Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07433985Recruiting
California mobile app study for men after jail release
This study tests a mobile app to help men recently released from jail or prison who use drugs or have sex with men stay healthy and avoid HIV. It's for people who don't have HIV and live in certain California counties.
Oakland, CaliforniaAges 18–59 - NCT07387796Recruiting
Brain and behavior changes with tirzepatide stop and restart
This study looks at how your brain and behavior change when you stop and then restart the weight loss drug tirzepatide. It will help researchers understand what happens during treatment breaks.
Dallas, TexasAges 18–70 - NCT07378254Recruiting
Emotional strength program for Black young adults
This study tests a program designed to help Black young adults build emotional strength after a traumatic experience. It aims to see if the program can improve well-being and resilience.
Piscataway, New JerseyAges 18–35 - NCT07365293Recruiting
Support for Families Affected by Opioid or Meth Use
This study tests a program that helps parents who are using opioids or methamphetamines get support for themselves and their families. It may be a good fit if you have Medicaid, live in certain counties, and are open to working with a coach.
Eugene, OregonAges Any age - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07303608Recruiting
Tracking progress in social services to improve outcomes
This study looks at whether regularly checking in on your progress and giving feedback to your social worker can help improve the support you receive. If you are getting help from social services, you may be able to take part.
LinköpingAges 15 years+ - NCT07223398Recruiting
Making HIV care decisions with people who've been in the justice system
This trial helps people recently involved with the justice system and who use stimulants or opioids decide on HIV prevention or treatment. It tests a shared decision-making approach for taking HIV medication (ART) or PrEP.
New Haven, ConnecticutAges 18 years+ - NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07219056Recruiting
Sound therapy for adults with trauma and addiction
This trial tests a sound-based program (Safe & Sound Protocol) to help adults with both trauma and substance use disorder in residential treatment. It aims to see if this gentle listening therapy can calm the nervous system and support recovery.
Wernersville, PennsylvaniaAges 18–75 - NCT07193914Recruiting
Program for people with addiction and trauma
This trial tests a program called ECCCLORE to help people who struggle with both addiction and trauma. It aims to see if the program can improve their well-being.
Nîmes, NîmesAges 18 years+ - NCT07178158Recruiting
Extra education via app for addiction treatment
This trial tests a smartphone app called NIPA that provides extra education and support for people already taking medication for opioid or stimulant use disorder. It aims to improve addiction treatment by helping you learn more and stay on track.
Richmond, VirginiaAges 18–65 - NCT07168642Recruiting
Study of MIO for mothers in substance use treatment
This trial tests a program called MIO to help mothers recovering from substance use disorders bond with their young children. It looks at how well the program works and how it can be put into practice.
Springfield, MassachusettsAges 18 years+ - NCT07146633Recruiting
Testing an EMDR app for PTSD and substance use
This study tests an app that uses EMDR therapy to help people with both PTSD and substance use problems. EMDR is a type of therapy that uses eye movements or taps to help process traumatic memories. You would use the app at home and avoid starting other new therapies during the study.
Toronto, OntarioAges 18 years+ - NCT07130500Enrolling by invitation
Rewards for sticking with long-acting injections
This study tests whether offering small rewards (like gift cards) can help people stick with a long-acting injection of their medication. It's for people with serious mental health conditions who have had a recent hospital stay or are at high risk of one.
Pittsburgh, PennsylvaniaAges 18–65 - NCT07097376Recruiting
Job counseling for veterans with mental health and substance use issues
This trial tests a vocational counseling program to help unemployed veterans with mental health or substance use disorders find and keep meaningful paid work. You'll meet weekly with a counselor to build skills and support your return to employment.
Hines, IllinoisAges 18 years+ - NCT07104396Recruiting
Study on developing digital treatments for addiction
This trial is looking for experienced scientists (with a PhD or MD) who study substance use disorders and are interested in testing or developing new digital treatments (like apps or computer programs). It's a chance to help create better digital tools for addiction recovery.
Hanover, New HampshireAges 18 years+ - NCT07094061Recruiting
Brain response to reward cues in young adults
This study looks at how the brain reacts to cues that signal rewards in young adults ages 18 to 22. Participants will do computer tasks and have an MRI scan to understand differences in how people respond to reward-related signals.
Ann Arbor, MichiganAges 18–22 - NCT06978452Recruiting
Youth mental health: tracking development and outcomes
This study looks at how young people's mental health develops over time. It compares youth who have already sought help for mental health concerns with those who haven't, to better understand what helps or hinders well-being.
Montreal, QuebecAges 9–25 - NCT07075081RecruitingPhase 2
Cultural healing trial for Ojibwe adults using substances
This trial tests a culturally-based program called Gii'Igoshimong (Sitting With Your First Family) for Ojibwe/Anishinaabe/Chippewa adults who have used substances recently. It aims to support wellness and recovery in a way that respects your heritage.
Duluth, MinnesotaAges 18 years+ - NCT07025083Recruiting
Parenting program for Latinx families of teens
This study is testing an online program to help parents connect better with their pre-teen or young teen. It is designed for Spanish-speaking Latinx parents and their children ages 11 to 14.
Eugene, OregonAges 11–14 - NCT07030192Recruiting
Peer Support Workers Study for Emergency Patients
This study looks at whether it is possible to offer peer support workers (people with lived experience of substance use) to patients in the Emergency Department at Vancouver General Hospital. The goal is to see if patients find this helpful and if it can improve their experience and well-being.
Vancouver, British ColumbiaAges 18 years+ - NCT07028983Recruiting
Music therapy for drug and alcohol addiction recovery
This trial tests if adding music therapy to standard addiction treatment helps people recover from substance use disorders. It is for adults who have completed detox and are not currently going through detox.
ViennaAges 18 years+ - NCT07021352Recruiting
Ear acupuncture for emotional distress in military with PTSD
This trial tests whether ear acupuncture can help active-duty service members and veterans who have emotional distress related to PTSD. You will also receive mindfulness therapy as part of the study.
Fairfield, CaliforniaAges 18–65 - NCT06981351Recruiting
Matching addiction treatment to thinking skills in prison
This trial tests whether matching treatment to specific thinking and learning problems can help people in prison who have struggled with drugs or alcohol. If you join, you may get a program designed just for your needs.
Albuquerque, New MexicoAges 18–55
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.