Cord blood stem cell treatment for newborn brain injury
Part of Brain & nervous system clinical trials.
This early-phase study tests whether using a baby’s own cord blood stem cells is safe and feasible for newborns with brain injury from lack of oxygen around birth. It may help researchers find new ways to treat hypoxic-ischemic encephalopathy (brain injury due to oxygen deprivation) in addition to standard care like cooling.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby was born at or after 36 weeks of pregnancy (term).
- At birth (or within 60 minutes), the baby had concerning blood gas results showing oxygen/acid stress, OR met specific birth emergency signs plus low Apgar score or ongoing breathing support at 5 minutes.
- Your baby showed signs of brain injury within 12 hours after birth (an exam score of at least 2).
- Your baby is receiving therapeutic hypothermia (treatment using cooling to protect the brain).
- The baby’s mother does not have certain infections (HIV, HTLV-1/2, hepatitis B or C) and has a negative syphilis test.
- No major birth defects, no known chromosome problem, no very low birth weight (under 1800g), and doctors plan further intensive care if needed; parents must give written consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial gives children with brain injuries an infusion of stem cells from their own or a sibling's umbilical cord blood, or from a matched donor. The goal is to see if these cells can help repair brain damage and improve function.
This trial tests whether giving stem cells along with cooling therapy is safe and helpful for babies who had brain injury from lack of oxygen at birth. It may help improve their recovery and development.
This study looks at a blood test that might help check brain injury in newborns who had a lack of oxygen at birth. The test could give doctors more information to help care for your baby.
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
This trial tests giving stem cells through the nose to newborn babies who have brain injury from lack of oxygen or blood flow during birth. The goal is to reduce the risk of developing cerebral palsy.
This Phase 3 trial studies whether erythropoietin (a medicine related to red-blood-cell growth) can improve outcomes for newborns with moderate to severe brain injury after birth. The study focuses on babies born in low- and middle-income countries and aims to reduce harm from this early brain condition.
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