How ketamine affects energy in cells for treatment-resistant depression
Treatments studied
Part of Mental health clinical trials.
This study looks at how ketamine, a fast-acting treatment for severe depression, affects the energy-producing parts of cells (mitochondria). If you qualify, you'll help researchers understand why ketamine works, which could lead to better depression treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 65 years old.
- You must have a diagnosis of major depressive disorder (severe depression) that has not improved with at least two different antidepressant medications.
- Your depression must be severe, scoring 23 or higher on a standardized depression rating scale called HAM-D.
- You must be medically stable, meaning you do not have any active serious health conditions like cancer, heart disease, or unstable high blood pressure, and your other medications have been stable for at least a month.
- You cannot be pregnant or breastfeeding.
- You cannot have a history of drug or alcohol abuse, sensitivity to ketamine, or take certain medications like lithium or corticosteroids.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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