Clinical trials
Transgender clinical trials
Below are recruiting transgender clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07746999Enrolling by invitation
Liver health study for transgender adults
This study looks at liver health in transgender individuals to better understand and improve care. You may join if you are 18 or older and can read and write in English.
Newark, New JerseyAges 18 years+ - NCT04028219Recruiting
Study for people transitioning gender-affirming care
This study looks at people who are preparing to start gender-affirming hormone treatment. It may help researchers understand what support is needed before hormones begin.
Frankfurt am Main, HesseAges 18 years+ - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT05391217Recruiting
Remote activity and symptom surveys for transgender cancer survivors
This study tests whether it’s practical to track daily activity with a Fitbit and collect symptom/quality-of-life answers (surveys and possibly interviews) by phone or computer. It may help improve how care teams monitor well-being for transgender people who have had cancer or are at risk.
Los Angeles, CaliforniaAges 18 years+ - NCT05883553Recruiting
Erection device vs cover after gender-affirming penis surgery
This trial compares two options to help people who have had phalloplasty have penetrative sex: an erection prosthesis (an implanted device) versus an epithesis (a removable cover/prosthetic). It aims to see which option works better and is acceptable for restoring sensation, function, and sexual penetration.
Ghent, East-FlandersAges 18 years+ - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06247267Recruiting
Hormone replacement therapy in military members
This study is looking at how sex hormone replacement therapy affects active-duty military members and their families. It aims to understand the effects in people with low testosterone or those receiving gender-affirming hormones.
Bethesda, MarylandAges 18–65 - NCT06409975Recruiting
Self-compassion program for transgender and nonbinary young adults
This study tests an online self-compassion program designed for transgender and nonbinary young adults ages 18–29. It aims to see if the program is easy to use and helpful for reducing stress and improving emotional well-being.
Providence, Rhode IslandAges 18–29 - NCT06530992Recruiting
Tucking and semen quality in adult trans women
This study looks at whether tucking affects semen quality in adult transgender women who are about to start or are on hormone therapy. The results could help patients understand how tucking might impact their fertility options.
InnsbruckAges 18–50 - NCT06639763Recruiting
Erectile aid use after gender-affirming surgery
This study looks at how transgender men and their partners use erectile aids after phalloplasty or metoidioplasty. It hopes to improve sexual health and satisfaction after surgery.
Ghent, East-FlandersAges 18 years+ - NCT06639776Recruiting
Sexual function after erectile implant in transgender people
This study looks at how well erection prostheses (implants that help with erections) work for transgender people after phalloplasty surgery. It aims to understand sexual functioning for both you and your partner.
Ghent, East-FlandersAges 18 years+ - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT06959992Recruiting
Resilience in transgender and nonbinary people in the metaverse
This study explores how transgender and nonbinary people handle social challenges and build resilience in virtual worlds (the metaverse). It aims to understand the impact of online experiences and may help develop better support programs.
Bucharest, BucharestAges 18–35 - NCT06969326RecruitingPhase 3
Estrogen cream after hysterectomy for transgender men
This study tests whether using a topical estrogen cream after hysterectomy surgery can help transgender men have a better recovery. Participants will be randomly assigned to use the cream or not, and researchers will follow up by text message.
Providence, Rhode IslandAges 18 years+ - NCT07131267Recruiting
Study on sexual health in trans men during transition
This study aims to understand how sexual function changes for trans men as they go through the gender affirmation process. The results could help doctors provide better support for your sexual health during your transition.
Eskişehir, TürkiyeAges 18–65 - NCT07187947Recruiting
Heart health in transgender people on hormone therapy
This study looks at how gender-affirming hormone therapy affects the heart and blood vessels in transgender people. If you've been on hormones for at least a year, researchers want to check your cardiovascular health to better understand long-term risks and benefits.
Bologna, BOAges 18 years+ - NCT07252687Recruiting
How Gender-Affirming Care Affects Breast Perception in Trans Men
This study looks at how gender-affirming treatments (like hormone therapy or chest surgery) affect how trans men feel about their chest. It aims to help understand the best timing for these treatments.
InnsbruckAges 16 years+ - NCT07466069Recruiting
Healthy lifestyle program for transgender teens
This trial tests a lifestyle program designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents. It aims to support healthy habits and well-being during a critical developmental stage.
São Paulo, São PauloAges 10–14 - NCT07509853Recruiting
Pleasure-Focused Harm Reduction for Chemsex and Substance Use
This study explores how adding conversation about sexual pleasure to harm reduction services can help men who have sex with men and transgender persons who use drugs during sex or use other substances. If you join, you may learn new ways to reduce risks while still enjoying your sex life.
Pathum Wan, BangkokAges 18 years+ - NCT07624747Recruiting
Brain Health Study for Transgender Adults Starting Hormone Therapy
This study looks at how gender-affirming hormone therapy affects brain health and function in transgender adults. Researchers want to understand the effects of these hormones on the brain before and after treatment begins.
Madison, WisconsinAges 18–45 - NCT06565663Enrolling by invitation
Decision aid for gender-affirming surgeries
This study tests an online decision tool for people considering metoidioplasty or phalloplasty. The tool helps patients compare surgical options to make informed choices.
Hanover, New HampshireAges 18 years+
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Common questions
- Are there clinical trials for transgender?
- Yes. Clin2 currently lists 45 recruiting transgender studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transgender trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transgender trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.