Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05534568Recruiting
Parent support program for families affected by pregnancy substance use
This program aims to help mothers and young children get safer, better support services when substance use occurred during pregnancy. It may help connect you (or your child) to the right community resources and reduce risk of ongoing alcohol or drug exposure.
Oklahoma City, OklahomaAges 18 years+ - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT03135886Recruiting
Testing for HIV in opioid treatment programs
This project studies how to improve offering and completing HIV (and hepatitis C) tests in opioid treatment programs. It may help increase timely follow-up and linkage to care when results are positive.
New York, New YorkAges 18 years+ - NCT06513156Recruiting
Care support for hospitalized patients with drug-related infections
This study is for people who are in the hospital with a serious infection caused by injection drug use. It aims to provide better care and support while you are in the hospital and after you leave.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06852170Recruiting
Data-driven decisions for substance use services
This trial helps decision-makers use data to improve substance use services and prevent overdoses. It is for professionals who shape policy or run programs in behavioral health, public health, law enforcement, or advocacy.
Eugene, OregonAges 18 years+ - NCT07199335RecruitingPhase 4
Injectable HIV prevention drug for people who inject drugs
This study tests a long-acting injectable medication called cabotegravir to prevent HIV in people who inject drugs. If you have injected street drugs recently, you may be able to get this shot every few months instead of taking daily pills.
Boston, MassachusettsAges 18 years+ - NCT06995885Enrolling by invitation
A study to improve tracking of opioid use in the fentanyl era
This study aims to develop a better tool for recalling and tracking opioid use patterns, especially with fentanyl. It may help people who use opioids outside of medical settings to more accurately report their use.
Baltimore, MarylandAges 18–99 - NCT06424184Recruiting
Fast brain stimulation for addiction and depression
This study tests a quick, non-invasive brain stimulation method (rTMS) to help people who use stimulants like cocaine or methamphetamine and also feel depressed. The goal is to see if it can reduce cravings and improve mood.
Dallas, TexasAges 18–65 - NCT07734623Recruiting
Ultrasound treatment for severe opioid or amphetamine use disorder
This trial tests a low-intensity focused ultrasound treatment for people with severe opioid or amphetamine use disorder. The ultrasound targets a part of the brain linked to addiction, and the goal is to see if it is safe and helpful.
TaipeiAges 20–50 - NCT07197476Recruiting
Helping teens after a traumatic injury
This study tests a program to help teens who have been in the hospital for a traumatic injury. It aims to reduce stress and substance use by offering a supportive intervention.
Providence, Rhode IslandAges 12–17 - NCT05169385Recruiting
Parent support for teens in residential treatment for substance misuse
This trial tests a parent-focused program (via interviews and texting) for families when a teen is leaving residential treatment. It aims to help parents/guardians support their teen after discharge and reduce substance-related risk.
Rockford, IllinoisAges 12–18 - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT06307977Recruiting
Couples counseling to reduce drug use and HIV risk
This study tests a couple-focused counseling approach to help male couples reduce drug use and lower the risk of HIV. You and your partner would join sessions together to talk about safer choices and support each other.
Detroit, MichiganAges 18–55 - NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT06262958Recruiting
Early help for teen alcohol and substance issues
This study looks at early help for alcohol and substance use in teenagers. The goal is to see if early support can improve outcomes for young people who have been treated at a psychiatric clinic.
KuopioAges 14–19 - NCT04723498Recruiting
Internet use study for children and teens
This study looks at how problematic (hard-to-control) internet use shows up in children and teens. It may help clinicians understand the patterns of use and improve support for young people and families.
Zurich, Canton of ZurichAges 8–18 - NCT05547048RecruitingPhase 4
Phone-based support to help prevent HIV in justice-involved women
This study tests an integrated phone-based health program (e-health) designed for women involved with the justice system who have opioid use disorder. It aims to help people who qualify for HIV prevention (PrEP) stay protected, especially by using simple, ongoing support through phone access.
Birmingham, AlabamaAges 18 years+ - NCT07330349Recruiting
Trauma and substance use in penetrating abdominal injury
This study looks at alcohol, drug use, and painkiller use in people with a penetrating abdominal injury (like a stab or gunshot wound to the belly). It aims to understand how these substances affect patient outcomes.
Cali, Valle del Cauca DepartmentAges 15 years+ - NCT06639373Recruiting
Road to Recovery Initiative
This study looks at how people recover when they use Road to Recovery services in British Columbia. If you have used these services before, you may be able to share your experiences to help improve recovery support for others.
Vancouver, British ColumbiaAges 18 years+ - NCT06858527Recruiting
Combined ADHD and substance use treatment study
This study tests a combined treatment for adults who have both ADHD and a substance use disorder. It looks at whether an integrated approach helps people better manage both conditions together.
ParisAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT05910580Recruiting
Screening and support for alcohol and substance risk in adults
This study aims to improve care access and outcomes for adults who screen positive for risky alcohol or drug use. If you qualify, you may be offered ways to connect to support during your reproductive years.
Boston, MassachusettsAges 18 years+ - NCT06679062RecruitingPhase 2
Suvorexant for alcohol use disorder and PTSD
This study tests whether the sleep medication suvorexant can help people with both alcohol use disorder and PTSD. If you're struggling with drinking, PTSD symptoms, and poor sleep, this trial may offer a new treatment option.
Los Angeles, CaliforniaAges 21–65 - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.