal tip for healing infection in back molars
This study tests whether making the tip of the root canal slightly larger during a single root canal treatment helps the infection heal better and reduces pain afterward. It is for people with a dead lower back molar that has an infection around the root tip.
RohtakAges 18–65 - NCT07206108Recruiting
Crown vs post-core for large tooth repairs after root canal
This trial compares two ways to fix large holes in premolars after root canal treatment: a modified crown attached to the remaining tooth, or a personalized post-and-crown. It looks for people with good oral health whose tooth has enough strong structure left for a successful repair.
ChinaAges 18–65 - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+ - NCT06569329Recruiting
Extra cleaning for infected root canals
This study tests if extra cleaning steps after a standard root canal can remove more bacteria from an infected tooth. It is for adults with a dead nerve and an infection at the root tip in a single-rooted premolar that has never been treated before.
Iowa City, IowaAges 18–95 - NCT07163975Recruiting
Complete Pulpotomy vs Root Canal for Diabetic Tooth Infection
This study tests whether a less invasive tooth infection treatment (complete pulpotomy) works as well as a standard root canal for people with type 2 diabetes. It is designed for adults with a specific blood sugar level who have an infected lower back tooth.
Rohtak, HaryanaAges 18–70 - NCT07242742Recruiting
Pulpotomy vs. root canal for deep cavities
This trial compares two treatments for very deep cavities that reach the tooth's nerve. It tests whether a less invasive partial nerve removal (pulpotomy) works as well as a full root canal. It may help you keep your tooth without needing a full root canal.
SingaporeAges 12 years+ - NCT07375576Recruiting
Comparing partial nerve removal to root canal for severe tooth pain
This study compares two ways to treat severe tooth pain from advanced decay: a partial nerve removal (pulpotomy) versus a full root canal treatment. It aims to find which approach works better for saving the tooth.
Hatay, AntakyaAges 18–45 - NCT07671326Recruiting
Bioceramic vs calcium hydroxide for infected molars
This study compares two types of medication placed inside a root canal to fight infection. It may be an option if you have an infected lower molar and are in generally good health.
Istanbul, IstanbulAges 18–65 - NCT06777381Enrolling by invitation
Pain after root canal treatment in lower molars
This study compares how much pain people feel after a single root canal treatment on a lower back molar. It may help find a way to reduce discomfort after the procedure.
CairoAges 25–45 - NCT05964933Enrolling by invitation
Pulpotomy vs root canal for painful nerve inflammation
This trial compares two treatments for a tooth nerve that is very inflamed and causing lingering pain: a pulpotomy versus a full root canal. It may help you choose the approach that best relieves symptoms and supports healing for the right kind of tooth.
SingaporeAges 12 years+ - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT06312085Recruiting
Root canal study with new filling material
This study tests a new material for filling root canals after cleaning out an infection. It aims to see if the material helps the tooth heal successfully. You may qualify if you have an infected tooth that has never had a root canal before.
IstanbulAges 18–75 - NCT04528979Recruiting
Tests a bioceramic filling material for root-canal treatment outcomes
This study looks at how well a bioceramic sealing material works for tooth root-canal treatment, including cases where previous treatment did not work. If you have certain types of tooth nerve inflammation or infection, you may be eligible to help compare outcomes and improve care.
Sant Cugat del Vallès, BarcelonaAges 18–75 - NCT07343804Recruiting
Dental root canal and heart disease risk study
This trial tests whether treating a tooth infection with a root canal can lower blood markers linked to heart risk in people with stable heart disease.
Rohtak, HaryanaAges 30 years+ - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT06543004Recruiting
Comparing pain after root canal with two filling materials
This study is comparing two different materials used to fill the tooth after a root canal to see which one causes less pain afterward. If you need a root canal on a front tooth or a premolar and you don't have pain or swelling, this trial may help find the gentler option for you.
DohaAges 18–60 - NCT06514053Recruiting
Predicting success of molar pulp treatment
This study looks at whether certain signs in your tooth can help predict if a special type of filling (pulpotomy) will work for deep cavities in back teeth. It may help find the best treatment for you.
Hong KongAges Any age - NCT07198919Enrolling by invitationPhase 1/Phase 2
Pain relief during root canal for infected tooth: gel vs. antibiotic paste
This trial compares two medicines placed inside a tooth after root canal cleaning to see which reduces pain better between appointments. If you have an infected single-root tooth and are between 16-45 years old, you may be able to join.
Karachi, SindhAges 16–45 - NCT07388368Recruiting
Root canal pain study: comparing two tooth fillings
This study compares two types of fillings used after a root canal to see which one causes less pain afterward. If you have a tooth with severe, constant pain that needs a root canal, this trial may help find the best option for you.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT06146894Recruiting
Comparing filling methods for tooth pain after root canal
This study compares different ways to fill a tooth's root canals after cleaning them. It looks at which method causes the least pain after a single visit root canal treatment.
Kafr ash Shaykh, Kafr El-ShaikhAges 18–60
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Common questions
- Are there clinical trials for root canal treatment?
- Yes. Clin2 currently lists 43 recruiting root canal treatment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a root canal treatment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a root canal treatment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.