Clinical trials
Transgender clinical trials
Below are recruiting transgender clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06177600Recruiting
TransHealthGUIDE: Health help for gender-diverse young adults
This study aims to improve healthcare for gender-diverse young adults (ages 18-29) and their caregivers. It involves a program to support transgender and nonbinary health and will take place online.
Boston, MassachusettsAges 18–29 - NCT05318755Recruiting
Gender-affirming hormone therapy study for adults starting care
This study looks at starting gender-affirming hormone therapy (GAHT) for transgender people who have never had these treatments before. It may help you learn whether this approach is safe and effective for your goals as you begin care.
Beijing, Beijing MunicipalityAges 18–40 - NCT06436560Enrolling by invitation
Support for transgender and non-binary people seeking vaginoplasty
This study tests a virtual peer support program for transgender and non-binary people who are planning to have vaginoplasty. It aims to see if talking with a trained peer can help with the process.
San Francisco, CaliforniaAges 18 years+ - NCT05927350Recruiting
Transgender and gender-diverse teens research participation
This study is looking for teens ages 15 to 21 who identify as transgender or gender-diverse (their gender identity is different from the sex they were assigned at birth). Your participation may help researchers better understand and support transgender and gender-diverse youth.
Richmond, VirginiaAges 15–21 - NCT06733415Enrolling by invitation
Hormone therapy and energy changes in transgender people
This study looks at how starting gender-affirming hormone therapy changes the way your body uses energy. It might help explain weight and metabolism changes some people notice during treatment.
Tel AvivAges 17 years+ - NCT06202898Recruiting
Study helping transgender women access HIV prevention (PrEP)
This study helps transgender women who are not regularly using PrEP (a daily pill to prevent HIV) get access to HIV prevention services. It uses a smartphone to take pictures and connect with support.
Orlando, FloridaAges 18 years+ - NCT06487754Recruiting
Chronic pelvic pain in trans people on testosterone therapy
This study explores why some trans masculine people develop new or worsening pelvic pain after starting testosterone therapy. Researchers want to understand your experience through interviews.
Saint-Martin-d'HèresAges 18 years+ - NCT06832514RecruitingPhase 4
Gender and immune response to meningitis B vaccine
This study tests how well the meningitis B vaccine works in transgender and cisgender people. It aims to understand if sex and gender affect immune responses.
GhentAges 18–50 - NCT06774053Recruiting
The SPECTRA study for transgender and gender diverse people
This study follows transgender and gender diverse people of all ages 16 and older to learn more about their health and well-being over time. It is for those who have a diagnosis of gender incongruence and are either starting, continuing, or have stopped gender affirming therapy.
BaselAges 16 years+ - NCT07505875Recruiting
Study to create transgender-friendly services for chemsex support
This study aims to develop healthcare services tailored to transgender people regarding chemsex (using drugs during sex). Researchers will interview participants to understand their needs and experiences.
Pathum Wan, BangkokAges 18 years+ - NCT07512856Recruiting
Support Service for Transgender People Using Substances
This study tests a new support program designed specifically for transgender people who use drugs or engage in chemsex (using drugs during sexual activity). The program aims to reduce health risks and provide safer, more culturally respectful care.
Pathum Wan, BangkokAges 18 years+ - NCT06959992Recruiting
Resilience in transgender and nonbinary people in the metaverse
This study explores how transgender and nonbinary people handle social challenges and build resilience in virtual worlds (the metaverse). It aims to understand the impact of online experiences and may help develop better support programs.
Bucharest, BucharestAges 18–35 - NCT06409975Recruiting
Self-compassion program for transgender and nonbinary young adults
This study tests an online self-compassion program designed for transgender and nonbinary young adults ages 18–29. It aims to see if the program is easy to use and helpful for reducing stress and improving emotional well-being.
Providence, Rhode IslandAges 18–29 - NCT06807580RecruitingPhase 2
Adding progesterone to gender-affirming hormone therapy: a study for transgender women
This study tests whether adding progesterone to your current hormone therapy helps transgender women feel better and more satisfied with their treatment. It might be a good fit if you've been on hormones for at least 6 months and haven't used progesterone before.
Atlanta, GeorgiaAges 18–60 - NCT06656676Recruiting
WePrEP: HIV prevention tool for transgender women
This study is creating a decision-making tool to help transgender women choose the right PrEP (HIV prevention pill) for them. It is looking for transgender women in Denver who are HIV-negative and interested in learning more about PrEP, as well as healthcare providers who help transgender women decide about PrEP.
Sheridan, ColoradoAges 18–65 - NCT06093724Recruiting
Imaging pelvic changes after gender-affirming surgery
This study uses MRI scans to see how pelvic structures change after gender-affirming vaginoplasty in transgender women. It may help improve surgical techniques and follow-up care.
Limoges, LimogesAges 18 years+ - NCT04254354Recruiting
Body identity clinic for transgender men on testosterone
This trial is for transgender men who want care focused on body identity. It likely studies how testosterone treatment and clinic support affect body-related feelings and wellbeing.
OdenseAges 18 years+ - NCT07075731Recruiting
Cervical and endometrial cancer screening before gender-affirming hysterectomy
This study looks at how to best screen for cervical and endometrial (uterine lining) cancer in transgender and gender-diverse people who have had or plan to have a hysterectomy (surgery to remove the uterus and cervix). It aims to make screening more comfortable and effective for this community.
Minneota, MinnesotaAges 18 years+ - NCT05587751Recruiting
Testing how gender-affirming care affects lung function
This study checks whether gender-affirming treatments change breathing/lung test results over time. It may help doctors understand any lung-related effects for transgender and gender-diverse people.
Rochester, MinnesotaAges 14 years+ - NCT05334888Recruiting
Study how sex and gut bacteria relate to heart risk
This study follows people over time to understand how sex-related factors and gut bacteria may affect heart and blood-vessel risk. It may help researchers identify who could benefit from earlier prevention, based on personal risk patterns.
BerlinAges 18–50 - NCT06083766Recruiting
Hormone Therapy Effects on Metabolism in Transgender Adults
This study looks at how long-term gender-affirming hormone therapy affects your body's metabolism and energy use. Researchers want to understand these changes better to improve care for transgender and gender-diverse people.
Rochester, MinnesotaAges 18–40 - NCT07509827Recruiting
App-based program to help prevent HIV and reduce stigma
This study tests a mobile health program to help young transgender women prevent HIV and cope with stigma. Participants use an app and are not yet taking PrEP daily or have trouble sticking with it.
Bangkok, BangkapiAges 18–29 - NCT06967753RecruitingPhase 4
Switching to a two-drug HIV regimen for transgender women
This trial tests if switching to a two-drug combination of dolutegravir and lamivudine is safe and effective for transgender women who already have undetectable HIV levels on a three-drug regimen. It aims to simplify treatment and reduce side effects.
Buenos Aires, Buenos Aires F.D.Ages 18 years+ - NCT05169762Recruiting
Hormone feminizing treatment for transgender and non-binary people
This study looks at feminizing gender-affirming treatment (hormones) in transgender women and non-binary people. It may help improve how this type of treatment is provided and evaluated for safety and effectiveness.
OdenseAges 18 years+
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Common questions
- Are there clinical trials for transgender?
- Yes. Clin2 currently lists 45 recruiting transgender studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transgender trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transgender trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.