Clinical trials
Transgender clinical trials
Below are recruiting transgender clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07187947Recruiting
Heart health in transgender people on hormone therapy
This study looks at how gender-affirming hormone therapy affects the heart and blood vessels in transgender people. If you've been on hormones for at least a year, researchers want to check your cardiovascular health to better understand long-term risks and benefits.
Bologna, BOAges 18 years+ - NCT07163832Recruiting
Study of transgender teens starting care before 18
This study looks back at the medical records of transgender young people who began gender-affirming care at Strasbourg University Hospital before age 18. It helps doctors understand their experiences and improve future care.
StrasbourgAges 8–17 - NCT07148921Recruiting
Pain perception during gender affirming hormone therapy
This study looks at how starting gender affirming hormone therapy may change your experience of pain. If you are an adult assigned female at birth planning to start testosterone, or an adult assigned male at birth planning to start estradiol, and you have not taken any sex hormones in the past six months, this trial wants to measure your pain perception over time.
Vienna, State of ViennaAges 18 years+ - NCT07131267Recruiting
Study on sexual health in trans men during transition
This study aims to understand how sexual function changes for trans men as they go through the gender affirmation process. The results could help doctors provide better support for your sexual health during your transition.
Eskişehir, TürkiyeAges 18–65 - NCT06969326RecruitingPhase 3
Estrogen cream after hysterectomy for transgender men
This study tests whether using a topical estrogen cream after hysterectomy surgery can help transgender men have a better recovery. Participants will be randomly assigned to use the cream or not, and researchers will follow up by text message.
Providence, Rhode IslandAges 18 years+ - NCT07075731Recruiting
Cervical and endometrial cancer screening before gender-affirming hysterectomy
This study looks at how to best screen for cervical and endometrial (uterine lining) cancer in transgender and gender-diverse people who have had or plan to have a hysterectomy (surgery to remove the uterus and cervix). It aims to make screening more comfortable and effective for this community.
Minneota, MinnesotaAges 18 years+ - NCT06967753RecruitingPhase 4
Switching to a two-drug HIV regimen for transgender women
This trial tests if switching to a two-drug combination of dolutegravir and lamivudine is safe and effective for transgender women who already have undetectable HIV levels on a three-drug regimen. It aims to simplify treatment and reduce side effects.
Buenos Aires, Buenos Aires F.D.Ages 18 years+ - NCT06959992Recruiting
Resilience in transgender and nonbinary people in the metaverse
This study explores how transgender and nonbinary people handle social challenges and build resilience in virtual worlds (the metaverse). It aims to understand the impact of online experiences and may help develop better support programs.
Bucharest, BucharestAges 18–35 - NCT06807580RecruitingPhase 2
Adding progesterone to gender-affirming hormone therapy: a study for transgender women
This study tests whether adding progesterone to your current hormone therapy helps transgender women feel better and more satisfied with their treatment. It might be a good fit if you've been on hormones for at least 6 months and haven't used progesterone before.
Atlanta, GeorgiaAges 18–60 - NCT06093724Recruiting
Imaging pelvic changes after gender-affirming surgery
This study uses MRI scans to see how pelvic structures change after gender-affirming vaginoplasty in transgender women. It may help improve surgical techniques and follow-up care.
Limoges, LimogesAges 18 years+ - NCT06247267Recruiting
Hormone replacement therapy in military members
This study is looking at how sex hormone replacement therapy affects active-duty military members and their families. It aims to understand the effects in people with low testosterone or those receiving gender-affirming hormones.
Bethesda, MarylandAges 18–65 - NCT04254354Recruiting
Body identity clinic for transgender men on testosterone
This trial is for transgender men who want care focused on body identity. It likely studies how testosterone treatment and clinic support affect body-related feelings and wellbeing.
OdenseAges 18 years+ - NCT06670053Recruiting
Testosterone and brain development in teens
This study looks at how starting testosterone therapy affects brain development in transgender and gender-diverse youth. It may help you and your doctor understand the changes to expect.
Aurora, ColoradoAges 12–20 - NCT06565663Enrolling by invitation
Decision aid for gender-affirming surgeries
This study tests an online decision tool for people considering metoidioplasty or phalloplasty. The tool helps patients compare surgical options to make informed choices.
Hanover, New HampshireAges 18 years+ - NCT06409975Recruiting
Self-compassion program for transgender and nonbinary young adults
This study tests an online self-compassion program designed for transgender and nonbinary young adults ages 18–29. It aims to see if the program is easy to use and helpful for reducing stress and improving emotional well-being.
Providence, Rhode IslandAges 18–29 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT06083766Recruiting
Hormone Therapy Effects on Metabolism in Transgender Adults
This study looks at how long-term gender-affirming hormone therapy affects your body's metabolism and energy use. Researchers want to understand these changes better to improve care for transgender and gender-diverse people.
Rochester, MinnesotaAges 18–40 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT05587751Recruiting
Testing how gender-affirming care affects lung function
This study checks whether gender-affirming treatments change breathing/lung test results over time. It may help doctors understand any lung-related effects for transgender and gender-diverse people.
Rochester, MinnesotaAges 14 years+ - NCT05334888Recruiting
Study how sex and gut bacteria relate to heart risk
This study follows people over time to understand how sex-related factors and gut bacteria may affect heart and blood-vessel risk. It may help researchers identify who could benefit from earlier prevention, based on personal risk patterns.
BerlinAges 18–50
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Common questions
- Are there clinical trials for transgender?
- Yes. Clin2 currently lists 44 recruiting transgender studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transgender trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transgender trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.