Ketamine treatment for depression that hasn’t responded to care
Treatments studied
Part of Mental health clinical trials.
This Phase 2 study tests ketamine for people with major depression that hasn’t improved after at least one antidepressant. It aims to see whether ketamine can reduce depression symptoms during a current depressive episode.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 18 and 55 years old.
- You can understand the study well enough to consent and score at least 90% on a consent quiz.
- You have major depression without psychosis, and your current depressive episode has lasted at least 2 weeks.
- You’ve tried at least one standard antidepressant in the past but it didn’t work.
- Your depression severity is high enough (MADRS score 20 or higher) before the ketamine infusion and on infusion day.
- You should not have certain conditions like bipolar disorder with psychosis, schizophrenia, or an active substance use problem (other than caffeine/nicotine).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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