Clinical trials
Temporomandibular Disorder clinical trials
Below are recruiting temporomandibular disorder clinical trials, each written for real people, not researchers. We’re tracking 75 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05006963Recruiting
Tele-rehab for jaw pain from TMJ problems
This trial tests a remote (telehealth) rehabilitation program to help reduce pain caused by temporomandibular joint (jaw joint) problems. It may help you if you’ve had facial/jaw-related pain for months and have a related diagnosis.
São PauloAges 18–60 - NCT05167656Recruiting
Manual therapy for one-sided jaw pain
This study compares two types of hand-based therapy to see which helps people with jaw (temple/ear-area) pain on one side. You may be eligible if your jaw pain has lasted more than a month and you have not had recent jaw-related treatment or procedures.
Alcalá de Henares, MadridAges 18–75 - NCT06186830Recruiting
Questionnaire for jaw and face pain
This study tests a special questionnaire (BETY-BQ) to see how well it measures the impact of jaw and face pain in people with temporomandibular disorders. It helps doctors better understand your symptoms and guide treatment.
Karabük, Karabük ProvinceAges 18–64 - NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT05214924Enrolling by invitationPhase 2/Phase 3
PRF injections for mild to moderate jaw joint wear
This study tests whether injecting iPRF (a therapy made from your blood growth factors) into the jaw joint can reduce symptoms from mild to moderate jaw joint degeneration. It’s being compared against standard care for people who currently are not on other jaw-joint treatments.
WroclawAges 18–80 - NCT06500390Recruiting
TMD and levonorgestrel IUD use study
This study looks at whether using a levonorgestrel intrauterine device (a hormone-releasing IUD) for at least 3 months is linked to jaw joint problems (temporomandibular disorder). It may help women understand potential side effects of this birth control method.
Istanbul, MaltepeAges 18–45 - NCT06602375Recruiting
Physical therapy and exercise for jaw pain
This study tests if adding manual physical therapy and exercise to standard dental care helps active-duty service members with jaw pain (temporomandibular disorders). It aims to see if this combination works better than dental care alone.
Fort Sam Houston, TexasAges 18–55 - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06975709Recruiting
Link between jaw pain and sleep problems
This study looks at how jaw joint disorders (TMJ) are related to sleep issues like insomnia, sleep apnea, or restless legs. If you have a sleep disorder, you may help researchers understand the connection.
Milan, ItalyAges 18 years+ - NCT00932594Recruiting
New treatment approach for jaw joint problems
This trial studies a “serial” (step-by-step) treatment plan for temporomandibular disorders (TMJ), which can cause pain, clicking, and trouble opening your mouth. It may help by improving how your jaw joint moves and reducing symptoms.
Guangzhou, GuangdongAges 16–60 - NCT07474662Recruiting
Online vs. in-person physiotherapy for jaw muscle pain
This trial compares online physiotherapy sessions with face-to-face visits to see which works better for treating jaw muscle pain (myalgia). It aims to find a more convenient way to get care for this common condition.
Budapest, Pest CountyAges 18 years+ - NCT07507734Recruiting
Splint and exercise therapy for jaw joint pain
This trial tests whether a custom mouth splint combined with jaw exercises can reduce pain in the jaw joint (TMJ). It may help people who have had jaw joint pain for at least 3 months.
Istanbul, TuzlaAges 18–65 - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Ridgeland, MississippiAges 12 years+ - NCT07666360Recruiting
Jaw pain study: factors that predict TMD severity
This trial looks at how your head, neck, and jaw work together to understand why some people have more severe jaw joint (TMD) pain. If you have jaw pain, the findings may help researchers identify better treatments.
AnkaraAges 18–55 - NCT07566936Enrolling by invitation
Digital vs. Traditional Splints for Jaw Joint Disorders
This study compares two types of custom-made jaw splints—one designed using digital technology and one made the traditional way—to see which better relieves jaw pain and improves mouth opening in people with temporomandibular disorder (TMD), a common condition affecting the jaw joint.
Islamabad, IslamabadAges 18–40 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT06813040Recruiting
TMS therapy for jaw and face pain
This trial tests if repetitive transcranial magnetic stimulation (a non-invasive brain stimulation technique) can reduce long-lasting jaw and face pain caused by temporomandibular disorders. It might help people who have had pain for over six months and rate their pain as high.
CoimbraAges 18 years+ - NCT06874868Recruiting
Saliva stress test for jaw pain disorder
This study measures cortisol levels in your saliva to see if it can help diagnose temporomandibular disorder (jaw pain). It aims to find a simple way to better understand this condition.
Coimbra, Coimbra DistrictAges 18 years+ - NCT07018791RecruitingPhase 3
Art-based pain test for jaw joint disorder patients
This trial tests if using art can help measure pain in people with temporomandibular joint disorders (TMD). It may offer a new way to understand and manage your pain without surgery.
Jeddah, Mecca RegionAges 18 years+ - NCT07147764Recruiting
Pain education plus physiotherapy for jaw pain
This trial compares two treatments for long-lasting jaw or face pain: physiotherapy alone versus physiotherapy combined with education about how pain works. It aims to find which approach helps more.
Istanbul, KavacikAges 18–65 - NCT06912438Enrolling by invitation
Emotional release after dry needling for jaw and head pain
This study tests whether a dry needling technique (trigger point needling) can help release emotional tension and reduce pain from muscle knots in the head and neck. It may be a good option if you have jaw or headache pain related to muscle tightness.
Tel Aviv, IsraelAges 18 years+ - NCT07273123Recruiting
Chewing gum and fatigue in jaw joint health
This study tests if chewing sugar-free gum for a while can affect how tired you feel and how your jaw muscles work. It compares people with and without jaw joint problems (TMJ disorders).
Milan, MilanAges 19–35 - NCT07317570Recruiting
Body awareness therapy for jaw pain and function
This study tests whether body awareness therapy (gentle exercises that help you notice how your body moves and feels) can reduce jaw pain, improve function, and help with related emotional stress. It is for people with long-term jaw joint problems.
RizeAges 18 years+
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Common questions
- Are there clinical trials for temporomandibular disorder?
- Yes. Clin2 currently lists 75 recruiting temporomandibular disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a temporomandibular disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a temporomandibular disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Temporomandibular Disorders (TMD)
- Temporomandibular Joint Disorders
- Temporomandibular Disorders (TMDs)
- Temporomandibular Joint Dysfunction
- Temporomandibular Joint Dysfunction Syndrome
- Temporomandibular Dysfunction (TMD)
- Temporomandibular Joint Disc Displacement, Without Reduction
- Temporomandibular Joint and Muscle Disorder
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.