Clinical trials
Tobacco Use Cessation clinical trials
Below are recruiting tobacco use cessation clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06483412Enrolling by invitation
Healthy Futures: A Vaping Intervention for Teens
This study is testing a program called Healthy Futures that schools can use instead of suspending students caught vaping. The trial wants to see if the program helps teens quit vaping.
Palo Alto, CaliforniaAges 14–18 - NCT07292883RecruitingPhase 2
Accelerated TMS for smoking cessation
This trial tests whether a rapid form of brain stimulation (TMS) can help people stop smoking. It is designed for adults who are ready to quit within the next month.
Penetanguishene, OntarioAges 18 years+ - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT05863923Enrolling by invitation
Text message program to help people with HIV quit smoking
This study tests a texting program that sends messages to help people living with HIV who smoke quit smoking. It may help you reduce tobacco use using regular, motivational text messages.
Worcester, MassachusettsAges 18 years+ - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT07049757Recruiting
Healthy Family Project: Reducing tobacco smoke in Chinese American homes
This study helps Chinese American families reduce tobacco use and secondhand smoke exposure. Smokers, family members, and community health workers are all welcome.
San Francisco, CaliforniaAges 18 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT07447635Recruiting
Testing a program to help cancer survivors quit smoking and reduce drinking
This study tests a program (MBI) to help cancer survivors quit smoking and cut back on alcohol. It's designed for people who want to make these changes in the next 30 days.
Tampa, FloridaAges 18 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06405074Recruiting
Ultrasound for Smoking Cessation in Veterans
This study tests if a gentle ultrasound aimed at a specific part of the brain (the insula) can help veterans who smoke tobacco reduce or quit smoking. The research is for veterans who smoke heavily and are motivated to think about quitting but are not currently in treatment.
Washington D.C., District of ColumbiaAges 18–75 - NCT05786547RecruitingPhase 3
Varenicline plus support to help quit tobacco in HIV care
This Phase 3 trial tests a quit-smoking program using varenicline (a medicine) plus additional support, for people with HIV who currently use tobacco. It may help you stop smoking or using tobacco and stay quit with safer, guided care.
Aurora, ColoradoAges 18 years+ - NCT07132814Recruiting
Testing abuse potential of five oral nicotine products
This study tests how much people might want to use five different types of modern oral nicotine products (like pouches or lozenges) compared to smoking their usual cigarette. It helps researchers understand if these products could be less addictive than cigarettes.
Overland Park, KansasAges 21–60 - NCT06239350Recruiting
Young adult tobacco and cannabis co-use study
This study tests a program to help young adults who use both nicotine and cannabis products reduce or quit nicotine use. If you are between 18 and 25, use nicotine products at least 20 days a month and cannabis at least 10 days a month, and want to quit nicotine, you may be eligible.
Charleston, South CarolinaAges 18–25 - NCT06033599RecruitingPhase 3
Mindfulness and motivation to quit smoking while on methadone
This study combines counseling (motivational interviewing) with mindfulness training (like guided exercises) to help people on methadone quit smoking. It tests if adding mindfulness can make it easier to stop smoking and stay quit.
New Brunswick, New JerseyAges 18 years+ - NCT06922617Recruiting
Comparing e-cigarettes to standard quitting aids for people in addiction treatment
This study compares two ways to help people who are in treatment for substance use also quit or reduce smoking: using e-cigarettes or using standard nicotine replacement therapy (like patches or gum). If you're ready to make a change in your smoking, this could be a helpful option.
Charleston, South CarolinaAges 21 years+ - NCT06432985Recruiting
Smoking cessation coaching for veterans with cancer
This study tests a counseling program to help veterans who smoke quit smoking, especially those undergoing cancer treatment or lung cancer screening. It may improve health outcomes during cancer care.
San Francisco, CaliforniaAges 18 years+ - NCT07812753Recruiting
Brain stimulation for smoking cessation
This study looks at how a non-invasive brain stimulation technique called TMS (which uses magnetic pulses to stimulate the brain) might affect the brain's reward system in people who smoke. The goal is to understand how to help people quit smoking more effectively.
Newark, New JerseyAges 18–60 - NCT06966362RecruitingPhase 4
Help cutting back on smoking for veterans not ready to quit
This study tests a medicine called varenicline (also known as Chantix) to help veterans who aren't ready to quit smoking yet but want to cut down. The goal is to see if it helps reduce how much they smoke.
San Diego, CaliforniaAges 21 years+ - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75
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Common questions
- Are there clinical trials for tobacco use cessation?
- Yes. Clin2 currently lists 95 recruiting tobacco use cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.