Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06968832Recruiting
Prolonged therapy for PTSD and substance use
This trial tests a therapy that helps people with both post-traumatic stress disorder (PTSD) and a substance use disorder (SUD). You'll receive extended therapy sessions to reduce PTSD symptoms and support your recovery from substance use, while continuing your current substance use treatment.
Jacksonville, FloridaAges 18 years+ - NCT06889831Recruiting
Paths to sexual health and recovery for women in the justice system
This study tests a program to help women with substance use and unmet contraception needs who have been involved with the criminal legal system in the past year. The goal is to see if the program supports both recovery and family planning choices.
Teaneck, New JerseyAges 18–44 - NCT06875323Enrolling by invitation
Online program to help foster youth and CASA advocates
This study is testing a new online program to help foster youth and their CASA volunteers communicate better. If you join, you'll use a website or app to share updates and stay connected with your advocate.
San Francisco, CaliforniaAges 13–20 - NCT06863909Enrolling by invitation
Journaling plus cognitive behavioral therapy for better results
This trial explores whether adding journaling to your regular cognitive behavioral therapy sessions helps you feel better more quickly. You keep seeing your therapist as usual, just add a few minutes of writing each day.
TübingenAges 18–65 - NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Birmingham, AlabamaAges 18 years+ - NCT06837311Recruiting
Smoking cessation after stroke via smartphone monitoring
This study tests a smartphone-based program that helps people who recently had a stroke quit smoking. It uses digital monitoring and support as part of your regular post-stroke follow-up to lower the risk of another stroke.
BordeauxAges 18–80 - NCT06822569Recruiting
Teen health choices & wellness study
This study tests a program to help teenagers make healthy choices. It may be a good fit if you've recently done a behavior you'd like to change and live in Rhode Island.
Providence, Rhode IslandAges 13–16 - NCT06810973Enrolling by invitation
HIV and Substance Use Support for People Leaving Jail
This study helps people with HIV or high risk of HIV who have had substance use problems and are in jail or recently released. It tests a program called SUCCESS-E to support health and reduce drug use.
Atlanta, GeorgiaAges 18 years+ - NCT06785311Recruiting
Native Spirit After-School Program for Native Teens
This study is for Native American teens in grades 7–12 who are members of two specific Arizona tribes and already attend after-school programs. It tests a program called Native Spirit to see how it supports well-being and cultural connection.
Scottsdale, ArizonaAges 12–17 - NCT06747442Recruiting
Native moms' recovery program during pregnancy
This study offers support for Native American and Alaska Native pregnant women who want recovery from substance use. The program connects you with your culture and community to help you and your baby.
Salt Lake City, UtahAges 18 years+ - NCT05563363Recruiting
Home-based treatment for severe addiction problems
This trial tests a home-based treatment approach for adults with severe substance use problems. It may help you and your care team manage addiction with structured support while you stay at home.
GenevaAges 18 years+ - NCT06559774Recruiting
Strong Man program for American Indian men with substance use
This study tests a program called Strong Man, which is designed to help American Indian men who have used alcohol or drugs. The program aims to support their health and well-being. If you join, you will take part in sessions and assessments to see if the program helps.
Chinle, ArizonaAges 18 years+ - NCT06526143Recruiting
Pain care pathway for recent veterans
This study tests a new approach to help veterans manage pain in their back, neck, knee, or shoulder after leaving the military. It includes phone or online check-ins and support tailored to your needs.
West Haven, ConnecticutAges 18 years+ - NCT06477588Recruiting
HIV services and job help for justice-involved Black men
This study helps Black men who have sex with men or other key populations who have been involved with the justice system get HIV services and job support. It aims to connect you to care and employment help, especially if you aren't already receiving HIV or PrEP care.
Chicago, IllinoisAges 18 years+ - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT06324318RecruitingPhase 2
Parenting program for American Indian families in cities
This study tests a parenting program for American Indian parents and their children aged 12-17 who live in cities. It aims to help families strengthen their connections and support healthy development.
Phoenix, ArizonaAges 12 years+ - NCT06216600Recruiting
Women's strength and resilience program for HIV and substance use
This study tests a program for women living with HIV who also struggle with substance use or heavy drinking. It combines exercise and support to help build strength and resilience. You may qualify if you've missed some HIV medications, have a detectable viral load, and have experienced violence.
San Diego, CaliforniaAges 18 years+ - NCT06206161Enrolling by invitation
School-based health screening study
This study tests a school program that asks students about their health habits and offers support. It is designed for high school students who are scheduled for this check-in.
Boston, MassachusettsAges 14–19 - NCT06115746Recruiting
A drug education program for middle and high school students
This study tests a program called iDECIDE, which helps students who have had a substance use issue at school. The program aims to provide education and support instead of punishment. Participants will attend up to 9 online study visits over about a year.
Boston, MassachusettsAges 9–22 - NCT05994612Recruiting
Suicide prevention for homeless youth using substances
This trial tests a program to help reduce suicide risk in young people who are homeless and use alcohol or drugs. It may provide support and strategies to keep them safe.
Columbus, OhioAges 15–24 - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT05816083Recruiting
Virtual reality tool for teens and young adults after trauma
This study tests a virtual reality program to help young people who have been through serious violence or sexual assault (“ITE”). It’s also open to certain healthcare workers who support these young people.
Charleston, South CarolinaAges 15–30 - NCT05812131Recruiting
Online training for behavioral health providers
This study tests an online training program for providers to help patients cope. If you are a behavioral health provider, you may learn new skills to support your patients.
Charleston, South CarolinaAges 18 years+ - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.