Understanding Hyper-IgE Syndrome: Natural History and Genetics
Part of Blood & lymphatic, Genetic & congenital, Immune system & allergy, Infections, Lungs & breathing clinical trials.
This study follows people with or suspected Hyper-IgE syndrome (a rare immune disorder causing repeated infections and skin problems) to understand how the condition develops, how best to manage it, and which genes are involved. Researchers also welcome healthy relatives of patients to help identify genetic patterns.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been referred to NIH with a diagnosis or suspicion of Hyper-IgE syndrome, or another immune condition with similar features
- You are at least 1 month old (if you have the condition) or at least 2 years old (if you are unaffected)
- You are able to understand the study and willing to sign a consent form (or a parent/guardian can consent for you)
- If you're under 30 or have certain kidney or heart conditions, you may skip the heart imaging portion of the study
- You do not have a serious medical, psychiatric, or social condition that would make participation unsafe or overly burdensome
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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