Study of causes and progression of synuclein-related nerve conditions
Part of Brain & nervous system, Mental health clinical trials.
This study follows people over time to better understand “synucleinopathies,” which are conditions that affect the nervous system as it develops and progresses. You may be asked to return for visits and report symptoms, especially those that happen when you stand up.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult age 18 or older
- Have symptoms when standing—dizziness or feeling lightheaded—that improve when you lie down
- Be referred to one of the participating study sites for standing-related intolerance
- Do not have diabetes by standard diabetes diagnosis criteria
- Do not have serious heart failure (congestive heart failure) or lupus/other connective-tissue diseases
- Be able and willing to follow the study plan and return for follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses an accelerometer (a wearable motion sensor) to measure symptoms and blood pressure changes when you stand up. It may help doctors better track how neurogenic orthostatic hypotension affects you and how well current treatments are working.
This early (Phase 1) study tests whether midodrine and droxidopa can improve blood-flow pooling in the belly in people with nerve problems that affect blood pressure when standing. It’s looking at safety and how the body responds, which may help reduce dizziness or fainting for some participants.
This study tests a spinal cord stimulator, a small device placed near the spine, to see if it can help people with conditions like Parkinson's disease or multiple system atrophy who feel very dizzy or faint when standing up. The goal is to reduce these symptoms and improve daily life.
This study looks for early signs of Parkinson's disease in people who have nerve damage in their hands and feet (polyneuropathy) with no known cause, along with drops in blood pressure when standing up. It aims to understand if these early symptoms might predict future Parkinson's.
This study looks at how blood pressure is controlled in people with Parkinson's disease, especially those who feel dizzy when standing up. It may help doctors understand and treat this problem better.
This study tracks changes in people with Parkinson's disease, other movement disorders, or cognitive decline to find better ways to measure disease progression.
Hear when a new Neurogenic Orthostatic Hypotension trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.