Clinical trials
Sciatica clinical trials
Below are recruiting sciatica clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03924791Recruiting
Epidural injection trial for acute sciatica pain
This study tests whether a specific back/nerve pain injection (an epidural injection) can help people with acute sciatica. You may qualify if your sciatica started a few weeks ago and your leg pain is still quite severe.
HaarlemAges 18 years+ - NCT06696898Recruiting
Stretching with and without muscle release for sciatica
This study tests if adding myofascial release (a type of hands-on therapy for tight muscles) to a standard self-stretching program helps relieve sciatica pain and improve movement. It's for people with long-standing (chronic) one-sided sciatica.
Lahore, Punjab ProvinceAges 25–50 - NCT07632612Recruiting
Nerve-Stretching Techniques for Sciatica Pain Relief
This trial compares two hands-on physical therapy techniques—one that stretches the sciatic nerve and one that moves it gently—to see which works better for sciatica pain that has lasted several months. You'll receive one of these treatments to help reduce leg pain and improve your ability to walk and move.
Rawalpindi, Punjab ProvinceAges 20–50 - NCT07756905Recruiting
Motor control exercises with and without tape for sciatica
This study tests whether adding kinesio tape (a flexible, supportive tape) to a motor control exercise program helps reduce sciatica pain more than exercises alone. It may help improve movement and reduce pain in your leg.
SialkotAges 35–50 - NCT06536829Recruiting
Muscle release and nerve gliding for sciatica in cricketers
This study tests two hands-on treatments—myofascial release and sciatic nerve slider exercises—to see which helps male cricketers with sciatica feel less pain and move better.
Lahore, Punjab ProvinceAges 18–35 - NCT07690449Recruiting
CT signs of nerve irritation in sciatica
This study looks at three specific signs on a CT scan that may show nerve-root irritation in people with sciatica. It only includes patients who are already scheduled for a CT-guided nerve injection to treat their pain.
Nice, Alpes MaritimesAges 18 years+ - NCT07161323Recruiting
Trial of two exercises for leg pain from sciatica
This trial compares two simple exercises (SNAG and SNME) to see which works better for people with long-lasting sciatic leg pain. If you have had pain going down one leg for over 3 months and have not had treatment in the last month, this study may help find relief.
IstanbulAges 20–50 - NCT07444125Recruiting
Leg rotation treatment for sciatica
This trial tests a two-leg rotation technique to relieve sciatica caused by lumbar disc problems. It may help if you have pain that travels from your lower back down past your knee.
Ha'il, Ha'il RegionAges 18–50 - NCT07125027Recruiting
Exercise and mindfulness for sciatica pain
This study tests a program called Move-MORE that combines exercise and mindfulness to help people with nerve-related leg pain (sciatica) that has lasted at least 3 months. You would use the program at home, attend weekly video sessions for 8 weeks, and complete questionnaires and daily surveys to see if the program improves your pain and quality of life.
Portland, OregonAges 18–75 - NCT07762170RecruitingPhase 4
Steroid injections for back and pelvic pain
This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.
Thornhill, OntarioAges 18 years+ - NCT04540068Recruiting
Predicting whether a sciatica procedure will work
This study looks for ways to predict how well a specific sciatica procedure (TEI) will help. If you have one-sided nerve pain from the low back, the trial may help personalize treatment so you’re less likely to go through ineffective care.
HaarlemAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT06157177RecruitingPhase 4
M640 for acute low back pain study
This trial tests a new treatment (M640) for people with acute low back pain, with or without sciatica. It aims to see if M640 can help reduce pain quickly.
Auburn, AlabamaAges 18–80 - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT07373808Recruiting
Nerve stimulation and exercise for sciatica leg pain
This study tests whether combining a mild electrical stimulation of the sciatic nerve with specific exercises can reduce leg pain from sciatica. It is for people whose nerve-related leg pain has lasted over 6 months and is at least a 3 out of 10 in intensity.
Madrid, MadridAges 18–70 - NCT07377357Recruiting
Electrical stimulation for chronic back-related leg pain
This trial tests if a single session of electrical stimulation to the sciatic nerve can quickly reduce leg pain related to low back problems. It may help if you have had chronic sciatica (leg pain from your back) for more than 6 months and your pain has recently been interfering with daily life.
Madrid, MadridAges 18–70 - NCT07397117Recruiting
Ultrasound-guided nerve block for sciatica pain
This trial tests if an ultrasound-guided nerve block can provide better pain relief for sciatica compared to standard care. If you have severe leg pain from sciatica, this study might help you find effective pain control.
San Francisco, CaliforniaAges 18 years+ - NCT07418944Recruiting
Surgery vs. non-surgery for leg pain from a slipped disc
This trial compares surgery to non-surgical treatments for people with leg pain caused by a lumbar disc herniation (slipped disc). It tests if surgery provides better relief after at least 6 weeks of symptoms.
HelsinkiAges 18–60
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Common questions
- Are there clinical trials for sciatica?
- Yes. Clin2 currently lists 18 recruiting sciatica studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sciatica trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sciatica trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.