Treatment
Psilocybin clinical trials
We’re tracking 104 recruiting studies that include Psilocybin, each written for real people, not researchers, below.
Recruiting studies
- NCT03289949RecruitingPhase 1
Study brain effects of a serotonin system drug in adults
This Phase 1 study tests how a serotonin-related drug changes brain activity in healthy adults, using brain imaging (MRI) and other measures. Because it involves a drug that may affect the brain, eligibility is designed to keep the results safe and clear.
CopenhagenAges 18 years+ - NCT07386730RecruitingPhase 1
Psychedelic therapy study for older adults with low well-being
This study tests if a single dose of psilocybin (a psychedelic) or dextromethorphan (a cough suppressant) can improve well-being in healthy older adults who feel their well-being is below average. It aims to understand how these drugs might help boost mood and life satisfaction.
San Francisco, CaliforniaAges 50–85 - NCT07053917RecruitingPhase 1
Psilocybin therapy for stroke recovery
This trial tests whether a medicine called psilocybin (a psychedelic compound) can help people who had a stroke more than a year ago. It aims to see if the therapy can improve healing and flexibility in the brain.
Baltimore, MarylandAges 18 years+ - NCT06898606RecruitingPhase 1/Phase 2
Psilocybin mushrooms with or without Prozac for stubborn depression
This study tests whether a dose of psilocybin (the active ingredient in magic mushrooms) can help treat depression that hasn't improved with standard antidepressants. Some participants will also take the antidepressant fluoxetine (Prozac) to see if it changes the effects.
Foz do Iguaçu, ParanáAges 25–65 - NCT06815653RecruitingPhase 1
Preparing for psychedelics with meditation or music
This study tests whether a meditation-based music program or a music-only program helps people prepare for a psychedelic experience. It's looking for people who have used psychedelics very little before and have no major health issues.
LondonAges 21–65 - NCT06798636RecruitingEarly Phase 1
Psilocybin and mental imagery for young people who self-harm
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with a mental imagery therapy can help reduce self-harm thoughts and behaviors in people ages 16–25. You would receive the drug in a safe clinic setting and complete several therapy sessions and questionnaires over a few weeks.
LondonAges 16–25 - NCT06772753RecruitingPhase 1
Study of Psychedelic Effects in Healthy Adults
This study tests how certain psychoactive substances affect your mind and body. It is looking for healthy volunteers to take part in supervised sessions to explore the effects of these drugs.
Baltimore, MarylandAges 25–55 - NCT06512220RecruitingPhase 2
Psilocybin for treatment-resistant depression brain imaging study
This study tests whether a psilocybin-based treatment can help people with depression that has not improved after trying several antidepressants. You will receive the study treatment and have brain scans to see how it affects brain connections.
Toronto, OntarioAges 18–65
Common questions
- Are there clinical trials studying Psilocybin?
- Yes. Clin2 currently lists 104 recruiting studies that include Psilocybin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Psilocybin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Psilocybin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Psilocybin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.