Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 220 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05380765Recruiting
Help for First Nation teens to prevent substance use
This trial tests a positive, prevention-focused approach to help North American Indian (First Nation) teens make healthier choices about substance use. It involves both teens and an adult family member who supports good decision-making.
Kingston, Rhode IslandAges 10–14 - NCT07330349Recruiting
Trauma and substance use in penetrating abdominal injury
This study looks at alcohol, drug use, and painkiller use in people with a penetrating abdominal injury (like a stab or gunshot wound to the belly). It aims to understand how these substances affect patient outcomes.
Cali, Valle del Cauca DepartmentAges 15 years+ - NCT06639373Recruiting
Road to Recovery Initiative
This study looks at how people recover when they use Road to Recovery services in British Columbia. If you have used these services before, you may be able to share your experiences to help improve recovery support for others.
Vancouver, British ColumbiaAges 18 years+ - NCT06858527Recruiting
Combined ADHD and substance use treatment study
This study tests a combined treatment for adults who have both ADHD and a substance use disorder. It looks at whether an integrated approach helps people better manage both conditions together.
ParisAges 18 years+ - NCT06065553Recruiting
Prevalence of mental health issues in homeless or precarious people in Cayenne
This study looks at how common mental health and substance use problems are among people in difficult living situations in Cayenne. Understanding this can help create better support services.
CayenneAges 18–99 - NCT05910580Recruiting
Screening and support for alcohol and substance risk in adults
This study aims to improve care access and outcomes for adults who screen positive for risky alcohol or drug use. If you qualify, you may be offered ways to connect to support during your reproductive years.
Boston, MassachusettsAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT06679062RecruitingPhase 2
Suvorexant for alcohol use disorder and PTSD
This study tests whether the sleep medication suvorexant can help people with both alcohol use disorder and PTSD. If you're struggling with drinking, PTSD symptoms, and poor sleep, this trial may offer a new treatment option.
Los Angeles, CaliforniaAges 21–65 - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06074354Recruiting
MY-RIDE app for HIV prevention and substance use in homeless youth
This study tests a smartphone app called MY-RIDE to help homeless youth prevent HIV and reduce substance use. The app sends helpful tips at the right time to support healthier choices.
Houston, TexasAges 18–25 - NCT06413979Recruiting
Family support program for teens with substance use and mood or anxiety issues
This trial offers a family support program for teens with both substance use and internalizing problems like depression or anxiety. The goal is to help you and your caregiver work together to manage symptoms and improve well-being.
Jacksonville, FloridaAges 13–21 - NCT06335407RecruitingPhase 1
Testing a new under-the-tongue med for alcohol use and trauma
This study tests a new sublingual (under-the-tongue) medication for people with alcohol use disorder who have also had a traumatic life event. It aims to see if the medication can help reduce drinking and related symptoms.
West Haven, ConnecticutAges 21–65 - NCT05964010Recruiting
Parent-and-teen program for teen health visits
This trial offers a structured support program for teenagers and their primary caregiver during a primary care visit. It may help by testing an approach that connects youth and families with resources and support starting at the clinic visit.
New York, New YorkAges 12–17 - NCT07707115Recruiting
Simulation training for resilience and empathy in birth care
This trial tests a simulation program to improve resilience and empathy among healthcare workers who interact with birthing individuals at the University of Utah Hospital. It may help you better cope with stress and connect with patients.
Salt Lake City, UtahAges 18 years+ - NCT07741825Recruiting
Mindfulness training to prevent relapse for peer support workers
This study tests a mindfulness-based program to help people who work as peer support specialists in substance use recovery reduce their risk of relapse. It may help you manage cravings and stay healthy in your role.
Austin, TexasAges 18–100 - NCT07178158Recruiting
Extra education via app for addiction treatment
This trial tests a smartphone app called NIPA that provides extra education and support for people already taking medication for opioid or stimulant use disorder. It aims to improve addiction treatment by helping you learn more and stay on track.
Richmond, VirginiaAges 18–65 - NCT06206161Enrolling by invitation
School-based health screening study
This study tests a school program that asks students about their health habits and offers support. It is designed for high school students who are scheduled for this check-in.
Boston, MassachusettsAges 14–19 - NCT05812131Recruiting
Online training for behavioral health providers
This study tests an online training program for providers to help patients cope. If you are a behavioral health provider, you may learn new skills to support your patients.
Charleston, South CarolinaAges 18 years+ - NCT06810973Enrolling by invitation
HIV and Substance Use Support for People Leaving Jail
This study helps people with HIV or high risk of HIV who have had substance use problems and are in jail or recently released. It tests a program called SUCCESS-E to support health and reduce drug use.
Atlanta, GeorgiaAges 18 years+ - NCT05994612Recruiting
Suicide prevention for homeless youth using substances
This trial tests a program to help reduce suicide risk in young people who are homeless and use alcohol or drugs. It may provide support and strategies to keep them safe.
Columbus, OhioAges 15–24 - NCT07742722Recruiting
Peer support for veterans with mental health and substance use issues
This study tests a program where trained peer supporters help veterans who have been involved with the justice system and have mental health or substance use issues. It aims to improve their well-being and recovery.
Bedford, MassachusettsAges 18 years+ - NCT07219056Recruiting
Sound therapy for adults with trauma and addiction
This trial tests a sound-based program (Safe & Sound Protocol) to help adults with both trauma and substance use disorder in residential treatment. It aims to see if this gentle listening therapy can calm the nervous system and support recovery.
Wernersville, PennsylvaniaAges 18–75 - NCT07740395Recruiting
Support app for people in recovery and their loved ones
This study tests a support app (KulaMind-Recovery) that helps people in recovery stay connected with a loved one. You and someone important to you would both use the app to see if it helps your recovery journey.
Providence, Rhode IslandAges 18 years+ - NCT06875323Enrolling by invitation
Online program to help foster youth and CASA advocates
This study is testing a new online program to help foster youth and their CASA volunteers communicate better. If you join, you'll use a website or app to share updates and stay connected with your advocate.
San Francisco, CaliforniaAges 13–20
Hear when a new Substance Use trial opens
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 220 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.