Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06074354Recruiting
MY-RIDE app for HIV prevention and substance use in homeless youth
This study tests a smartphone app called MY-RIDE to help homeless youth prevent HIV and reduce substance use. The app sends helpful tips at the right time to support healthier choices.
Houston, TexasAges 18–25 - NCT06413979Recruiting
Family support program for teens with substance use and mood or anxiety issues
This trial offers a family support program for teens with both substance use and internalizing problems like depression or anxiety. The goal is to help you and your caregiver work together to manage symptoms and improve well-being.
Jacksonville, FloridaAges 13–21 - NCT06335407RecruitingPhase 1
Testing a new under-the-tongue med for alcohol use and trauma
This study tests a new sublingual (under-the-tongue) medication for people with alcohol use disorder who have also had a traumatic life event. It aims to see if the medication can help reduce drinking and related symptoms.
West Haven, ConnecticutAges 21–65 - NCT05964010Recruiting
Parent-and-teen program for teen health visits
This trial offers a structured support program for teenagers and their primary caregiver during a primary care visit. It may help by testing an approach that connects youth and families with resources and support starting at the clinic visit.
New York, New YorkAges 12–17 - NCT04366531Recruiting
Support for veterans after prison release
This study tests a program to help veterans with mental health or substance use issues transition from prison back into civilian life. It may provide support to improve reintegration and reduce the risk of returning to prison.
Dallas, TexasAges 18 years+ - NCT07637669Recruiting
Smell and decision-making in people with HIV and substance use
This study looks at how smell and decision-making are affected in people living with HIV and/or substance use disorders. You may join one of four groups based on your HIV status and substance use history, and you will complete smell tests and computer tasks, with an optional MRI.
Baltimore, MarylandAges 18–65 - NCT05253235Recruiting
Health and resilience program for Black youth and their caregivers
This study tests a “health and resilience” support program for Black/African American youth and their primary caregiver, using questionnaires and possibly brain scans. It may help families build coping skills and track changes in health-related responses over time.
Athens, GeorgiaAges 10–13 - NCT05768815Recruiting
Services for families with young children after early adversity
This study compares two programs that aim to improve mental health for parents and families with babies and young children who have faced early difficulties. It may help you see which approach works best for supporting your child and family.
Surrey, British ColumbiaAges Any age - NCT07804121Recruiting
Police training to support public health in Kentucky
This study tests a training program for police officers to help them support public health in their communities. It may benefit officers by giving them tools to respond better to health-related situations.
Lexington, KentuckyAges 18 years+ - NCT07768007Recruiting
Methadone and memory study for opioid use disorder
This study tests whether a new approach can improve memory and mood in people taking methadone for opioid use disorder. It involves brain scans and may help with feelings of sadness or loss of interest.
New Haven, ConnecticutAges 18–50 - NCT06128772Recruiting
Acupuncture study for chronic pain
This study tests if battlefield acupuncture, a specific type of ear acupuncture using tiny needles or tacks, can help veterans with chronic pain. It may be a good option if you have a history of substance use disorder and are interested in a non-drug approach to pain relief over 16 weeks.
Bedford, MassachusettsAges 18 years+ - NCT07759882Recruiting
PTSD care for new mothers in substance use treatment
This study offers screening and treatment for pregnant or new mothers who have both substance use problems and post-traumatic stress disorder (PTSD). The goal is to help you recover from trauma and build a healthier life for you and your baby.
Little Rock, ArkansasAges 18 years+ - NCT07742722Recruiting
Peer support for veterans with mental health and substance use issues
This study tests a program where trained peer supporters help veterans who have been involved with the justice system and have mental health or substance use issues. It aims to improve their well-being and recovery.
Bedford, MassachusettsAges 18 years+ - NCT07741825Recruiting
Mindfulness training to prevent relapse for peer support workers
This study tests a mindfulness-based program to help people who work as peer support specialists in substance use recovery reduce their risk of relapse. It may help you manage cravings and stay healthy in your role.
Austin, TexasAges 18–100 - NCT07740395Recruiting
Support app for people in recovery and their loved ones
This study tests a support app (KulaMind-Recovery) that helps people in recovery stay connected with a loved one. You and someone important to you would both use the app to see if it helps your recovery journey.
Providence, Rhode IslandAges 18 years+ - NCT07731295Recruiting
Pain management study for teens getting wisdom teeth removed
This study looks at how to improve pain management after wisdom tooth extraction. It focuses on teens and young adults who use cannabis regularly, to see how it affects pain and recovery.
Providence, Rhode IslandAges 15–20 - NCT07707115Recruiting
Simulation training for resilience and empathy in birth care
This trial tests a simulation program to improve resilience and empathy among healthcare workers who interact with birthing individuals at the University of Utah Hospital. It may help you better cope with stress and connect with patients.
Salt Lake City, UtahAges 18 years+ - NCT07595614Recruiting
Weekly Writing to Track Recovery Progress in Substance Use
This study asks men in residential treatment for substance use to write weekly reflections about their recovery. Researchers will analyze these writings to better understand how people progress through treatment and improve how clinicians support recovery.
Potrerillos, JaliscoAges 18 years+ - NCT06738953Recruiting
Preventing mental disorders with a self-efficacy course
This trial tests if a course designed to boost your belief in your own abilities can help prevent anxiety, mood, or substance use disorders. It is for young adults who currently feel less confident in handling challenges.
Potsdam, BrandenburgAges 18–30 - NCT06558825Recruiting
PrEP support for women with trauma history
This study tests a program to help women who have experienced trauma and are at risk for HIV start and stay on PrEP (a daily pill that prevents HIV). It looks at whether mental health treatment can boost PrEP use.
Houston, TexasAges 18 years+ - NCT07519759Recruiting
Support Program for Loved Ones in Recovery
This pilot study tests a program that helps family members and close friends support someone who recently completed an inpatient or residential treatment program for substance use. The goal is to strengthen recovery by improving communication and support between the person in recovery and their loved ones.
Belmont, MassachusettsAges 18 years+ - NCT07512869Recruiting
Harm Reduction Support for Men Who Have Sex With Men in Bangkok
This study explores ways to support men who have sex with men (MSM) in Bangkok who use drugs during sexual activities, called 'chemsex.' Researchers want to understand how community leaders, healthcare workers, and police can work together to keep people safer and healthier.
Pathum Wan, BangkokAges 18 years+ - NCT07505875Recruiting
Study to create transgender-friendly services for chemsex support
This study aims to develop healthcare services tailored to transgender people regarding chemsex (using drugs during sex). Researchers will interview participants to understand their needs and experiences.
Pathum Wan, BangkokAges 18 years+ - NCT07443033Recruiting
Psychosocial factors in dual diagnosis for hospital patients
This study looks at the emotional and social factors that affect people with a dual diagnosis, which means having both a mental health condition and a substance use problem. By understanding these factors, doctors hope to improve care for patients during their hospital stay.
Plasencia, CaceresAges 18 years+
Hear when a new Substance Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.