Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 220 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06559774Recruiting
Strong Man program for American Indian men with substance use
This study tests a program called Strong Man, which is designed to help American Indian men who have used alcohol or drugs. The program aims to support their health and well-being. If you join, you will take part in sessions and assessments to see if the program helps.
Chinle, ArizonaAges 18 years+ - NCT07168642Recruiting
Study of MIO for mothers in substance use treatment
This trial tests a program called MIO to help mothers recovering from substance use disorders bond with their young children. It looks at how well the program works and how it can be put into practice.
Springfield, MassachusettsAges 18 years+ - NCT06747442Recruiting
Native moms' recovery program during pregnancy
This study offers support for Native American and Alaska Native pregnant women who want recovery from substance use. The program connects you with your culture and community to help you and your baby.
Salt Lake City, UtahAges 18 years+ - NCT06738953Recruiting
Preventing mental disorders with a self-efficacy course
This trial tests if a course designed to boost your belief in your own abilities can help prevent anxiety, mood, or substance use disorders. It is for young adults who currently feel less confident in handling challenges.
Potsdam, BrandenburgAges 18–30 - NCT06785311Recruiting
Native Spirit After-School Program for Native Teens
This study is for Native American teens in grades 7–12 who are members of two specific Arizona tribes and already attend after-school programs. It tests a program called Native Spirit to see how it supports well-being and cultural connection.
Scottsdale, ArizonaAges 12–17 - NCT06822569Recruiting
Teen health choices & wellness study
This study tests a program to help teenagers make healthy choices. It may be a good fit if you've recently done a behavior you'd like to change and live in Rhode Island.
Providence, Rhode IslandAges 13–16 - NCT06837311Recruiting
Smoking cessation after stroke via smartphone monitoring
This study tests a smartphone-based program that helps people who recently had a stroke quit smoking. It uses digital monitoring and support as part of your regular post-stroke follow-up to lower the risk of another stroke.
BordeauxAges 18–80 - NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Birmingham, AlabamaAges 18 years+ - NCT06889831Recruiting
Paths to sexual health and recovery for women in the justice system
This study tests a program to help women with substance use and unmet contraception needs who have been involved with the criminal legal system in the past year. The goal is to see if the program supports both recovery and family planning choices.
Teaneck, New JerseyAges 18–44 - NCT06968832Recruiting
Prolonged therapy for PTSD and substance use
This trial tests a therapy that helps people with both post-traumatic stress disorder (PTSD) and a substance use disorder (SUD). You'll receive extended therapy sessions to reduce PTSD symptoms and support your recovery from substance use, while continuing your current substance use treatment.
Jacksonville, FloridaAges 18 years+ - NCT06978452Recruiting
Youth mental health: tracking development and outcomes
This study looks at how young people's mental health develops over time. It compares youth who have already sought help for mental health concerns with those who haven't, to better understand what helps or hinders well-being.
Montreal, QuebecAges 9–25 - NCT06981351Recruiting
Matching addiction treatment to thinking skills in prison
This trial tests whether matching treatment to specific thinking and learning problems can help people in prison who have struggled with drugs or alcohol. If you join, you may get a program designed just for your needs.
Albuquerque, New MexicoAges 18–55 - NCT07021352Recruiting
Ear acupuncture for emotional distress in military with PTSD
This trial tests whether ear acupuncture can help active-duty service members and veterans who have emotional distress related to PTSD. You will also receive mindfulness therapy as part of the study.
Fairfield, CaliforniaAges 18–65 - NCT07025083Recruiting
Parenting program for Latinx families of teens
This study is testing an online program to help parents connect better with their pre-teen or young teen. It is designed for Spanish-speaking Latinx parents and their children ages 11 to 14.
Eugene, OregonAges 11–14 - NCT07028983Recruiting
Music therapy for drug and alcohol addiction recovery
This trial tests if adding music therapy to standard addiction treatment helps people recover from substance use disorders. It is for adults who have completed detox and are not currently going through detox.
ViennaAges 18 years+ - NCT07030192Recruiting
Peer Support Workers Study for Emergency Patients
This study looks at whether it is possible to offer peer support workers (people with lived experience of substance use) to patients in the Emergency Department at Vancouver General Hospital. The goal is to see if patients find this helpful and if it can improve their experience and well-being.
Vancouver, British ColumbiaAges 18 years+ - NCT07075081RecruitingPhase 2
Cultural healing trial for Ojibwe adults using substances
This trial tests a culturally-based program called Gii'Igoshimong (Sitting With Your First Family) for Ojibwe/Anishinaabe/Chippewa adults who have used substances recently. It aims to support wellness and recovery in a way that respects your heritage.
Duluth, MinnesotaAges 18 years+ - NCT07094061Recruiting
Brain response to reward cues in young adults
This study looks at how the brain reacts to cues that signal rewards in young adults ages 18 to 22. Participants will do computer tasks and have an MRI scan to understand differences in how people respond to reward-related signals.
Ann Arbor, MichiganAges 18–22 - NCT07146633Recruiting
Testing an EMDR app for PTSD and substance use
This study tests an app that uses EMDR therapy to help people with both PTSD and substance use problems. EMDR is a type of therapy that uses eye movements or taps to help process traumatic memories. You would use the app at home and avoid starting other new therapies during the study.
Toronto, OntarioAges 18 years+ - NCT07193914Recruiting
Program for people with addiction and trauma
This trial tests a program called ECCCLORE to help people who struggle with both addiction and trauma. It aims to see if the program can improve their well-being.
Nîmes, NîmesAges 18 years+ - NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07223398Recruiting
Making HIV care decisions with people who've been in the justice system
This trial helps people recently involved with the justice system and who use stimulants or opioids decide on HIV prevention or treatment. It tests a shared decision-making approach for taking HIV medication (ART) or PrEP.
New Haven, ConnecticutAges 18 years+ - NCT07303608Recruiting
Tracking progress in social services to improve outcomes
This study looks at whether regularly checking in on your progress and giving feedback to your social worker can help improve the support you receive. If you are getting help from social services, you may be able to take part.
LinköpingAges 15 years+ - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 220 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.