Clinical trials
Tobacco Use Cessation clinical trials
Below are recruiting tobacco use cessation clinical trials, each written for real people, not researchers. We’re tracking 104 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06922617Recruiting
E-cigarettes vs. Nicotine Replacement for Smoking in Substance Use Treatment
This study compares e-cigarettes to nicotine replacement therapy (like patches or gum) to help people who are in treatment for substance use disorder (like drugs or alcohol) quit or reduce smoking. It aims to find a safer way to cut back on cigarettes.
Charleston, South CarolinaAges 21 years+ - NCT06432985Recruiting
Smoking Cessation Program for Veterans with Cancer
This study tests a video-based program to help Veterans who smoke and are being treated for cancer or lung cancer screening to quit. If you're a VA patient in San Francisco and currently smoke, you may be able to join.
San Francisco, CaliforniaAges 18 years+ - NCT06451081Recruiting
Helping Hong Kong smokers quit with a text-based program
This study tests a new program that uses text messages to help people who smoke daily to quit. It is designed for Hong Kong residents who can read Chinese and own a smartphone.
Hong KongAges 18 years+ - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07571018Recruiting
Mobile app to help young adults quit tobacco
This study tests a new smartphone app designed to help people aged 18–30 quit tobacco and nicotine products. Researchers want to learn if the app works and how to improve it based on your feedback and daily experiences.
Las Cruces, New MexicoAges 18–30 - NCT05672914Recruiting
Help quitting smoking after a psychiatric hospital stay
This study tests a program meant to help people stop smoking after they leave a psychiatric hospital. It may help you stay smoke-free longer by offering structured support during a high-risk time.
Austin, TexasAges 18 years+ - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06762210Recruiting
Quit smoking with AI and dental health checks
This trial tests whether a smartphone app that uses artificial intelligence (AI) can help you quit smoking by looking at how it affects your dental health. If you smoke at least 5 cigarettes a day and want to quit, you may be able to join.
Fayoum, Alexandria GovernorateAges 21–65 - NCT05868421Recruiting
Veteran coaching with a trusted person to quit smoking
This study tests whether involving a supportive family member or friend can help a veteran use smoking-quit treatment more effectively. If you’ve smoked recently and can name a trusted contact who will join, you may be able to participate.
Minneapolis, MinnesotaAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT06470321Recruiting
Predictors of nicotine relapse in smokers
This study looks at factors that might predict whether someone will start smoking again after quitting. It is for adults who smoke daily, want to quit, and are not on any medications.
NicosiaAges 18–60 - NCT07162935Recruiting
Cigarillo use study for young adults
This study looks at how young adults use cigarillos. You will smoke research cigarillos in a lab and answer questions. The goal is to understand cigarillo use to help with future regulation.
Oklahoma City, OklahomaAges 18–24 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT06249984Recruiting
Comparing moist snuff products for adult users in rural areas
This study compares different types of moist snuff to understand how they affect users. It may help find ways to reduce harm for people who use smokeless tobacco.
Columbus, OhioAges 21 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07402642Recruiting
Early Education to Lower Heart Attack Risk Factors
This trial tests if personalized education after a heart attack helps patients lower their future risk of heart problems. It focuses on people who had an emergency procedure to open blocked arteries.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT06901713Recruiting
Help quitting smoking with CBT and mindfulness
This trial tests a smoking cessation program that combines cognitive behavioral therapy (CBT) and mindfulness audio to help you quit or reduce smoking. You'll receive digital materials to support you.
HangzhouAges 18–65 - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT06566703Recruiting
Testing a program to help quit smoking in tribal communities
This study tests a program called ANSOS to help people who smoke and are American Indian quit. You'd take part in Zoom sessions and be in the study for one year to see how well the program works.
Bethlehem, PennsylvaniaAges 18 years+ - NCT06310187Recruiting
Little cigar study for daily cigarette smokers
This study looks at how certain chemicals from little cigars affect the body. It may help researchers understand health risks. You must be a daily cigarette smoker who has never smoked little cigars.
Hershey, PennsylvaniaAges 21–65
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Common questions
- Are there clinical trials for tobacco use cessation?
- Yes. Clin2 currently lists 104 recruiting tobacco use cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.