Closed-loop brain stimulation for hard-to-treat bipolar depression
Part of Mental health clinical trials.
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 22 and 70 years old.
- You have bipolar II disorder with a current depression episode lasting at least 1 year that hasn't improved with treatment.
- You are stable on a mood stabilizing medication like lithium or valproate, or an atypical antipsychotic, for at least 2 weeks before starting.
- You have not had a manic or hypomanic episode in the last 2 years.
- You have tried or been advised to try electroconvulsive therapy (ECT) without lasting success.
- You are willing and able to undergo brain surgery for device implantation and attend multiple study visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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