Clinical trials
Treatment Resistant Schizophrenia clinical trials
Below are recruiting treatment resistant schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 65 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07184619RecruitingPhase 3
Evenamide for hard-to-treat schizophrenia (add-on study)
This trial tests a new medication, evenamide, added to your current antipsychotic treatment. It looks to see if it can help people whose schizophrenia has not responded well to standard therapies.
Los Angeles, CaliforniaAges 18 years+ - NCT05299749Recruiting
Brain training using real-time fMRI for hearing voices in schizophrenia
This trial tests whether real-time brain imaging “neurofeedback” can help people with schizophrenia who have ongoing auditory hallucinations (hearing voices) that haven’t improved with medications. If you qualify, you may complete brain-scanning sessions where you practice changing brain activity while being monitored.
Brockton, MassachusettsAges 18–55 - NCT05958875RecruitingPhase 4
Six-week medicine switch for schizophrenia after first treatment failure
This trial tests whether a more intensive medication approach for schizophrenia (or related conditions) helps people who didn’t improve on their first tried medicine. Participants will usually switch medicines and be compared against “treatment as usual.”
InnsbruckAges 18–70 - NCT06361160Recruiting
Brain stimulation for treatment-resistant voices in schizophrenia
This trial tests a brain stimulation treatment (rTMS) to help reduce the frequency and intensity of voices people with schizophrenia hear. It is for individuals who continue to hear voices frequently despite trying multiple medications.
ParisAges 18 years+ - NCT06456983Recruiting
Maintenance ECT for hard-to-treat schizophrenia
This trial tests if regular electroconvulsive therapy (ECT) can help people whose schizophrenia has not improved with clozapine or who cannot take clozapine. Researchers will see if maintenance ECT helps prevent symptoms from returning.
AachenAges 18–75 - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65 - NCT06672588Recruiting
Magnetic seizure therapy for schizophrenia
This trial tests a new type of brain stimulation called magnetic seizure therapy (MST) for people with schizophrenia who haven't gotten better with standard medicines. The goal is to see if MST can help reduce symptoms like hallucinations or confusion.
Vancouver, British ColumbiaAges 18 years+ - NCT04887792RecruitingPhase 1/Phase 2
Acetazolamide for schizophrenia that hasn’t improved
This Phase 1/2 study tests whether acetazolamide can help people with treatment-resistant schizophrenia. It aims to see if adding this medication improves symptoms when standard antipsychotics haven’t worked enough.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06749444Recruiting
Cognitive behavioral therapy for sleep issues in schizophrenia
This trial tests if a talking therapy focused on sleep and daily rhythms (CBT-I) can help people with schizophrenia who have not responded well to other treatments and have trouble sleeping. It aims to improve sleep quality without medication.
Glostrup, DenmarkAges 18–64 - NCT04124341Recruiting
Brain stimulation for treatment-resistant depression
This study tests a new brain stimulation treatment for people with severe depression that hasn't improved with standard treatments. You must have tried at least four different depression treatments without success, and either had or refused electroconvulsive therapy (ECT). You’ll need to be under a psychiatrist’s care and be enrolled in Medicare. The study involves brain scans and EEG sessions to tailor the treatment to you.
Minneapolis, MinnesotaAges 22–70 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT05240976RecruitingPhase 2
Testing add-on treatments for very treatment-resistant schizophrenia
This trial tests a combination of an NMDA-targeting medicine and an anti-inflammatory treatment for people with schizophrenia that has not responded well to several standard treatments, including clozapine. If you qualify, the goal is to see whether this combination improves symptoms more than usual care.
TaichungAges 18–65 - NCT05577247Recruiting
Study of new thinking skills in hard-to-treat depression
This trial looks at how people with treatment-resistant major depression respond when starting a new depression medicine that affects glutamate signaling. It also involves brain scans and thinking/learning tasks, aiming to understand what helps people improve when standard treatments haven’t worked.
ParisAges 18–70 - NCT05660642RecruitingPhase 2
Safety and tolerability study for BPL-003 in hard-to-treat depression
This Phase 2 study tests BPL-003 in people with treatment-resistant depression to learn about its safety and how it affects the body and brain. Because it is open-label, everyone knows they are getting the study treatment, and you’ll also need to stop your current antidepressant during the study.
LiverpoolAges 18–75 - NCT06895863Recruiting
Personalized magnetic brain therapy for hard to treat depression
This study tests a new way to use magnetic brain stimulation tailored to each patient to treat depression that hasn't improved with at least two different medications. It may help people who are still struggling with moderate to severe depression.
Glostrup MunicipalityAges 18–95 - NCT06044324Enrolling by invitation
Imaging brain activity in TMS for depression
This trial uses PET scans to see how transcranial magnetic stimulation (TMS) affects the brain in people whose depression hasn't improved with at least two different antidepressants. It aims to find markers that could predict who might benefit from TMS.
Hangzhou, ZhejiangAges 18–45 - NCT07211438RecruitingPhase 2
Psilocybin with Monitors for Treatment-Resistant Depression
This study tests whether trained monitors improve the safety and outcomes of psilocybin therapy for people with depression that hasn't responded to other treatments. Participants will receive psilocybin in a supervised setting and will need to temporarily stop other psychiatric medications.
Toronto, OntarioAges 18–70 - NCT05607654Recruiting
Brain stimulation for depression that hasn’t improved with usual treatment
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
Hangzhou, ZhejiangAges 18–45 - NCT06512220RecruitingPhase 2
Psilocybin for treatment-resistant depression brain imaging study
This study tests whether a psilocybin-based treatment can help people with depression that has not improved after trying several antidepressants. You will receive the study treatment and have brain scans to see how it affects brain connections.
Toronto, OntarioAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Tucson, ArizonaAges 18–65 - NCT07166289Recruiting
Ultrasound treatment for tough depression
This study uses focused ultrasound to stimulate brain circuits in people with treatment-resistant depression. It aims to see if this can help when other treatments haven't worked.
Tulsa, OklahomaAges 18–65 - NCT07369102RecruitingPhase 4
Esketamine with or without talk therapy for tough depression
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
San JuanAges 21–65 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT06340789RecruitingPhase 2
Sodium Benzoate Added to Antipsychotics for Resistant Schizophrenia
This study tests whether adding a supplement called sodium benzoate to your current antipsychotic medication can improve symptoms in schizophrenia that hasn't responded well to standard treatments. Researchers will measure brain chemistry changes and symptom improvement over time.
Chiayi CityAges 20–55
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Common questions
- Are there clinical trials for treatment resistant schizophrenia?
- Yes. Clin2 currently lists 65 recruiting treatment resistant schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment resistant schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment resistant schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.