Clinical trials
Treatment Resistant Schizophrenia clinical trials
Below are recruiting treatment resistant schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 71 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07758010Recruiting
Brain stimulation for treatment-resistant depression
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
Belmont, MassachusettsAges 18 years+ - NCT07741981Recruiting
Biological markers for treatment-resistant psychiatric disorders
This study looks for biological markers in the blood or spinal fluid that might predict how well a new psychiatric treatment will work. If you have a psychiatric condition that hasn't improved with previous treatments, this research could help find better ways to match treatments to individuals in the future.
ParisAges 18 years+ - NCT07184619RecruitingPhase 3
Evenamide for hard-to-treat schizophrenia (add-on study)
This trial tests a new medication, evenamide, added to your current antipsychotic treatment. It looks to see if it can help people whose schizophrenia has not responded well to standard therapies.
Los Angeles, CaliforniaAges 18 years+ - NCT06749444Recruiting
Cognitive behavioral therapy for sleep issues in schizophrenia
This trial tests if a talking therapy focused on sleep and daily rhythms (CBT-I) can help people with schizophrenia who have not responded well to other treatments and have trouble sleeping. It aims to improve sleep quality without medication.
Glostrup, DenmarkAges 18–64 - NCT06672588Recruiting
Magnetic seizure therapy for schizophrenia
This trial tests a new type of brain stimulation called magnetic seizure therapy (MST) for people with schizophrenia who haven't gotten better with standard medicines. The goal is to see if MST can help reduce symptoms like hallucinations or confusion.
Vancouver, British ColumbiaAges 18 years+ - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65 - NCT06456983Recruiting
Maintenance ECT for hard-to-treat schizophrenia
This trial tests if regular electroconvulsive therapy (ECT) can help people whose schizophrenia has not improved with clozapine or who cannot take clozapine. Researchers will see if maintenance ECT helps prevent symptoms from returning.
AachenAges 18–75 - NCT05299749Recruiting
Brain training using real-time fMRI for hearing voices in schizophrenia
This trial tests whether real-time brain imaging “neurofeedback” can help people with schizophrenia who have ongoing auditory hallucinations (hearing voices) that haven’t improved with medications. If you qualify, you may complete brain-scanning sessions where you practice changing brain activity while being monitored.
Brockton, MassachusettsAges 18–55 - NCT06361160Recruiting
Brain stimulation for treatment-resistant voices in schizophrenia
This trial tests a brain stimulation treatment (rTMS) to help reduce the frequency and intensity of voices people with schizophrenia hear. It is for individuals who continue to hear voices frequently despite trying multiple medications.
ParisAges 18 years+ - NCT05958875RecruitingPhase 4
Six-week medicine switch for schizophrenia after first treatment failure
This trial tests whether a more intensive medication approach for schizophrenia (or related conditions) helps people who didn’t improve on their first tried medicine. Participants will usually switch medicines and be compared against “treatment as usual.”
InnsbruckAges 18–70 - NCT04887792RecruitingPhase 1/Phase 2
Acetazolamide for schizophrenia that hasn’t improved
This Phase 1/2 study tests whether acetazolamide can help people with treatment-resistant schizophrenia. It aims to see if adding this medication improves symptoms when standard antipsychotics haven’t worked enough.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07843927RecruitingPhase 3
Adding DHEA hormone to antidepressants for difficult depression
This study tests whether adding a natural hormone called DHEA to your regular antidepressant can help improve depression symptoms. DHEA is a supplement that may boost the effectiveness of standard antidepressants for people with hard-to-treat depression.
Berlin, State of BerlinAges 18–75 - NCT06895863Recruiting
Personalized magnetic brain therapy for hard to treat depression
This study tests a new way to use magnetic brain stimulation tailored to each patient to treat depression that hasn't improved with at least two different medications. It may help people who are still struggling with moderate to severe depression.
Glostrup MunicipalityAges 18–95 - NCT06044324Enrolling by invitation
Imaging brain activity in TMS for depression
This trial uses PET scans to see how transcranial magnetic stimulation (TMS) affects the brain in people whose depression hasn't improved with at least two different antidepressants. It aims to find markers that could predict who might benefit from TMS.
Hangzhou, ZhejiangAges 18–45 - NCT05660642RecruitingPhase 2
Safety and tolerability study for BPL-003 in hard-to-treat depression
This Phase 2 study tests BPL-003 in people with treatment-resistant depression to learn about its safety and how it affects the body and brain. Because it is open-label, everyone knows they are getting the study treatment, and you’ll also need to stop your current antidepressant during the study.
LiverpoolAges 18–75 - NCT05577247Recruiting
Study of new thinking skills in hard-to-treat depression
This trial looks at how people with treatment-resistant major depression respond when starting a new depression medicine that affects glutamate signaling. It also involves brain scans and thinking/learning tasks, aiming to understand what helps people improve when standard treatments haven’t worked.
ParisAges 18–70 - NCT05240976RecruitingPhase 2
Testing add-on treatments for very treatment-resistant schizophrenia
This trial tests a combination of an NMDA-targeting medicine and an anti-inflammatory treatment for people with schizophrenia that has not responded well to several standard treatments, including clozapine. If you qualify, the goal is to see whether this combination improves symptoms more than usual care.
TaichungAges 18–65 - NCT04124341Recruiting
Brain stimulation for treatment-resistant depression
This study tests a new brain stimulation treatment for people with severe depression that hasn't improved with standard treatments. You must have tried at least four different depression treatments without success, and either had or refused electroconvulsive therapy (ECT). You’ll need to be under a psychiatrist’s care and be enrolled in Medicare. The study involves brain scans and EEG sessions to tailor the treatment to you.
Minneapolis, MinnesotaAges 22–70 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT05607654Recruiting
Brain stimulation for depression that hasn’t improved with usual treatment
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
Hangzhou, ZhejiangAges 18–45 - NCT07673913Recruiting
Blood markers and brain stimulation for hard-to-treat depression
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
Ankara, AnkaraAges 18–55 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT07369102RecruitingPhase 4
Esketamine with or without talk therapy for tough depression
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
San JuanAges 21–65 - NCT07211438RecruitingPhase 2
Psilocybin with Monitors for Treatment-Resistant Depression
This study tests whether trained monitors improve the safety and outcomes of psilocybin therapy for people with depression that hasn't responded to other treatments. Participants will receive psilocybin in a supervised setting and will need to temporarily stop other psychiatric medications.
Toronto, OntarioAges 18–70
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Common questions
- Are there clinical trials for treatment resistant schizophrenia?
- Yes. Clin2 currently lists 71 recruiting treatment resistant schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment resistant schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment resistant schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.