Clinical trials
Tobacco clinical trials
Below are recruiting tobacco clinical trials, each written for real people, not researchers. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT06651684Recruiting
Quit smoking help for parents with social needs
This trial tests if health navigators can help parents who smoke and have unmet social needs to quit smoking. If you smoke and face challenges like trouble paying bills or finding childcare, this program may support you.
Montreal, QuebecAges 18 years+ - NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT03713424RecruitingPhase 2
Brain scan study of an antibiotic for drug addiction
This study uses an MRI brain scan to see how taking clavulanic acid affects brain activity related to drug addiction. It may help researchers understand whether this medicine could change how addiction-related cues affect the brain.
Columbia, MissouriAges 18–65 - NCT03912194RecruitingPhase 3
Training to help you quit smoking sooner and feel better
This Phase 3 study tests a quit-training program that teaches how to handle urges and negative feelings when you start cutting back or stopping smoking. You may benefit by improving your chances of quitting and reducing stress during withdrawal.
Birmingham, AlabamaAges 18 years+ - NCT03948893Recruiting
Behavior program to help you quit nicotine
This study tests a structured counseling/behavior treatment to help people who smoke become nicotine-free. If you’re interested in quitting, you may be asked to complete questionnaires and follow a quit plan as part of the research.
Columbia, MissouriAges 18 years+ - NCT04595422Recruiting
Train quitline staff to reach smokers about lung screening
This trial tests an educational approach delivered through tobacco quitlines to encourage eligible smokers to learn about lung cancer screening. It may help people who have a heavy smoking history get the right information and next steps.
Houston, TexasAges 18 years+ - NCT04715568RecruitingPhase 4
Testing how smoke exposure affects heart health
This study looks at whether being exposed to secondhand tobacco smoke at work affects heart and blood vessel health. It may help researchers understand which people are at higher risk and how the body responds to that exposure.
San Francisco, CaliforniaAges 40 years+ - NCT04722835Recruiting
Study lung immune cells in people at risk for COPD
This study looks at different lung immune cell patterns and how they work in smokers who are not yet diagnosed with COPD or asthma. It may help researchers understand why some people are more likely to develop COPD, which could guide future prevention or early treatments.
San Francisco, CaliforniaAges 40–75 - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT05019495Recruiting
Study to improve quit-smoking support for people with HIV
This trial tests ways to deliver tobacco-quit treatment more effectively for people living with HIV. You may help researchers compare different quit-support approaches to see what works best.
Charleston, South CarolinaAges 21 years+ - NCT05338801Recruiting
Study menthol effects in e-cigarette users
This study tests how menthol in e-cigarettes affects addiction-related feelings and exposure. You may be asked to visit a lab and temporarily stop vaping before each session.
Miami, FloridaAges 21–35 - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05642715Recruiting
HIV smoking reduction program with varenicline and online support
This study tests a harm-reduction approach to help people with HIV smoke fewer cigarettes and quit if they want, using an online tobacco program and varenicline (a quit-smoking medicine). You may be placed in one of two different study groups to compare how well the approaches work.
The Bronx, New YorkAges 40–79 - NCT05679349Recruiting
Help your clinic improve lung cancer screening for smokers
This study helps primary care clinics reach people who have a long smoking history so they can get lung cancer screening at the right time. It may help you (and others) get reminders and outreach to make screening easier to schedule.
Philadelphia, PennsylvaniaAges 50–77 - NCT05707871RecruitingEarly Phase 1
Testing how low-nicotine cigarettes affect heart measurements
This early study checks whether very low-nicotine cigarettes change heart-related measurements during a lab visit. It may help researchers understand how lowering nicotine could affect cardiovascular (heart and blood vessel) function.
Winston-Salem, North CarolinaAges 21 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT05814055RecruitingPhase 2
Kava to help quit smoking by easing stress and sleep issues
This Phase 2 study tests whether kava can help people quit smoking, especially by reducing stress and improving sleep during tobacco abstinence. You may be offered kava as part of a quitting support plan and monitored for safety and progress.
Gainesville, FloridaAges 21–75
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Common questions
- Are there clinical trials for tobacco?
- Yes. Clin2 currently lists 190 recruiting tobacco studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.