Larynx transplant for people with permanent loss of voice
Part of Lungs & breathing clinical trials.
This study looks at whether a larynx (voice box) transplant can help people who have permanent loss of laryngeal function. It is a very small early evaluation (only 3 patients) and would require major surgery and medicines that lower the immune system.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re an adult (18–60 years old).
- You have permanent loss of larynx function—often needing a permanent breathing tube—and prior standard treatments have not worked.
- You must be healthy enough for surgery and follow-up care (an anesthetic risk score of less than 3, as judged by the study team).
- You can understand the risks and agree, and you must sign informed consent; the team also checks that your mental health and readiness are stable.
- You must be able to take anti-rejection (immunosuppressing) medicines and meet related safety rules (for example, no current immunosuppressant use unless already at an allowed dose, and cancer history rules must fit).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how different types of voice surgery affect the voice. Researchers will record and analyze voices before and after surgery to understand the results better.
This study tests a new way of doing lung transplant surgery where you stay breathing on your own during the operation instead of using a breathing tube. The goal is to help you recover faster in the hospital after the transplant.
This trial tests a new anesthetic approach for very underweight patients having a lung transplant. The goal is to help you recover better by keeping you breathing on your own during surgery instead of using a breathing tube. If you qualify, it may offer a more gentle recovery.
This trial tests a new approach to treat throat cancer while trying to preserve your larynx (voice box). It combines chemotherapy drugs and an immunotherapy drug before surgery or radiation. The goal is to see if this can help you avoid needing to have your larynx removed.
This study compares two standard treatments for early-stage cancer in the upper part of the voice box (supraglottic larynx) that hasn't spread to neck lymph nodes: radiation therapy versus surgical removal of the neck lymph nodes. The goal is to see which approach better controls the cancer while preserving quality of life.
This study compares two ways to help you breathe during liver transplant surgery: one uses a mask in your throat, the other uses a tube. The goal is to see which method works better and is safer for people like you.
Hear when a new Laryngeal Transplantation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.