Psilocybin mushrooms with or without Prozac for stubborn depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether a dose of psilocybin (the active ingredient in magic mushrooms) can help treat depression that hasn't improved with standard antidepressants. Some participants will also take the antidepressant fluoxetine (Prozac) to see if it changes the effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 25 and 64 years old.
- You have a current diagnosis of major depression that is at least moderate in severity.
- You have tried at least one antidepressant medicine at a full dose for 6 to 12 weeks in this episode, but it didn't work well enough.
- You are willing to stop certain antidepressants or other interacting medicines before the study (with a doctor's guidance).
- You do not have bipolar disorder, psychosis, or a close family history of these conditions.
- You are not at immediate risk of suicide and do not have a substance use disorder (except nicotine or caffeine) in the past 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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