Clinical trials · San Francisco, CA
Treatment Resistant Depression clinical trials in San Francisco
We’re tracking 6 recruiting treatment resistant depression studies with a site in or near San Francisco — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near San Francisco
- NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT04581902Recruiting
Study blood and brain markers in moderate to severe depression
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
San Francisco, CaliforniaAges 18–70 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Oakland, CaliforniaAges 18–75 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Burlingame, CaliforniaAges 18 years+ - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT07369180Enrolling by invitation
TMS for treatment-resistant depression in adults
This study tests a new type of transcranial magnetic stimulation (TMS) for adults whose depression hasn't gotten better with medication. It compares the real treatment to a sham (inactive) version to see how well it works.
Sunnyvale, CaliforniaAges 22–85
Hear when a new Treatment Resistant Depression trial opens near San Francisco, CA
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Treatment Resistant Depression trials in other cities
Where these studies are running near San Francisco
Institutions with a site for the recruiting treatment resistant depression studies listed above.
- University of California, San Francisco · 2 studies
- Access Multi Specialty Medical Clinic, Inc
- LGTC Group
- SF-CARE, Inc.
- Site 7156
- Site 7159
- Stanford University
What taking part in a treatment resistant depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting treatment resistant depression studies in California.
Common questions
- Are there treatment resistant depression clinical trials near San Francisco?
- Yes. We're currently tracking 6 recruiting treatment resistant depression studies with a site near San Francisco, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a treatment resistant depression study near San Francisco?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Francisco to take part?
- Not necessarily. These studies have a site near San Francisco, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a treatment resistant depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New treatment resistant depression studies open near San Francisco regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.