Clinical trials
Tobacco Smoking clinical trials
Below are recruiting tobacco smoking clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06098144RecruitingPhase 4
Smoking cessation program for construction workers
This study tests a program to help construction workers quit smoking. It involves safety managers receiving training to support workers in their quit attempts.
Miami, FloridaAges 18 years+ - NCT06535867Recruiting
Comparing phone-based vs. in-person mouth cancer screening in rural India
This study compares two ways to find early signs of mouth cancer or conditions that could lead to cancer. One method uses a simple phone-based health check, and the other uses standard in-person screening. People in rural areas of Varanasi who are at risk—such as those who use tobacco or have mouth sores—may be able to join.
New York, New YorkAges 18 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT05415371Enrolling by invitation
Smoking help program for pregnant women in Medicaid
This study tests a smoking-cessation program for pregnant people who smoke while using Medicaid. It may help reduce smoking during pregnancy through structured support calls.
Oklahoma City, OklahomaAges 18–105 - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT07132814Recruiting
Testing abuse potential of five oral nicotine products
This study tests how much people might want to use five different types of modern oral nicotine products (like pouches or lozenges) compared to smoking their usual cigarette. It helps researchers understand if these products could be less addictive than cigarettes.
Overland Park, KansasAges 21–60 - NCT06693700Recruiting
Using an air quality monitor to help make your home smoke-free
This study tests whether an indoor air quality monitor can help people keep their homes smoke-free. It is for MSK patients who currently smoke and want to reduce smoke exposure indoors.
Basking Ridge, New JerseyAges 18 years+ - NCT05445804RecruitingPhase 1
Oral cannabidiol (CBD) to help you quit tobacco
This Phase 1 study tests whether taking oral CBD can help people quit tobacco. It also checks safety and helps researchers learn how people respond to the treatment while they practice quitting.
Baltimore, MarylandAges 18–65 - NCT06881069Recruiting
Text-based tobacco cessation support for low-income Utahns
This study tests a text-message program to help people who use tobacco quit. It's designed for adults living in low-income areas in Utah who visit certain clinics.
Salt Lake City, UtahAges 18 years+ - NCT06883097Recruiting
Quitting smoking with HIV: A smoking cessation trial
This study tests whether nicotine replacement therapy (like patches or gum) can help people living with HIV quit smoking. You'll be part of a program that supports your quit attempt while you receive care for HIV.
Winston-Salem, North CarolinaAges 18 years+ - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT07553962Recruiting
How couples support each other when quitting smoking
This study looks at how couples who both smoke can help each other quit. Researchers want to understand the ways partners support one another during a smoking cessation attempt, which may help improve quit success rates.
Denver, ColoradoAges 18 years+ - NCT06042361Enrolling by invitation
Making smoke-free housing fairer for residents
This study aims to make smoke-free policies more equitable in affordable housing communities. If you live in one of the six selected properties in Massachusetts, Maryland, or New York, you may be able to participate in a survey or a group discussion.
Boston, MassachusettsAges 18 years+ - NCT06170437Recruiting
Smoke-free Home Study in Subsidized Housing
This study looks at ways to help people who live in subsidized housing make their homes smoke-free. You may be able to join if you are a current smoker and smoke inside your home.
San Francisco, CaliforniaAges 18 years+ - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT07743710Recruiting
Telehealth smoking study for chronic pain
This study tests a telehealth program to help people with chronic pain learn about smoking and pain management. It may help you understand how smoking affects your pain and explore ways to reduce smoking without quitting right away.
Binghamton, New YorkAges 18 years+ - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT05786547RecruitingPhase 3
Varenicline plus support to help quit tobacco in HIV care
This Phase 3 trial tests a quit-smoking program using varenicline (a medicine) plus additional support, for people with HIV who currently use tobacco. It may help you stop smoking or using tobacco and stay quit with safer, guided care.
Aurora, ColoradoAges 18 years+ - NCT06470321Recruiting
Predictors of nicotine relapse in smokers
This study looks at factors that might predict whether someone will start smoking again after quitting. It is for adults who smoke daily, want to quit, and are not on any medications.
NicosiaAges 18–60 - NCT06218056RecruitingPhase 2
CBD for reducing cigarette smoking in a treatment center
This study tests whether a daily dose of cannabidiol (CBD) can help people who smoke at least 5 cigarettes a day cut down or quit. It is for people staying at a treatment center in Los Angeles where cannabis use is not allowed.
North Hollywood, CaliforniaAges 18–65 - NCT07080788Recruiting
Native American Pain Risk Study: Smoking Cessation
This study looks at how quitting smoking affects pain in Native American adults. Eligible participants are daily smokers who own a smartphone and do not have heart problems or chronic pain.
Tulsa, OklahomaAges 18 years+ - NCT07049757Recruiting
Healthy Family Project: Reducing tobacco smoke in Chinese American homes
This study helps Chinese American families reduce tobacco use and secondhand smoke exposure. Smokers, family members, and community health workers are all welcome.
San Francisco, CaliforniaAges 18 years+ - NCT06254001RecruitingPhase 4
Combined tobacco treatment for hospitalized smokers
This trial tests a combination of treatments to help hospitalized smokers quit. If you are a smoker currently in the hospital, you may be able to join and get support to stop smoking.
Mexico CityAges 18 years+
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Tobacco Smoking trials by city
Studies with a site in or near these metro areas.
Tobacco Smoking trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for tobacco smoking?
- Yes. Clin2 currently lists 125 recruiting tobacco smoking studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco smoking trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco smoking trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.