Infliximab for hard-to-treat brain blood vessel aneurysms
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 1/2 trial tests infliximab, a medicine that calms inflammation, for dolichoectactic aneurysms in the vertebral/basilar brain blood vessels that usually cannot be treated with standard surgery or procedures. The goal is to see if it can improve safety and how the aneurysm behaves over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an adult (18 or older) when you start the study drug.
- Your vertebral and/or basilar artery aneurysm can’t be treated with usual surgery or catheter-based procedures.
- You have not taken infliximab’s type of medicines (anti‑TNF/other biologic drugs) in the last 12 months.
- Your blood and organ tests are in safe ranges (not very low white cells or platelets, not severe anemia, and kidney/liver levels not too high).
- You’re willing to be checked for prior or active tuberculosis (TB) and must have treatment documented if you’ve had TB exposure.
- You can have MRI scans as part of the study and follow all study visits and rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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