Clinical trials
Schizophrenia clinical trials
Below are recruiting schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07565428RecruitingPhase 3
Study of roluperidone for negative symptoms of schizophrenia
This trial tests a new medicine called roluperidone for people with schizophrenia who have ongoing negative symptoms (like low motivation or social withdrawal) but stable positive symptoms (like hallucinations). It aims to see if the drug helps with these symptoms and if it can reduce the chance of relapse compared to other medications.
Bellflower, CaliforniaAges 18–55 - NCT07290738Recruiting
TMS for negative symptoms in schizophrenia
This study tests whether a non-invasive brain stimulation technique called TMS can help reduce negative symptoms in people with schizophrenia. These symptoms include things like lack of motivation, limited speech, and not expressing emotions.
Houston, TexasAges 18–60 - NCT07265180Recruiting
Oxytocin and group therapy for schizophrenia
This trial tests whether adding oxytocin (a hormone that helps with social bonding) to group therapy can improve symptoms and social functioning in people with schizophrenia. It compares two different doses of oxytocin to see which works better.
Berlin, State of BerlinAges 18–75 - NCT07074704Enrolling by invitation
Brain stimulation to improve symptoms and thinking in schizophrenia
This study tests whether a gentle electrical current applied to the scalp (transcranial alternating current stimulation, or tACS) can help reduce negative symptoms and improve thinking in people with long-term schizophrenia. It is for patients who have been hospitalized for over six months and are on stable medication.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07423546RecruitingPhase 1/Phase 2
Brain scan study of Cobenfy in schizophrenia
This study tests a new medication called Cobenfy (also known as trospium) using brain scans to see how it affects dopamine in people with schizophrenia. If you have schizophrenia and are not currently on antipsychotics, you may be able to join.
New York, New YorkAges 18–50 - NCT07521683Enrolling by invitationPhase 2
NS-136 treatment study for schizophrenia relapse
This study tests whether NS-136, a new medication, can help people with schizophrenia who are experiencing a relapse or worsening of symptoms. The study measures how well the medication works and what side effects it causes.
ShanghaiAges 18–65 - NCT07060066Recruiting
TMS for depression in schizophrenia
This study tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation) can help with depression in people who have schizophrenia. You would receive TMS sessions targeting areas of the brain linked to mood, and the goal is to see if this improves depression symptoms.
Houston, TexasAges 18–60 - NCT07734493RecruitingPhase 1
Study of a new drug for acute schizophrenia symptoms
This trial tests an experimental medicine, LTX-001, for people with schizophrenia who are currently having a sudden worsening of symptoms. It aims to see if the drug can help reduce these acute symptoms.
Little Rock, ArkansasAges 18–55 - NCT07184619RecruitingPhase 3
Evenamide for hard-to-treat schizophrenia (add-on study)
This trial tests a new medication, evenamide, added to your current antipsychotic treatment. It looks to see if it can help people whose schizophrenia has not responded well to standard therapies.
Los Angeles, CaliforniaAges 18 years+ - NCT07467993RecruitingPhase 2
Testing GXV813 for hospitalized adults with schizophrenia
This trial tests a new drug, GXV813, to see if it helps reduce symptoms in people with schizophrenia who are currently hospitalized due to a sudden worsening of their condition. It compares the drug's safety and effect against a placebo over several weeks.
Bentonville, ArkansasAges 18–65 - NCT07121166Recruiting
Family therapy by video for schizophrenia
This trial tests a family therapy program delivered through video calls to help people with schizophrenia and their families. You would join group sessions with other families to learn ways to support each other and reduce stress.
Chai WanAges 18–64 - NCT07288333RecruitingPhase 2
New medication for schizophrenia in hospitalized adults
This study tests an experimental medication (NBI-1117570) for adults with schizophrenia who are currently in the hospital because of a sudden worsening of symptoms. The goal is to see if this new treatment can help control symptoms better.
KazanlakAges 18–55 - NCT07680946RecruitingPhase 2
Testing ublituximab for treatment-resistant schizophrenia
This trial tests an experimental drug, ublituximab, to see if it helps people with schizophrenia that hasn't gotten better with standard treatments. It may offer a new option for those who still have significant symptoms despite current therapy.
Little Rock, ArkansasAges 18–60 - NCT07424404RecruitingPhase 3
Long-term safety trial for teens with schizophrenia or autism irritability
This trial looks at the long-term safety of KarXT, a medication for schizophrenia, and KarX-EC for irritability related to autism in teenagers. It is for teens who have already completed the main part of a previous study without serious side effects.
Dothan, AlabamaAges 5–17 - NCT07288567RecruitingPhase 3
KarXT for teens with schizophrenia
This trial tests if a new medicine, KarXT, can safely and effectively treat schizophrenia in adolescents. It may help teenagers who have active symptoms like hallucinations or disorganized thinking.
Anaheim, CaliforniaAges 13–17 - NCT05770375RecruitingPhase 1/Phase 2
Testing how safe MDMA is for people with schizophrenia
This early-phase study looks at whether MDMA is tolerable (safe enough) in people diagnosed with schizophrenia. Researchers will check safety while you stay stable on your usual care.
Los Angeles, CaliforniaAges 18–60 - NCT07647380Recruiting
Brain Stimulation to Help Thinking in Schizophrenia
This trial tests a non-invasive brain stimulation technique called transcranial electrical stimulation (TIS) to improve thinking and memory problems in people with schizophrenia. Researchers want to see if this treatment, combined with antipsychotic medications, can help you think more clearly and function better in daily life.
Changsha, HunanAges 18–50 - NCT07446478Recruiting
TIS for improving thinking problems in schizophrenia
This trial tests if a brain stimulation technique called transcranial electrical stimulation (TIS) can help improve cognitive problems (like memory and attention) in people with schizophrenia. You may join if you are between 18 and 50, have had schizophrenia for no more than 8 years, take 1-2 antipsychotic medicines, and have some trouble with daily activities.
Changsha, HunanAges 18–50 - NCT03094429RecruitingPhase 2/Phase 3
Testing NaBen add-on to clozapine for tough schizophrenia symptoms
This trial tests whether adding NaBen (a supplement-like medicine) to clozapine can improve “residual” symptoms in adults with difficult-to-treat schizophrenia. The study also checks safety and the best dose, using a placebo (inactive pill) for comparison.
Pasadena, CaliforniaAges 18–55 - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT03525054Recruiting
Brain-and-speech study after suicidal thoughts or actions
This study looks at how people use language (free speech) after a suicidal gesture, idea, or related behavior that affected their life. The researchers use computer-based analysis to understand patterns in speech and thinking, which may help improve support and assessment.
BrestAges 15–30 - NCT03794076RecruitingPhase 1/Phase 2
Testing adjunct cromoglicate for schizophrenia symptoms
This trial studies whether adding cromoglicate to your usual antipsychotic medicine can improve schizophrenia symptoms. It’s designed for outpatients who are already on a stable treatment and still have certain ongoing symptom scores.
Pittsburgh, PennsylvaniaAges 18–65 - NCT03817502RecruitingPhase 3
Cariprazine test for teens with schizophrenia
This trial tests whether cariprazine works and is safe for teens aged 13 to 17 with schizophrenia. It may help if your symptoms are still moderate to severe despite current care.
Culver City, CaliforniaAges 13–17 - NCT07701343Recruiting
Brain stimulation for memory in schizophrenia
This trial tests whether a gentle electrical brain stimulation technique called tACS can improve working memory in people with schizophrenia. It involves 10 daily sessions and may help with daily functioning.
Changsha, HunanAges 18–50
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Common questions
- Are there clinical trials for schizophrenia?
- Yes. Clin2 currently lists 317 recruiting schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.